公开(公告)号：US20070207121A1

公开(公告)日：2007-09-06

申请号：US10576140

申请日：2004-04-28

Applicant: Jerome Zeldis

Inventor： Jerome Zeldis

IPC: A61K39/395 ,  A61K38/21 ,  A61K31/56 ,  A61K31/555 ,  A61K31/522 ,  A61K31/4704 ,  A61K31/425 ,  A61K31/4035

CPC classification number: A61K38/185 ,  A61K31/454 ,  A61K31/522 ,  A61K31/545 ,  A61K31/557 ,  A61K31/56 ,  A61K38/21 ,  A61K38/27 ,  G01J3/0208 ,  G01J3/0286 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/501 ,  G01J3/524 ,  Y10S514/912 ,  A61K2300/00

Abstract: Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Abstract translation: 公开了治疗，预防和/或治疗黄斑变性的方法。 具体实施方案包括单独或与第二活性剂和/或手术组合施用选择性细胞因子抑制药物或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

公开(公告)号：US20070153352A1

公开(公告)日：2007-07-05

申请号：US11412914

申请日：2006-04-28

Applicant: Kohei Shibata ,  Nobuhiro Fukushima ,  Tamotsu Akashi ,  Toshiya Kishida ,  Tsuyoshi Yamamoto ,  Hirofumi Aota ,  Shinji Yamashita ,  Shinichi Takeuchi ,  Hiroyuki Furukawa ,  Yoshinobu Kubota

Inventor： Kohei Shibata ,  Nobuhiro Fukushima ,  Tamotsu Akashi ,  Toshiya Kishida ,  Tsuyoshi Yamamoto ,  Hirofumi Aota ,  Shinji Yamashita ,  Shinichi Takeuchi ,  Hiroyuki Furukawa ,  Yoshinobu Kubota

IPC: G02B26/00 ,  H04B10/12 ,  G02F1/00 ,  H01S3/00

CPC classification number: G02B6/2706 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/0286 ,  G01J3/0291 ,  G02B6/2766 ,  G02B6/29311 ,  G02B6/29313 ,  G02B6/2938 ,  G02B6/3512 ,  G02B6/3548 ,  G02B6/356 ,  G02B6/3582 ,  G02B6/4215

Abstract: A housing 20 is equipped for supporting, from a side, a platform of a wavelength selection device comprising an input/output port 10, a collimator 11, an expanding optical system 12, a spectroscopic element, a collecting optical system 14 and a micro electro mechanical system (MEMS) mirror array 15. Because the above noted optical member is supported from the side only, influences of a thermal expansion is limited to the height direction of the optical member and the optical axis direction. By these aspects, the influence of thermal expansion is limited to a two-dimensional from a common three-dimensional, thereby enabling a design of a countermeasure to an influence of a thermal expansion. Also, the support from the side does not create a dead space thereby making the wavelength selection device compact.

Abstract translation: 壳体20被配备用于从一侧支撑包括输入/​​输出端口10，准直器11，扩展光学系统12，分光元件，收集光学系统14和微电子的波长选择装置的平台 机械系统（MEMS）镜阵列15.由于上述光学构件仅从侧面被支撑，所以热膨胀的影响限于光学构件的高度方向和光轴方向。 通过这些方面，热膨胀的影响从普通的三维被限制为二维，从而能够设计对热膨胀的影响的对策。 此外，来自侧面的支撑件不会产生死空间，从而使波长选择装置紧凑。

公开(公告)号：US07239782B1

公开(公告)日：2007-07-03

申请号：US10934885

申请日：2004-09-03

Applicant: Patrick J. Treado ,  Matthew P. Nelson ,  Scott A. Keitzer ,  Ryan D. Smith

Inventor： Patrick J. Treado ,  Matthew P. Nelson ,  Scott A. Keitzer ,  Ryan D. Smith

IPC: G02B6/06 ,  G01J3/44 ,  A61B1/06

CPC classification number: G02B6/06 ,  A61B1/00165 ,  A61B1/043 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/07 ,  A61B5/0075 ,  A61B5/0084 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/44 ,  G01J2003/1213

Abstract: A fiberscope device is disclosed which is suitable for video imaging, laser Raman spectroscopy and laser Raman spectroscopic (i.e. chemical) imaging. The fiberscope design minimizes fiber background interference arising from the laser delivery fiber optic and the coherent fiber optic light gathering bundle while maintaining high light throughput efficiency through the use of integrated spectral filters. In the fiberscope design, the laser delivery fiber optic is offset from the coherent fiber optic light gathering bundle. The laser delivery field is captured entirely by the light gathering field of view of the coherent fiber bundle. The fiberscope incorporates spectral filter optical elements that provide environmental insensitivity, particularly to temperature and moisture. The fiberscope is suited to the analysis of a wide range of condensed phase materials (solids and liquids), including the analysis of biological materials such as breast tissue lesions and arterial plaques, in such a manner to delineate abnormal from normal tissues.

