公开(公告)号：US20240019675A1

公开(公告)日：2024-01-18

申请号：US18350947

申请日：2023-07-12

Applicant: Andor Technology Limited

Inventor： Andrew Colm Dennis ,  Richard Simms

IPC: G02B21/00 ,  G01N21/65 ,  G01J3/02 ,  G01J3/44

CPC classification number: G02B21/0032 ,  G01N21/65 ,  G01J3/0248 ,  G01J3/44 ,  G02B21/0044

Abstract: A Raman spectroscopy apparatus comprises an imaging optical system that transmits light from an object to a spectrograph along an optical path. A scanning device intersects, and is movable with respect to, the optical path. Light is directed onto the scanning device to illuminate the object at a plurality of illumination points. The imaging optical system transmits Raman scattered light emitted from the object at the illumination points to an intermediate image plane, the scanning device being located at the intermediate image plane, and transmits the Raman scattered light from the intermediate image plane to the spectrograph. In comparison with conventional confocal Raman spectroscopy, the apparatus can perform Raman analysis of a sample more quickly, and in comparison with conventional line scan Raman spectroscopy the apparatus can perform Raman analysis more accurately.

公开(公告)号：US11754844B2

公开(公告)日：2023-09-12

申请号：US17896516

申请日：2022-08-26

Applicant: Magic Leap, Inc.

Inventor： Nicole Elizabeth Samec ,  Nastasja U. Robaina ,  Adrian Kaehler ,  Mark Baerenrodt ,  Eric Baerenrodt ,  Christopher M. Harrises ,  Tammy Sherri Powers

IPC: G02B27/01 ,  G01J3/02 ,  G01J3/42 ,  A61B5/1455 ,  A61B5/11 ,  A61B5/00 ,  G06F3/03 ,  G01J3/10 ,  G06F3/01 ,  G01J3/28 ,  G01J3/427 ,  G01N21/359 ,  G01N33/483 ,  F21V8/00 ,  G02B27/00

CPC classification number: G02B27/0172 ,  A61B5/0075 ,  A61B5/1114 ,  A61B5/1121 ,  A61B5/14551 ,  A61B5/6803 ,  A61B5/743 ,  A61B5/744 ,  G01J3/0248 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/10 ,  G01J3/108 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/427 ,  G01N21/359 ,  G01N33/483 ,  G02B6/0076 ,  G02B27/017 ,  G06F3/011 ,  G06F3/013 ,  G06F3/0304 ,  G01J2003/106 ,  G01J2003/2826 ,  G01J2003/425 ,  G02B27/0093 ,  G02B2027/014 ,  G02B2027/0125 ,  G02B2027/0138 ,  G02B2027/0187 ,  G06F3/012

Abstract: In some embodiments, a system comprises a head-mounted frame removably coupleable to the user's head; one or more light sources coupled to the head-mounted frame and configured to emit light with at least two different wavelengths toward a target object in an irradiation field of view of the light sources; one or more electromagnetic radiation detectors coupled to the head-mounted member and configured to receive light reflected after encountering the target object; and a controller operatively coupled to the one or more light sources and detectors and configured to determine and display an output indicating the identity or property of the target object as determined by the light properties measured by the detectors in relation to the light properties emitted by the light sources.

公开(公告)号：US11666221B2

公开(公告)日：2023-06-06

申请号：US16613445

申请日：2018-05-18

Applicant: VANDERBILT UNIVERSITY

Inventor： Christine O'Brien ,  Katherine Cochran ,  Anita Mahadevan-Jansen ,  Kristen Rose Findley ,  William Stokes ,  Lowell Hays ,  Mohsin Tejani ,  Anne-Marie Crowe

IPC: G01J3/44 ,  A61B5/00 ,  G01J3/02 ,  G01J3/28

CPC classification number: A61B5/0075 ,  A61B5/435 ,  A61B5/6875 ,  G01J3/0248 ,  G01J3/2823

Abstract: A method for identification of biochemical markers associated with cervical remodeling over the course of pregnancy of humans includes obtaining Raman signals from the cervix of each of a group of humans with pregnancy at each phase of pregnancy; finding Raman signatures corresponding to each type of cervical tissue from the obtained Raman signals; and identifying biochemical markers associated with cervical remodeling at each phase of pregnancy corresponding to the Raman signatures.

公开(公告)号：US20190003892A1

公开(公告)日：2019-01-03

申请号：US15748611

申请日：2015-08-31

Applicant: Hewlett-Packard Development Company ,L.P.

