公开(公告)号：US20180003624A1

公开(公告)日：2018-01-04

申请号：US15537052

申请日：2015-12-02

Applicant: Siemens Aktiengesellschaft

Inventor： Franz STEINBACHER

IPC: G01N21/3504 ,  G01N21/39 ,  G01J3/10 ,  G01J3/433

CPC classification number: G01N21/3504 ,  G01J3/108 ,  G01J3/433 ,  G01J3/4338 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/068

Abstract: An absorption spectrometer which measures a gas component concentration in a measured gas and which operates via wavelength modulation spectroscopy, wherein the light wavelength of a wavelength-tunable light source is periodically varied over a gas component absorption line of interest and simultaneously sinusoidally modulated with a high frequency and a low amplitude signal, and wherein the measurement signal of a detector is demodulated in a phase-sensitive manner at the frequency and/or a harmonic of the frequency and further analyzed, where modulation starts in each period or each n-th period with the frequency in a time interval before the beginning of the time function and is performed with a higher amplitude than during the time function to demodulate the measurement signal in a phase-synchronous manner, where a device provided for the phase-sensitive demodulation is synchronized during the time interval such that a cable for transmitting synchronization signals is no longer necessary.

公开(公告)号：US20170343477A1

公开(公告)日：2017-11-30

申请号：US15607457

申请日：2017-05-27

Applicant: Verily Life Sciences LLC

Inventor： Charles Santori ,  Supriyo Sinha ,  Cheng-Hsun Wu ,  James Higbie ,  Seung Ah Lee

IPC: G01N21/64 ,  A61B5/00 ,  G01J3/32 ,  G01J3/44

CPC classification number: G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/18 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/433 ,  G01J3/4406 ,  G01J2003/1243 ,  G01N21/6408 ,  G01N21/6445 ,  G01N21/6458 ,  G01N2021/6471 ,  G01N2201/0675 ,  G02B21/004 ,  G02B21/0076 ,  G02B21/16

Abstract: Systems and methods for hyperspectral imaging are described. In one implementation, a hyperspectral imaging system includes a sample holder configured to hold a sample, an illumination system, and a detection system. The illumination system includes a light source configured to emit excitation light having one or more wavelengths, and a first set of optical elements that include a first spatial light modulator (SLM), at least one lens, and at least one dispersive element. The illumination system is configured to structure the excitation light into a predetermined two-dimensional pattern at a conjugate plane of a focal plane in the sample, spectrally disperse the structured excitation light in a first lateral direction, and illuminate the sample in an excitation pattern with the one or more wavelengths dispersed in the first lateral direction.

公开(公告)号：US20170285030A1

公开(公告)日：2017-10-05

申请号：US15491305

申请日：2017-04-19

Applicant: UNIVERSITY OF CENTRAL LANCASHIRE

Inventor： Matthew James BAKER ,  Peter ABEL ,  Robert William LEA

IPC: G01N33/574

CPC classification number: G01N33/57407 ,  G01J3/433 ,  G01N21/35 ,  G01N21/552 ,  G01N21/63 ,  G01N33/49 ,  G01N33/574 ,  G01N2021/3196 ,  G01N2021/3595 ,  G01N2030/743 ,  G01N2201/129 ,  G01N2800/52 ,  G01N2800/7028

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by assaying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumours in a subject.

公开(公告)号：US09719917B2

公开(公告)日：2017-08-01

申请号：US13130166

申请日：2009-11-23

Applicant: Hakan Frojdh ,  Mikael Hornqvist ,  Stig Tormod ,  Patrik Akerstrom

Inventor： Hakan Frojdh ,  Mikael Hornqvist ,  Stig Tormod ,  Patrik Akerstrom

IPC: G01N21/61 ,  G01N21/33 ,  G01N21/05 ,  G01N21/51 ,  G01J3/02 ,  G01J3/433 ,  G01N21/03

CPC classification number: G01N21/33 ,  G01J3/0218 ,  G01J3/0291 ,  G01J3/42 ,  G01J3/433 ,  G01N21/05 ,  G01N21/51 ,  G01N2021/0346 ,  G01N2201/061 ,  G01N2201/0853 ,  G01N2201/086

Abstract: The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.

公开(公告)号：US09628682B2

公开(公告)日：2017-04-18

申请号：US13548801

申请日：2012-07-13

Applicant: David B. Pollock ,  Patrick J. Reardon

Inventor： David B. Pollock ,  Patrick J. Reardon

IPC: H04N5/225 ,  G01J3/28 ,  G01J3/433 ,  G01J3/447 ,  G01J3/02 ,  G02B26/08 ,  G02B27/00 ,  H04N5/232 ,  H04N5/349

CPC classification number: H04N5/2254 ,  G01J3/0208 ,  G01J3/0262 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/433 ,  G01J3/447 ,  G02B26/0891 ,  G02B27/0018 ,  H04N5/23229 ,  H04N5/349

Abstract: A camera concurrently produces an orthographic map and map spectral content. Illumination from an image passes through a phase modulator and the resulting rotating photo-flux phase is converted to an electrical signal by multiple adjacent sensors of detectors of array of detectors. The amount of unwanted illumination reaching the sensors is reduced by a set of baffles that shield and protect the transducers from unwanted out-of-field light and other light sources.

