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    Apparatus and method for liquid sample introduction
    91.
    发明授权
    Apparatus and method for liquid sample introduction 失效
    液体样品引入装置及方法

    公开(公告)号：US5345079A

    公开(公告)日：1994-09-06

    申请号：US946118

    申请日：1992-09-17

    Applicant: John B. French ,  Bernard Etkin

    Inventor： John B. French ,  Bernard Etkin

    IPC: G01N1/00 ,  G01N1/04 ,  G01N30/72 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

    CPC classification number: H01J49/049 ,  G01N30/7273 ,  H01J49/045 ,  H01J49/0477 ,  G01N1/22 ,  G01N2001/045

    Abstract: A liquid sample to be analyzed is fed to a micro pump. The pump directs the solution, as a stream of uniformly sized and spaced droplets, into a laminarly flowing stream of hot carrier gas. The carrier gas evaporates the solvents (e.g. water) in the droplets to form a stream of dried particles. The particles are vaporized by a plasma, laser or other heat source. The vapour can be ionized and the ions analyzed by a mass spectrometer, or the vapour can be analyzed by optical spectroscopy. The method reduces oxide and other interference effects, increases sample utilization, and reduces waste, signal noise, and memory effects, increasing instrument productivity. Multiple nozzles can be used to change samples or to shoot calibrating droplets, further increasing productivity. Signal detection can be synchronized with droplet firing, or the signal, which is intrinsically modulated at the drop frequency, can be band pass filtered and synchronously detected, to increase the signal to noise ratio. The dried particles can also be directed into a vacuum chamber and deposited in a desired pattern on a surface in the vacuum, thus delivering controlled microdosages of material onto the surface.

    Abstract translation: 将要分析的液体样品送入微型泵。 泵将溶液作为均匀尺寸和间隔的液滴流引导成层流流动的热载气。 载气蒸发液滴中的溶剂（例如水）以形成干燥颗粒物流。 颗粒通过等离子体，激光或其他热源蒸发。 蒸气可以离子化，通过质谱仪分析离子，也可以通过光谱分析蒸气。 该方法减少了氧化物和其他干扰效应，提高了样品利用率，并减少了浪费，信号噪声和记忆效应，提高了仪器的生产率。 多个喷嘴可用于更换样品或拍摄校准液滴，进一步提高生产率。 信号检测可以与液滴点火同步，也可以在降频时进行本质调制的信号进行带通滤波和同步检测，以提高信噪比。 干燥的颗粒也可以被引导到真空室中并且以真空中的表面以期望的图案沉积，从而将受控的材料微粒剂递送到表面上。

    Method and apparatus for multi-stage particle separation with gas addition for a mass spectrometer
    92.
    发明授权
    Method and apparatus for multi-stage particle separation with gas addition for a mass spectrometer 失效
    使用气相色谱仪进行多级粒子分离的方法和装置

    公开(公告)号：US5162650A

    公开(公告)日：1992-11-10

    申请号：US645649

    申请日：1991-01-25

    Applicant: Mark E. Bier

    Inventor： Mark E. Bier

    IPC: G01N30/72 ,  H01J49/04 ,  H01J49/42

    CPC classification number: H01J49/067 ,  G01N30/7273 ,  G01N30/7293 ,  H01J49/044 ,  H01J49/045 ,  G01N30/724

    Abstract: Disclosed is a multi-stage particle separator for separating analyte from non-analyte solvent in a fluid sample having nebulizing means to form droplets from the liquid sample and means coupled to the nebulizing means for adding helium to the nebulizing means. Furthermore, the multi-stage particle separator has a desolvation chamber for receiving the droplets, the desolvation chamber terminating in a nozzle, a multi-stage momentum separator including skimmers, and means for introducing a gas into one or more of the states to increase pressure of the latter stage so that the particles leave the multi-stage separator substantially free of solvent.

    Abstract translation: 公开了一种多级颗粒分离器，用于在具有雾化装置的流体样品中从非分析物溶剂中分离分析物，以从液体样品形成液滴，并且耦合到雾化装置的装置，用于将氦添加到雾化装置。 此外，多级粒子分离器具有用于接收液滴的去溶剂化室，终止在喷嘴中的去溶剂化室，包含脱水器的多级动量分离器，以及用于将气体引入一种或多种状态以增加压力的装置 使得颗粒离开多级分离器基本上不含溶剂。

    Liquid sample introduction system and method, for analytical plasma spectrometer
    94.
    发明授权
    Liquid sample introduction system and method, for analytical plasma spectrometer 有权

    公开(公告)号：US12068145B2

    公开(公告)日：2024-08-20

    申请号：US17225871

    申请日：2021-04-08

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Ayrat Murtazin

    IPC: H01J49/04 ,  G01J3/02 ,  G01J3/443

    CPC classification number: H01J49/045 ,  G01J3/0267 ,  G01J3/443 ,  H01J49/0409 ,  H01J49/0454

    Abstract: A liquid sample introduction system for a plasma spectrometer includes a sample container for holding a liquid sample, a surface acoustic wave (SAW) nebulizer, arranged to receive a liquid sample from the sample container, an electronic controller for supplying electrical power to the SAW nebulizer so as to produce a surface acoustic wave on a surface of the SAW nebulizer, for generating an aerosol from the supplied sample liquid, and an aerosol transport arrangement for receiving the aerosol from the SAW nebulizer and carrying it into a plasma or flame of a spectrometer. The electronic controller is further configured to control the electrical power to the SAW nebulizer so as to permit adjustment of the aerosol parameters, and to control the aerosol transport arrangement so as to permit adjustment of the aerosol delivery into the plasma or flame of the spectrometer.

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