Inventor： Francesco AIETA ,  Charles M. SANTORI ,  Anita ROGACS

IPC: G01J3/30 ,  G01J3/02 ,  G01J3/44 ,  G01N15/14 ,  G01N21/64 ,  G02B21/16

CPC classification number: G01J3/30 ,  G01J3/0208 ,  G01J3/0248 ,  G01J3/0256 ,  G01J3/2803 ,  G01J3/4406 ,  G01N15/1434 ,  G01N15/147 ,  G01N21/6458 ,  G01N21/658 ,  G01N2015/0053 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2021/6421 ,  G02B21/0008 ,  G02B21/0096 ,  G02B21/16

Abstract: In one implementation, a spectral microscope may comprise a substrate with a planar lens, the planar lens including a phase profile including an axial focus and an oblique focus, a light source to excite a signal of a particle among a plurality of particles, and a detector to receive light generated from the light source from the axial focus of the planar lens and a spectral color component of the excited signal of the particle from the oblique focus of the planar lens.

公开(公告)号：US20180252582A1

公开(公告)日：2018-09-06

申请号：US15846204

申请日：2017-12-19

Applicant: OMRON Corporation

Inventor： Shinya FURUKAWA ,  Takahiro SUGA ,  Hiroaki TAKIMASA

IPC: G01J3/28 ,  G01J3/10

CPC classification number: G01J3/2803 ,  G01B11/026 ,  G01B11/14 ,  G01B11/26 ,  G01J3/0218 ,  G01J3/0237 ,  G01J3/0248 ,  G01J3/0278 ,  G01J3/06 ,  G01J3/10 ,  G02B6/02042 ,  G02B6/32

Abstract: A confocal measuring apparatus (1) includes a light source (10), an optical system (30) configured to receive reflected light from a measurement surface, a light guide part (20) into which a plurality of cores including a first core (26) and a second core (28) is built and configured to propagate the reflected light by the plurality of cores, a displacement amount measurement part (40) including a spectroscope (42) configured to separate the reflected light propagated by the first core into each wavelength components and a detector (44) having a plurality of light receiving elements arranged to correspond to a spectral direction by the spectroscope, and a peripheral image measurement part (60) configured to form an image of the reflected light propagated by the second core on the plurality of image pickup elements and to generate a peripheral image with respect to a measurement position of the measurement surface.

公开(公告)号：US20180160040A1

公开(公告)日：2018-06-07

申请号：US15878939

申请日：2018-01-24

Applicant: Corephotonics Ltd.

Inventor： Gal Shabtay ,  Noy Cohen ,  Oded Gigushinski ,  Ephraim Goldenberg

IPC: H04N5/232 ,  G06T5/20 ,  H04N9/09 ,  H04N9/04 ,  G06T7/33 ,  H04N5/225 ,  G06T11/60

CPC classification number: H04N5/23232 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0248 ,  G01J3/18 ,  G01J3/2823 ,  G01J3/36 ,  G02B5/1814 ,  G02B5/1842 ,  G06T5/20 ,  G06T7/33 ,  G06T7/337 ,  G06T11/60 ,  G06T2207/20221 ,  H04N5/2254 ,  H04N5/2258 ,  H04N5/23238 ,  H04N5/23296 ,  H04N5/332 ,  H04N9/045 ,  H04N9/09 ,  H04N9/097 ,  H04N9/735 ,  H04N2209/045

Abstract: A multi-aperture imaging system comprising a first camera with a first sensor that captures a first image and a second camera with a second sensor that captures a second image, the two cameras having either identical or different FOVs. The first sensor may have a standard color filter array (CFA) covering one sensor section and a non-standard color CFA covering another. The second sensor may have either Clear or standard CFA covered sections. Either image may be chosen to be a primary or an auxiliary image, based on a zoom factor. An output image with a point of view determined by the primary image is obtained by registering the auxiliary image to the primary image.

公开(公告)号：US20180153408A1

公开(公告)日：2018-06-07

申请号：US15504057

申请日：2016-05-10

Applicant: Ze Shan YAO ,  Piotr KUCHNIO ,  Michael Frank Gunter WOOD ,  Tammy Kee-Wai LEE ,  Yanhui BAI ,  Michael Peter BULK ,  Christopher Thomas JAMIESON

Inventor： Ze Shan YAO ,  Piotr KUCHNIO ,  Michael Frank Gunter WOOD ,  Tammy Kee-Wai LEE ,  Yanhui BAI ,  Michael Peter BULK ,  Christopher Thomas JAMIESON

IPC: A61B5/00 ,  A61B34/20

CPC classification number: A61B5/0075 ,  A61B5/0042 ,  A61B5/0071 ,  A61B5/0077 ,  A61B5/0082 ,  A61B5/0084 ,  A61B5/026 ,  A61B5/061 ,  A61B5/725 ,  A61B5/7425 ,  A61B5/748 ,  A61B17/34 ,  A61B34/20 ,  A61B90/20 ,  A61B90/361 ,  A61B2034/2055 ,  A61B2090/309 ,  A61B2562/0233 ,  A61B2562/0242 ,  G01J3/0248 ,  G01J3/10 ,  G01J3/2803 ,  G01J3/2823 ,  G01J2003/106 ,  G01J2003/2826

Abstract: A multispectral synchronized imaging system is provided. A multispectral light source of the system includes: blue, green and red LEDs, and one or more non-visible light sources, each being independently addressable and configured to emit, in a sequence: at least visible white light, and non-visible light in one or more given non-visible frequency ranges. The system further includes a camera and an optical filter arranged to filter light received at the camera, by: transmitting visible light from the LEDs; filter out non-visible light from the non-visible light sources; and otherwise transmit excited light emitted by a tissue sample excited by non-visible light. Images acquired by the camera are output to a display device. A control unit synchronizes acquisition of respective images at the camera for each of blue light, green light, visible white light, and excited light received at the camera, as reflected by the tissue sample.