Abstract translation: 公开了适用于视频成像，激光拉曼光谱和激光拉曼光谱（即化学）成像的纤维内窥镜装置。 纤维镜设计可以最大限度地减少激光传输光纤和相干光纤采集光束产生的光纤背景干扰，同时通过使用集成光谱滤波器保持高光通量效率。 在纤维镜设计中，激光传输光纤与相干光纤聚光束偏移。 激光输送场完全由相干光纤束的聚光场捕获。 纤维镜包含光谱滤光器光学元件，其提供环境不敏感性，特别是对温度和湿度。 纤维内窥镜适用于分析各种凝聚相材料（固体和液体），包括分析生物材料如乳房组织损伤和动脉斑块，以便从正常组织中描绘异常。

公开(公告)号：US20070045524A1

公开(公告)日：2007-03-01

申请号：US11593015

申请日：2006-11-06

Applicant: Jack Rains ,  Don May ,  David Ramer

Inventor： Jack Rains ,  Don May ,  David Ramer

IPC: G01J1/00

CPC classification number: F21V7/0008 ,  F21K9/62 ,  F21K9/68 ,  F21S2/00 ,  F21S10/02 ,  F21V5/002 ,  F21V5/008 ,  F21V7/22 ,  F21V11/10 ,  F21V14/06 ,  F21V23/0442 ,  F21V23/0457 ,  F21V2200/13 ,  F21W2131/406 ,  F21Y2113/00 ,  F21Y2113/13 ,  F21Y2113/20 ,  F21Y2115/10 ,  G01J1/08 ,  G01J3/02 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0254 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0286 ,  G01J3/10 ,  G01J3/50 ,  G01J3/501 ,  G02B5/0252 ,  G02B5/0278 ,  G02B5/0284 ,  G02B6/0008 ,  G03B15/06 ,  G09F13/0404 ,  G09F13/06 ,  G09F13/14 ,  G09F13/22 ,  H05B33/0803 ,  H05B33/0812 ,  H05B33/0842 ,  H05B33/0863 ,  H05B33/0869 ,  H05B33/0872 ,  H05B35/00 ,  Y02B20/343

Abstract: A light fixture, using one or more solid state light emitting elements utilizes a diffusely reflect chamber to provide a virtual source of uniform output light, at an aperture or at a downstream optical processing element of the system. Systems disclosed herein also include a detector, which detects electromagnetic energy from the area intended to be illuminated by the system, of a wavelength absent from a spectrum of the combined light system output. A system controller is responsive to the signal from the detector. The controller typically may control one or more aspects of operation of the solid state light emitter(s), such as system ON-OFF state or system output intensity or color. Examples are also discussed that use the detection signal for other purposes, e.g. to capture data that may be carried on electromagnetic energy of the wavelength sensed by the detector.

Abstract translation: 使用一个或多个固态发光元件的灯具利用漫反射室来在系统的孔径或下游光学处理元件处提供均匀输出光的虚拟源。 本文公开的系统还包括检测器，其从组合光系统输出的频谱中不存在的波长检测来自系统要被照明的区域的电磁能。 系统控制器响应来自检测器的信号。 控制器通常可以控制固态光发射器的操作的一个或多个方面，诸如系统开 - 关状态或系统输出强度或颜色。 还讨论了将其用于其它目的的检测信号的实例。 以捕获可以由检测器感测的波长的电磁能量承载的数据。

公开(公告)号：US20070023663A1

公开(公告)日：2007-02-01

申请号：US11190688

申请日：2005-07-27

Applicant: Chungte Chen ,  John Anderson

Inventor： Chungte Chen ,  John Anderson

IPC: G01J5/02

CPC classification number: G02B17/0804 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0286 ,  G01J3/36 ,  G01J5/024 ,  G01J5/061 ,  G01J5/08 ,  G01J5/0806 ,  G01J5/0809 ,  G01J5/0862 ,  G01J5/602 ,  G01J2003/1213 ,  G01J2005/0077 ,  G02B5/282 ,  H01L27/14625 ,  H01L27/14649 ,  H01L31/02325

