公开(公告)号：US09548192B2

公开(公告)日：2017-01-17

申请号：US14936223

申请日：2015-11-09

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

IPC: H01J49/04 ,  H01J49/06 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

CPC classification number: H01J49/067 ,  H01J49/06 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

Abstract translation: 本发明一般涉及用于聚焦或高于环境压力的离子的装置及其使用方法。 在某些实施例中，本发明提供了一种用于聚焦离子的装置，其包括具有空腔的电极，该电极内的至少一个入口配置成可操作地与电离源耦合，使得由电离源产生的放电注入到 电极和出口。 电极中的空腔成形为使得在向电极施加电压时，空腔内的离子被聚焦并引导到出口，该出口定位成使得出口的近端接收聚焦离子，并且远端 出口开放到环境压力。

公开(公告)号：US09484195B2

公开(公告)日：2016-11-01

申请号：US14880613

申请日：2015-10-12

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Robert Graham Cooks ,  Sandilya Venkata Garimella ,  Jason David Harper ,  Nicholas Alan Charipar

IPC: H01J49/04 ,  H01J49/26 ,  H01J49/00 ,  H01J49/40 ,  G01N27/62 ,  H01J49/42 ,  H01J49/10

CPC classification number: H01J49/0404 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0459 ,  H01J49/10 ,  H01J49/26 ,  H01J49/40 ,  H01J49/4215

Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.

公开(公告)号：US20160314956A1

公开(公告)日：2016-10-27

申请号：US15104405

申请日：2014-12-22

Applicant: PURDUE RESEARCH FOUNDATION ,  INDIAN INSTITUTE OF TECHNOLOGY MADRAS

Inventor： Robert Graham Cooks ,  Depanjan Sarkar ,  Thalappil Pradeep ,  Rahul Narayanan

IPC: H01J49/16 ,  H05K1/18 ,  H01J49/00

CPC classification number: H01J49/165 ,  H01J49/0013 ,  H01J49/0409 ,  H01J49/0431 ,  H01J49/16 ,  H05K1/18

Abstract: The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate.

Abstract translation: 本发明一般涉及用于电离样品的质谱探针和系统。 在某些实施方案中，本发明提供了一种质谱探针，其包括基材，其中基材的一部分涂覆有材料，其一部分从基材突出。

公开(公告)号：US09230792B2

公开(公告)日：2016-01-05

申请号：US14512579

申请日：2014-10-13

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Zhiping Zhang

IPC: H01J49/00 ,  H01J49/16 ,  H01J49/04

CPC classification number: G01N30/95 ,  G01N30/91 ,  G01N33/49 ,  H01J49/0031 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0431 ,  H01J49/167 ,  H01J49/168

Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.

公开(公告)号：US09159540B2

公开(公告)日：2015-10-13

申请号：US14594217

申请日：2015-01-12

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Robert Graham Cooks ,  Sandilya Venkata Garimella ,  Jason David Harper ,  Nicholas Alan Charipar

IPC: H01J49/04

CPC classification number: H01J49/0404 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0459 ,  H01J49/10 ,  H01J49/26 ,  H01J49/40 ,  H01J49/4215

Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.

公开(公告)号：US09064674B2

公开(公告)日：2015-06-23

申请号：US14277191

申请日：2014-05-14

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Jason David Harper ,  Nicholas Alan Charipar ,  Robert Graham Cooks

IPC: H01J49/26 ,  H01J37/32 ,  H01J37/00 ,  H05H1/24 ,  H05H1/30 ,  H01J49/10 ,  H01J49/14 ,  H01J27/02 ,  H01J49/02

CPC classification number: H01J37/32009 ,  H01J27/022 ,  H01J37/00 ,  H01J37/32348 ,  H01J49/02 ,  H01J49/105 ,  H01J49/142 ,  H01J2237/0044 ,  H05H1/24 ,  H05H1/2406 ,  H05H1/30 ,  H05H2001/2412 ,  H05H2001/2443 ,  H05H2240/10 ,  H05H2240/20 ,  Y10T436/145555 ,  Y10T436/147777 ,  Y10T436/173076 ,  Y10T436/203332 ,  Y10T436/24

Abstract: The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.

Abstract translation: 本发明一般涉及用于解吸和电离样品中至少一种分析物的低温等离子体探针及其使用方法。 在一个实施方案中，本发明一般涉及一种低温等离子体探针，其包括：壳体，其具有放电气体入口端口，探针尖端，两个电极和介电屏障，其中两个电极由电介质屏障隔开， 来自电源的电压的施加产生低温等离子体，其中通过电场和/或放电气体流将低温等离子体推出排出区域。

公开(公告)号：US20150147776A1

公开(公告)日：2015-05-28

申请号：US14594233

申请日：2015-01-12

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Robert Graham Cooks ,  Ahmed Mohamed Hamid ,  Alan Keith Jarmusch ,  Zheng Ouyang

IPC: H01J49/00 ,  H01J49/04

CPC classification number: H01J49/0036 ,  C12Q1/04 ,  G01N2560/00 ,  H01J49/04 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.

Abstract translation: 本发明一般涉及样品中微生物的质谱分析系统和方法。

公开(公告)号：US08937288B1

公开(公告)日：2015-01-20

申请号：US14481483

申请日：2014-09-09

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Ahmed Mohamed Hamid ,  Alan Keith Jarmusch ,  Zheng Ouyang

IPC: H01J49/16 ,  H01J49/04 ,  C12Q1/04 ,  H01J49/26

CPC classification number: H01J49/0036 ,  C12Q1/04 ,  G01N2560/00 ,  H01J49/04 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.

Abstract translation: 本发明一般涉及样品中微生物的质谱分析系统和方法。

公开(公告)号：US20150017712A1

公开(公告)日：2015-01-15

申请号：US14481483

申请日：2014-09-09

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Robert Graham Cooks ,  Ahmed Mohamed Hamid ,  Alan Keith Jarmusch ,  Zheng Ouyang

IPC: C12Q1/04 ,  H01J49/04 ,  H01J49/26

CPC classification number: H01J49/0036 ,  C12Q1/04 ,  G01N2560/00 ,  H01J49/04 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.

公开(公告)号：US20140231643A1

公开(公告)日：2014-08-21

申请号：US14227563

申请日：2014-03-27

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Zheng Ouyang ,  Liang Gao ,  Robert Graham Cooks

IPC: H01J49/04 ,  H01J49/10 ,  H01J49/00

CPC classification number: H01J49/24 ,  H01J49/00 ,  H01J49/0013 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/04 ,  H01J49/0404 ,  H01J49/0422 ,  H01J49/0495 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

Abstract: A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure.

Abstract translation: 将大气压力离子源（包括电喷雾和解吸电喷雾离子源）与将其离子化样品不连续地引入质谱仪的质谱仪（例如微型质谱仪）进行接口的方法。 不连续的介绍改善了仪器的抽吸能力与含有电离样品的大气压气体的体积之间的匹配。 样品引入的减少的占空比通过质谱仪在较高性能条件下的操作和大气压下的离子积聚来抵消。