公开(公告)号：US09612153B2

公开(公告)日：2017-04-04

申请号：US14950617

申请日：2015-11-24

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Yoichi Kawada ,  Takashi Yasuda ,  Hironori Takahashi

IPC: G01J5/02 ,  G01J1/44 ,  G01J4/04 ,  G01J1/42 ,  G01J1/04 ,  G01J3/433 ,  G01J3/42 ,  G01J3/02 ,  G01R15/24 ,  G01R29/08 ,  G01N21/3581

CPC classification number: G01J1/44 ,  G01J1/0429 ,  G01J1/4228 ,  G01J3/0224 ,  G01J3/0262 ,  G01J3/42 ,  G01J3/433 ,  G01J3/4338 ,  G01J4/04 ,  G01J2001/4242 ,  G01N21/3581 ,  G01R15/241 ,  G01R29/0871

Abstract: In this electric field vector detection method, an electro-optic crystal, where a (111) surface of an optical isotropic medium is cut out, is used as a terahertz wave detection element. The method includes: causing polarization of probe light of ultrashort pulsed light to be circular polarization; allowing the probe light having circular polarization to enter the terahertz wave detection element and probing the terahertz wave; modulating the probe light, having probed the terahertz wave, by a rotating analyzer and detecting the modulated probe light by a photodetector; performing lock-in detection of a detection signal from the photodetector by a lock-in detector using a frequency based on a rotational frequency of the rotating analyzer as a reference signal; and detecting an electric field vector of the terahertz wave based on a detection signal from the lock-in detector.

公开(公告)号：US20170059403A1

公开(公告)日：2017-03-02

申请号：US15251952

申请日：2016-08-30

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Ulf FROEHLICH ,  Eric WAPELHORST

IPC: G01J3/02 ,  H01S5/0683 ,  G01J1/42 ,  H01S5/068 ,  G01J3/42 ,  G01J3/26

CPC classification number: G01J3/027 ,  G01J1/4257 ,  G01J3/26 ,  G01J3/42 ,  G01J3/433 ,  G01J2003/4334 ,  G01N21/00 ,  G01N21/39 ,  G01N2021/399 ,  H01S5/005 ,  H01S5/0092 ,  H01S5/0612 ,  H01S5/0617 ,  H01S5/0622 ,  H01S5/06804 ,  H01S5/06808 ,  H01S5/0683 ,  H01S5/12 ,  H01S5/4087

Abstract: An operating value of a first laser parameter of a laser device in a laser absorption spectrometer is optimized. The wavelength of laser device emitted light is adjusted by the first or a second laser parameter. The laser absorption spectrometer comprises a light intensity detector measuring the laser light intensity from the laser device. For each of multiple values of the first laser parameter: the light intensity detector measures light intensity obtained across a range of second laser parameter values, and an extremum in the light intensity measure and a peak position for the extremum are identified. A range of first laser parameter values is identified within the values of the first laser parameter for which there is a continuous trend in changes to the identified peak position with changes to the first laser parameter. The first laser parameter operating value is set to be within the identified range.

Abstract translation: 激光吸收光谱仪中的激光装置的第一激光参数的操作值被优化。 通过第一或第二激光参数调节激光器发射光的波长。 激光吸收光谱仪包括测量来自激光装置的激光强度的光强度检测器。 对于第一激光参数的多个值中的每一个：光强度检测器测量在第二激光参数值的范围内获得的光强度，并且识别光强测量中的极值和极值的峰值位置。 在第一激光参数的值内识别出一系列第一激光参数值，在第一激光参数的值中，随着对第一激光参数的改变，对所识别的峰位置的变化存在连续趋势。 第一激光参数工作值设定在识别范围内。

公开(公告)号：US20160377530A1

公开(公告)日：2016-12-29

申请号：US15192904

申请日：2016-06-24

Applicant: Fresenius Medical Care Holdings, Inc.