Abstract: A sensor system senses a scene and includes a dual-band imaging infrared detector lying on a beam path, wherein the infrared detector detects infrared images in a first infrared wavelength band and in a second infrared wavelength band; and a two-color cold-shield filter lying on the beam path between the infrared detector and the scene. The cold-shield filter defines a first aperture size for infrared light of the first infrared wavelength band, and a second aperture size larger than the first aperture size for infrared light of the second infrared wavelength band. The first infrared wavelength band has wavelengths less than wavelengths of the second infrared wavelength band.

公开(公告)号：US20060279734A1

公开(公告)日：2006-12-14

申请号：US10760145

申请日：2004-01-16

Applicant: Ming Yan ,  Anthony Ticknor ,  Calvin Ho ,  Hao Xu ,  Jason Weaver ,  Thomas Tarter ,  Jane Lam

Inventor： Ming Yan ,  Anthony Ticknor ,  Calvin Ho ,  Hao Xu ,  Jason Weaver ,  Thomas Tarter ,  Jane Lam

IPC: G01J3/28

CPC classification number: G02B6/12026 ,  G01J3/0286 ,  G02B6/12011

Abstract: A linearized thermal and optical model of an optical integrated circuit can be used to temperature-stabilize one or more optical elements of the circuit using active temperature regulation. To stabilize a single optical element, such as an arrayed waveguide grating (AWG), a temperature sensor and a heater can be provided proximate to the grating. Thermal and optical coefficients can be then used to select an appropriate temperature set-point for the temperature controller that receives readings from the sensor and determines the power dissipated in the heater. Multiple AWG's can be stabilized individually, using the same process and lumping cross-heating factors together with other environmental factors. Alternatively, multiple AWG's can be stabilized using fewer sensors than AWG's, by stabilizing one of the AWG's in the same manner as in the case of a single AWG, and determining power dissipated in the heaters of the remaining AWG's based on the linearized model.

Abstract translation: 可以使用光学集成电路的线性化热和光学模型来使用主动温度调节来温度稳定电路的一个或多个光学元件。 为了稳定单个光学元件，例如阵列波导光栅（AWG），可以在光栅附近提供温度传感器和加热器。 然后可以使用热系数和光学系数为温度控制器选择适当的温度设定点，该温度控制器从传感器接收读数并确定加热器中消耗的功率。 多个AWG可以单独稳定，使用相同的过程并将交叉加热因子与其他环境因素结合在一起。 或者，通过使用比AWG更少的传感器，可以使用比AWG更少的传感器来稳定多个AWG，通过以与单个AWG相同的方式稳定AWG之一，并根据线性化模型确定剩余AWG的加热器中消耗的功率。

公开(公告)号：US07145657B2

公开(公告)日：2006-12-05

申请号：US11370670

申请日：2006-03-08

Applicant: Steven H. Peterson ,  Robert A. Lamfers

Inventor： Steven H. Peterson ,  Robert A. Lamfers

IPC: G01J3/50

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0286 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/50 ,  G01J3/501 ,  G01J3/524

Abstract: An LED-based color measurement instrument including an illumination system and a sensing system. The illumination system includes modulated LEDs and a temperature control system for regulating the temperature of the LEDs, thereby improving the consistency of their performance. The sensing system includes a photodiode, a transimpedance amplifier, and an integrator in the first stage to cancel the effect of ambient light on the output of the first stage. The sensing system also includes a lens system for imaging a target area of the target sample onto the photo sensor in a manner so that the product of the target area times the solid angle captured by the lens system is generally uniform over a selected range of distances, thereby reducing the positional sensitivity of the instrument with respect to the target sample.

公开(公告)号：US20060268948A1

公开(公告)日：2006-11-30

申请号：US11402484

申请日：2006-04-11

Applicant: Randy May

Inventor： Randy May

IPC: H01S3/10

CPC classification number: G01J3/02 ,  G01J3/0286 ,  G01J3/26 ,  G01J3/28 ,  G01J9/00 ,  H01S3/1303 ,  H01S5/0014 ,  H01S5/0617 ,  H01S5/0687 ,  H01S5/4087

Abstract: The method and system operate to maintain a widely tunable laser (WTL) at a selected transmission wavelength. To lock the WTL to an ITU grid line, a portion of the output beam from the WTL is routed through the etalon to split the beam into a transmission line for detection by an etalon fringe detector. Another portion of the beam is routed directly to a laser wavelength detector to determine the power of the beam. A wavelength-locking controller compares signals from the two detectors and adjusts the temperature of the etalon to align the wavelength of one of the transmission lines of the etalon with the wavelength of the output beam, then controls the WTL in a feedback loop to lock the laser to the etalon line. The wavelength-locking controller thereafter monitors the temperature of the etalon and keeps the temperature constant to prevent any wavelength drift attributable to the etalon.