公开(公告)号：US20180146858A1

公开(公告)日：2018-05-31

申请号：US15877722

申请日：2018-01-23

Applicant: Speclipse, Inc.

Inventor： Sung Hyun PYUN ,  Wanki MIN

IPC: A61B5/00 ,  G01J3/02 ,  G01J3/443 ,  G01J3/28

CPC classification number: A61B5/0077 ,  A61B5/0075 ,  A61B5/441 ,  A61B5/7246 ,  A61B5/7282 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0248 ,  G01J3/0291 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/443 ,  G01J2003/282

Abstract: A disease diagnosis and skin age measurement apparatus includes: a first light collection unit; a second light collection unit; a spectrometer configured to measure a spectrum of the light which is collected by the second light collection unit; a spectrum data comparison unit for disease diagnosis configured to compare the spectrum measured by the spectrometer and reference spectrum data for disease diagnosis; a CCD; an image data comparison unit configured to compare the digital image converted by the CCD and a reference image; a disease diagnosis unit configured to determine whether there is a disease in the body tissue; and/or a spectrum data comparison unit for skin age measurement configured to measure skin age by comparing a spectrum measured by the spectrometer and reference spectrum data for skin age measurement, wherein the light projected onto the body tissue is collimate light.

公开(公告)号：US09907472B2

公开(公告)日：2018-03-06

申请号：US15258253

申请日：2016-09-07

Applicant: Speclipse, Inc.

Inventor： Sung Hyun Pyun ,  Wanki Min

IPC: A61B5/00 ,  G01J3/02 ,  G01J3/28 ,  G01J3/443

CPC classification number: A61B5/0077 ,  A61B5/0075 ,  A61B5/441 ,  A61B5/7246 ,  A61B5/7282 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0248 ,  G01J3/0291 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/443 ,  G01J2003/282 ,  G06F19/00

Abstract: A disease diagnosis and skin age measurement apparatus includes: a first light collection unit; a second light collection unit; a spectrometer configured to measure a spectrum of the light which is collected by the second light collection unit; a spectrum data comparison unit for disease diagnosis configured to compare the spectrum measured by the spectrometer and reference spectrum data for disease diagnosis; a CCD; an image data comparison unit configured to compare the digital image converted by the CCD and a reference image; a disease diagnosis unit configured to determine whether there is a disease in the body tissue; and/or a spectrum data comparison unit for skin age measurement configured to measure skin age by comparing a spectrum measured by the spectrometer and reference spectrum data for skin age measurement, wherein the light projected onto the body tissue is collimate light.

公开(公告)号：US20170017069A1

公开(公告)日：2017-01-19

申请号：US15209571

申请日：2016-07-13

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ANDREW M. SIEGEL ,  NANDINI RAJAN ,  ANGELA M. BELCHER ,  NEELKANTH M. BARDHAN

IPC: G02B21/16 ,  G02B21/06 ,  G02B21/00 ,  A61B5/00

CPC classification number: G02B21/16 ,  A61B5/0071 ,  A61B5/0075 ,  G01J3/0208 ,  G01J3/0248 ,  G01J3/0264 ,  G01J3/10 ,  G01J3/108 ,  G01J3/2823 ,  G01J3/4406 ,  G01J2003/104 ,  G01J2003/106 ,  G01N21/6456 ,  G02B21/0012 ,  G02B21/06

Abstract: System and method configured to operate under conditions when the object being imaged destroys or negates the information which otherwise allows the user to take advantage of optical parallax, configured to elicit luminescence from the same targets in the object as a result of irradiation of these targets with pump light at different, respectively corresponding wavelengths, and acquire optical data from so-illuminated targets through the very same optical path to image the object at different wavelengths. One embodiment enables acquisition, by the same optical detector and from the same object, of imaging data that includes a reflectance image and multiple fluorescence-based images caused by light at different wavelengths, to assess difference in depths of locations of targets within the object.

Abstract translation: 被配置为在成像对象的条件下操作的系统和方法能够破坏或否定否则允许用户利用光学视差的信息，该信息被配置为通过这些目标的照射从对象中的相同目标引出发光， 以不同的分别对应的波长泵浦光，并且通过相同的光路从所照射的目标获取光学数据，以对不同波长的物体进行成像。 一个实施例使得能够通过相同的光学检测器和相同的对象采集包括反射图像和由不同波长的光引起的多个基于荧光的图像的成像数据，以评估对象内的目标位置的深度差异。