Inventor： Louis L. Barrett

IPC: G01N21/27 ,  G01N33/49 ,  H04B10/66

CPC classification number: G01N33/49 ,  A61B5/0059 ,  A61B5/0084 ,  A61B5/0261 ,  A61B5/14542 ,  A61B5/14551 ,  A61M1/14 ,  A61M1/3627 ,  A61M2205/3313 ,  A61M2230/20 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/207 ,  G01J3/433 ,  G01N21/31 ,  G01N2021/3181 ,  G01N2201/0627 ,  G01N2201/0691 ,  G01N2201/12

Abstract: An embodiment of the disclosure provides a system for determining information on one or more constituents in a medium. The system includes N light emitters L1 . . . LN, wherein each light emitter Lr provides an amplitude modulated (AM) light at modulation frequency fr into a flow path of the medium from one side of a containment vessel for the medium. The system further includes a photodetector, for receiving the AM light from each light emitter after it passes through the flow path of the medium, and converting the AM light to an electrical signal characterized by a summation of frequency components from each modulation frequency fr. The system further includes one or more measuring circuits providing information about a concentration of one or more constituents in the medium determined from log ratios of a pair of amplitudes of fy and fz frequency components in the electrical signal.

Abstract translation: 本公开的实施例提供了一种用于确定介质中的一个或多个成分的信息的系统。 该系统包括N个发光体L1。 。 。 LN，其中每个光发射器Lr以调制频率fr的调幅（AM）光提供到介质从用于介质的容纳容器的一侧的流动路径。 该系统还包括光电检测器，用于在通过介质的流路之后接收来自每个光发射器的AM光，并将AM光转换成以每个调制频率fr的频率分量的总和为特征的电信号。 该系统还包括一个或多个测量电路，其提供关于介质中的一个或多个成分的浓度的信息，其由电信号中的一对fy和fz频率分量的对数比的对数比确定。

公开(公告)号：US09523636B2

公开(公告)日：2016-12-20

申请号：US14441484

申请日：2012-12-28

Applicant: Halliburton Energy Services, Inc.

Inventor： Michael Pelletier ,  William Soltmann ,  David L. Perkins ,  Christopher M. Jones

IPC: G01N21/31 ,  G01V8/10 ,  H03K7/08 ,  G01N21/47 ,  G01N21/25 ,  G01J3/433 ,  G01J3/10 ,  G01J5/52 ,  H05B37/02 ,  E21B49/08 ,  G01J3/02 ,  G01J3/427 ,  E21B47/10

CPC classification number: G01N21/255 ,  E21B47/102 ,  E21B49/08 ,  G01J3/0205 ,  G01J3/027 ,  G01J3/10 ,  G01J3/108 ,  G01J3/427 ,  G01J3/433 ,  G01J5/522 ,  G01N21/31 ,  G01N21/47 ,  G01N2201/061 ,  G01N2201/06186 ,  G01N2201/0696 ,  G01N2201/12 ,  G01V8/10 ,  H03K7/08 ,  H05B37/0209

Abstract: A light source and a method for its use in an optical sensor are provided, the light source including a resistively heated element. The light source includes a power circuit configured to provide a pulse width modulated voltage to the resistively heated element, the pulse width modulated voltage including: a duty cycle with a first voltage; and a pulse period including a period with a second voltage, wherein: the duty cycle, the first voltage, and the pulse period are selected so that the resistively heated element is heated to a first temperature; and the first temperature is selected to emit black body radiation in a continuum spectral range. Also provided is an optical sensor for determining a chemical composition including a light source as above.

公开(公告)号：US20160334331A1

公开(公告)日：2016-11-17

申请号：US15111824

申请日：2015-01-14

Applicant: OY SPARKLIKE AB

Inventor： Kai Niiranen ,  Miikkael Niemi ,  Mikko Syrjälahti

IPC: G01N21/39 ,  G01J3/433

CPC classification number: G01N21/39 ,  G01J3/433 ,  G01J3/4338 ,  G01N21/274 ,  G01N2021/399

Abstract: A device for non-invasively determining existence of a gas component of interest inside a determination space of a glass unit comprises a laser beam emitting unit comprising a laser source for emitting laser beam towards said measuring space and detecting unit comprising a detector for detecting transmission of said emitted laser beams travelled through said space. The device is configured to measure in a calibration mode locations of at least one reference peak of at least same gas component as to the determined inside the determination space. The emitted laser beam is configured to travel through a calibration space having at least the gas component of interest, and the detecting means is configured essentially to detect or image said beam transmitted through said calibration space. The device is also configured to be moved so to receive said determination space between the laser beam emitting unit and detecting unit for a determining purpose of the existence of the interest gas component inside said determination space.

Abstract translation: 用于非侵入性地确定玻璃单元的确定空间内的感兴趣的气体成分的存在的装置包括：激光束发射单元，包括用于朝向所述测量空间发射激光束的激光源;以及检测单元，所述检测单元包括检测器， 所述发射的激光束穿过所述空间。 该装置被配置为在校准模式中测量与确定空间内确定的至少相同气体成分的至少一个参考峰的位置。 发射的激光束被配置成行进通过至少具有感兴趣的气体分量的校准空间，并且检测装置基本上被配置为检测或成像透过所述校准空间的所述光束。 该装置还被配置为移动以便在激光束发射单元和检测单元之间接收所述确定空间，以确定在所述确定空间内存在感兴趣气体成分的确定目的。