公开(公告)号：US07139072B1

公开(公告)日：2006-11-21

申请号：US10845415

申请日：2004-05-11

Applicant: Pamela A. Boss ,  Gregory W. Anderson ,  Stephen H. Lieberman

Inventor： Pamela A. Boss ,  Gregory W. Anderson ,  Stephen H. Lieberman

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0286 ,  G01N21/658

Abstract: A thermoelectrically cooled surface-enhanced Raman Spectroscopy (TEC-SERS) fiber optic probe for real-time and in-situ monitoring of volatile organic compounds in gas, liquid, and soil environments. The TEC-SERS probe comprises a sample chamber for receiving a gas sample and a fiber optic Raman probe. The sample chamber comprises an inlet having a semipermeable membrane for separating moisture from the gas sample, a SERS substrate mounted on a thermoelectric cooler, a mass flow device for providing airflow, and an output port. The fiber optic Raman probe is operably coupled to a transparent window in the sample chamber for directing an optical excitation signal to irradiate the SERS substrate and for receiving a SERS optical signal from analytes from the gas sample that are in contact with the SERS substrate.

Abstract translation: 一种用于实时和原位监测气体，液体和土壤环境中挥发性有机化合物的热电冷却表面增强拉曼光谱（TEC-SERS）光纤探针。 TEC-SERS探针包括用于接收气体样品和光纤拉曼探针的样品室。 样品室包括具有用于从气体样品分离水分的半透膜的入口，安装在热电冷却器上的SERS衬底，用于提供气流的质量流量装置和输出端口。 光纤拉曼探针可操作地耦合到样品室中的透明窗口，用于引导光激发信号照射SERS衬底，并用于从与SERS衬底接触的气体样品的分析物接收SERS光信号。

公开(公告)号：US20060192958A1

公开(公告)日：2006-08-31

申请号：US11412802

申请日：2006-04-27

Applicant: Dale Harrison

Inventor： Dale Harrison

IPC: G01J1/42 ,  G01J3/28

CPC classification number: G01J3/2803 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/027 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/08 ,  G01J3/10 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/42 ,  G01J3/4531 ,  G01N21/211 ,  G01N21/274 ,  G01N21/33 ,  G01N21/47 ,  G01N21/55 ,  G01N21/9501 ,  G01N2021/335

Abstract: A spectroscopy system is provided which is optimized for operation in the VUV region and capable of performing well in the DUV-NIR region. Additionally, the system incorporates an optical module which presents selectable sources and detectors optimized for use in the VUV and DUV-NIR. As well, the optical module provides common delivery and collection optics to enable measurements in both spectral regions to be collected using similar spot properties. The module also provides a means of quickly referencing measured data so as to ensure that highly repeatable results are achieved. The module further provides a controlled environment between the VUV source, sample chamber and VUV detector which acts to limit in a repeatable manner the absorption of VUV photons. The use of broad band data sets which encompass VUV wavelengths, in addition to the DUV-NIR wavelengths enables a greater variety of materials to be meaningfully characterized. Array based detection instrumentation may be exploited to permit the simultaneous collection of larger wavelength regions.

Abstract translation: 提供了一种光谱系统，其被优化用于在VUV区域中的操作并且能够在DUV-NIR区域中表现良好。 此外，该系统还包含一个光学模块，该模块提供可用于VUV和DUV-NIR中优化的可选择的源和检测器。 同样，光学模块提供通用的传送和收集光学器件，以使得能够使用类似的光点特性来收集两个光谱区域中的测量。 该模块还提供了快速参考测量数据的方法，以确保实现高度可重复的结果。 该模块还在VUV源，样品室和VUV检测器之间提供受控的环境，其作用是以可重复的方式限制VUV光子的吸收。 除了DUV-NIR波长之外，使用包含VUV波长的宽带数据集使得可以有意义地表征更多种类的材料。 可以利用基于阵列的检测仪器来允许同时收集更大的波长区域。