신규한 6-인다졸릴아미노-3-니트로피리딘 유도체 화합물, 그의 제조방법 및 이를 포함하는 약제학적 조성물
    4.
    发明申请
    신규한 6-인다졸릴아미노-3-니트로피리딘 유도체 화합물, 그의 제조방법 및 이를 포함하는 약제학적 조성물 审中-公开
    新戊酰氨基-3-氨基吡啶衍生化合物,其制备方法和包括其的药物组合物

    公开(公告)号:WO2010067990A2

    公开(公告)日:2010-06-17

    申请号:PCT/KR2009/007219

    申请日:2009-12-04

    CPC classification number: C07D213/76 C07D401/12 C07D401/14

    Abstract: 본 발명은 신규한 6-인다졸릴아미노-3-니트로피리딘 유도체 화합물, 그의 제 조방법, 이를 포함하는 약제학적 조성물, 골다공증 예방 및 치료용 약제를 제조하 기 위한 이의 용도, 이를 이용한 골다공증 예방 및 치료방법을 제공한다. 본 발명 의 6-인다졸릴아미노-3-니트로피리딘 유도체 화합물은 조골세포의 활성을 증가시킬 뿐 아니라 동시에 파골세포 형성을 효과적으로 억제하므로, 골다공증의 예방 및 치 료에 유용하게 사용될 수 있다.

    Abstract translation: 本发明涉及一种新的6-吲唑基氨基-3-硝基吡啶衍生物化合物,其制备方法,含有该衍生物的药物组合物,其用于制备预防和治疗骨质疏松症的药物的应用,以及骨质疏松症的方法 预防和治疗使用相同。 本发明的6-吲唑基氨基-3-硝基吡啶衍生物化合物有效地增加了成骨细胞活性,而且抑制了破骨细胞的形成,因此可有效地用于预防和治疗骨质疏松症。

    4-(1H-인다졸-6-일아미노)-N-아이소프로필-2-(메틸티오)피리미딘-5-카르복스아미드 화합물 또는 이의 약학적으로 허용가능한 염을 포함하는 당뇨병 예방 또는 치료용 조성물
    9.
    发明公开
    4-(1H-인다졸-6-일아미노)-N-아이소프로필-2-(메틸티오)피리미딘-5-카르복스아미드 화합물 또는 이의 약학적으로 허용가능한 염을 포함하는 당뇨병 예방 또는 치료용 조성물 有权
    含有4-1H-吲唑-6-基氨基-N-异丙基-2-甲硫基嘧啶-5-甲酰胺或其药学上可接受的盐的糖尿病预防或治疗组合物

    公开(公告)号:KR1020120133633A

    公开(公告)日:2012-12-11

    申请号:KR1020110052370

    申请日:2011-05-31

    CPC classification number: A61K31/506 A23L33/10 A61K31/416 Y10S514/866

    Abstract: PURPOSE: A pharmaceutical composition containing 4-(1H-indazole-6-ylamino)-N-isopropyl-2-(methylthio)pyrimidine-5-carboxamide compounds is provided to suppress beta cell apoptosis and to control blood glucose. CONSTITUTION: A pharmaceutical composition for preventing or treating diabetes contains 4-(1H-indazole-6-ylamino)-N-isopropyl-2-(methylthio)pyrimidine-5-carboxamide compounds of chemical formula 1 or pharmaceutically acceptable salts thereof. A health functional food for preventing or treating diabetes contains the compound of chemical formula 1 or salts. A method for preparing the compound of chemical formula 1 comprises: a step of reacting 6-aminoindazole with 4-chloro-2-methylthio-5-pyrimidine carboxylic acid ethyl ester under the presence of a base to prepare 4-(1H-indazole-6-ylamino)-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester; a step of hydrating the 4-(1H-indazole-6-ylamino)-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester to prepare 4-(1H-indazole-6-ylamino)-2-(methylthio)pyrimidine-5-carboxylic acid; and a step of reacting isopropyl amine with 4-(1H-indazole-6-ylamino)-2-(methylthio)pyrimidine-5-carboxylic acid.

    Abstract translation: 目的:提供含有4-(1H-吲唑-6-基氨基)-N-异丙基-2-(甲硫基)嘧啶-5-甲酰胺化合物的药物组合物,以抑制β细胞凋亡并控制血糖。 构成:用于预防或治疗糖尿病的药物组合物含有化学式1的4-(1H-吲唑-6-基氨基)-N-异丙基-2-(甲硫基)嘧啶-5-甲酰胺化合物或其药学上可接受的盐。 用于预防或治疗糖尿病的健康功能食品含有化学式1或其盐的化合物。 制备化学式1的化合物的方法包括:在碱的存在下使6-氨基吲唑与4-氯-2-甲硫基-5-嘧啶羧酸乙酯反应,制备4-(1H-吲唑-2-基) 吡啶-6-基氨基)-2-(甲硫基)嘧啶-5-甲酸乙酯; 水化4-(1H-吲唑-6-基氨基)-2-(甲硫基)嘧啶-5-甲酸乙酯以制备4-(1H-吲唑-6-基氨基)-2-(甲硫基)嘧啶 -5-羧酸 和异丙胺与4-(1H-吲唑-6-基氨基)-2-(甲硫基)嘧啶-5-甲酸反应的步骤。

    신규한 2, 6-위치가 치환된 3-니트로피리딘 유도체 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물
    10.
    发明公开
    신규한 2, 6-위치가 치환된 3-니트로피리딘 유도체 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물 无效
    新的2,6-取代的3-硝基吡啶衍生物,其制备方法和包含其的药物组合物

    公开(公告)号:KR1020100066868A

    公开(公告)日:2010-06-18

    申请号:KR1020080125361

    申请日:2008-12-10

    CPC classification number: C07D213/74

    Abstract: PURPOSE: A 3-nitropyridine derivative compound in which 2,6-site is substituted is provided to suppress osteoclast formation and to prevent and treat osteoporosis. CONSTITUTION: A 3-nitropyridine derivative compound in which 2,6-site is substituted is denoted by chemical formula 1. A method for preparing the 3-nitropyridine derivative comprises: and a step of reacting 2,6dichloro-3-nitropyridine and 5-amino triazole under the presence of base to obtain 2-(1H-benzotriazole-5-yl)amino-6-chloro-3-nitropyridine with HNR_2(CH_2)nR1 amine compound to obtain 3-nitropyridine derivative in which 1,6 site of chemical formula 1. A pharmaceutical composition for preventing or treating osteoporosis contains 3-nitropyridine derivative compound or pharmaceutically acceptable salt as an active ingredient.

    Abstract translation: 目的:提供2,6-取代的3-硝基吡啶衍生物,以抑制破骨细胞形成和预防和治疗骨质疏松症。 构成:其中2,6-位被取代的3-硝基吡啶衍生物化合物由化学式1表示。制备3-硝基吡啶衍生物的方法包括:使2,6-二氯-3-硝基吡啶与5- 氨基三唑在碱存在下反应,得到2-(1H-苯并三唑-5-基)氨基-6-氯-3-硝基吡啶与HNR 2(CH 2)n R 1胺化合物,得到3-硝基吡啶衍生物,其中, 化学式1.用于预防或治疗骨质疏松症的药物组合物含有3-硝基吡啶衍生物化合物或药学上可接受的盐作为活性成分。

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