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公开(公告)号：US20240331992A1
公开(公告)日：2024-10-03
申请号：US18293399
申请日：2022-07-28
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Peter KOVARIK , John J. CORR
CPC classification number: H01J49/045 , H01J49/167
Abstract: A liquid handling system for a mass spectrometer (MS), the liquid handling system including an open port interface (OPI) including a body defining a port and an internal volume. At least one removal conduit is disposed in the body and fluidically coupled to the internal volume. A plurality of transfer conduits is fluidically coupled to the at least one removal conduit. A single one of a plurality of nebulizer nozzles are fluidically coupled to each of the plurality of transfer conduits.
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公开(公告)号：US20240312774A1
公开(公告)日：2024-09-19
申请号：US18268438
申请日：2021-09-24
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Peter Kovarik , Thomas Covey , Gordana Ivosev , Chang Liu
CPC classification number: H01J49/0418 , H01J49/0036
Abstract: Systems and methods are disclosed for timed introduction of samples into a mass spectrometer may include receiving a plurality of sample ion pulses in a mass spectrometer from a sampling interface, where the sample ion pulses are received at a pre-determined time pattern; detecting the received sample ion pulses to generate a signal; isolating an analyte signal by signal conditioning the generated signal based on the pre-determined time pattern; and identifying a presence of an analyte based on the isolated analyte signal. The signal conditioning may include pulse-based averaging based on the pre-determined time pattern or may include converting the generated signal to a frequency-domain signal and calculating a modulus to isolate the analyte signal. The pre-determined time pattern may be periodic where the signal conditioning comprises performing a Fourier Transform on the signal to convert it to a frequency-domain signal.
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公开(公告)号：US20240297028A1
公开(公告)日：2024-09-05
申请号：US18589559
申请日：2024-02-28
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Scott DANIELS , Aaron STELLA , Michal WEINSTOCK
IPC: H01J49/00 , G06F3/0484
CPC classification number: H01J49/0009 , G06F3/0484
Abstract: A method for calibrating a mass spectrometry (MS) system includes: receiving at least one input through a corresponding to a calibrator in a sample, wherein the sample includes an analyte, and wherein the sample is analyzed by the MS system; automatically determining a plurality of transitions in the sample corresponding to the calibrator according to natural abundances of isotopes; automatically determining concentrations of the plurality of transitions according to a concentration of the calibrator in the sample; identifying a plurality of transitions as calibrator transitions and for identifying a different one of the plurality of transitions as an internal standard; detecting a concentration of each of the plurality of transitions and the calibrator in the sample; automatically calibrating the MS system based in part on the detected concentrations of the plurality of calibrator transitions and the internal standard; and detecting the concentration of the analyte in response to execution of the calibration instructions.
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公开(公告)号：US20240290600A1
公开(公告)日：2024-08-29
申请号：US18278544
申请日：2022-02-23
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Aaron Timothy BOOY , James HAGER
IPC: H01J49/06
CPC classification number: H01J49/062
Abstract: In one aspect, an ion guide for use in a mass spectrometer is disclosed, which comprises a first plurality of conductive electrodes disposed on a first surface, a second plurality of conductive electrodes disposed on a second surface, wherein the two surfaces are positioned relative to one another and shaped so as to provide a passageway having an inlet for receiving an ion beam and an outlet through which target ions of interest exit the passageway. The ion guide further includes an orifice formed in at least one of those surfaces through which neutral species and/or large ion clusters, when present in the ion beam, exit the ion guide.
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公开(公告)号：US12072725B2
公开(公告)日：2024-08-27
申请号：US17762244
申请日：2020-09-24
Applicant: DH Technologies Development PTE. LTD.
Inventor： Manuel Faur , Ernesto Gradin
Abstract: In one aspect, a voltage regulator is disclosed, which comprises a first voltage regulator unit configured for regulating a voltage generated by a positive high voltage source, a second voltage regulator unit configured for regulating a voltage generated by a negative high voltage source, a polarity switch for connecting said first and second voltage regulator units to said positive and negative high voltage sources, respectively, and an output voltage port for receiving a regulated positive and negative high voltage from said first and said second voltage regulator units, respectively.
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Patent Agency Ranking
16.发明公开公开(公告)号：US20240272121A1
公开(公告)日：2024-08-15
申请号：US18569701
申请日：2022-06-16
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Bradley B. SCHNEIDER , Leigh BEDFORD , Yves LE BLANC , Eva DUCHOSLAV
IPC: G01N27/623 , G01N27/624 , H01J49/00
CPC classification number: G01N27/623 , G01N27/624 , H01J49/0031
Abstract: An automated method of operating a mass spectrometer (MS) comprising a differential mobility spectrometer (DMS) includes: introducing a first compound to the DMS; calculating a first alpha function for the first compound; introducing a second compound to the DMS; calculating a second alpha function for the second compound; and determining operation parameters of the DMS to achieve sufficient separation of the first compound and the second compound, based on the first alpha function and the second alpha function.
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公开(公告)号：US20240272101A1
公开(公告)日：2024-08-15
申请号：US18568410
申请日：2022-06-08
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas COVEY , Chang LIU , Yuzhu GUO
IPC: G01N23/2208 , G16C20/30
CPC classification number: G01N23/2208 , G16C20/30 , G01N2223/071
Abstract: In one aspect, a method of assessing hydrophobicity of a target analyte is disclosed, which includes introducing a sin-gle-phase system containing a concentration of the target analyte into a mass spectrometer to acquire at least one mass signal associated with the target analyte, introducing a phase-separated system (e.g., a two-phase system) containing substantially the same concentration of the target analyte into the mass spectrometer to acquire at least one mass signal associated with said target analyte, and utilizing a ratio of the intensities of the mass signals to assess hydrophobicity of the target analyte.
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公开(公告)号：US20240234123A1
公开(公告)日：2024-07-11
申请号：US18037582
申请日：2021-11-17
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Bruce COLLINGS , James HAGER , Yang KANG , Bradley B. SCHNEIDER
CPC classification number: H01J49/4215 , H01J49/0031 , H01J49/24 , H01J49/0086
Abstract: A mass spectrometer comprises a first mass filter for receiving a plurality of ions and having a transmission bandwidth configured to allow transmission of ions having m/z ratios within a desired range, and a second mass filter that is disposed downstream of the first mass filter for selecting ions having a target m/z value within a transmission window thereof for mass analysis. The transmission bandwidth of the first mass filter encompasses at least two m/z ratios of interest such that one of said m/z ratios corresponds to said target m/z value within the transmission window of said second mass filter.
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公开(公告)号：US20240230633A1
公开(公告)日：2024-07-11
申请号：US18562090
申请日：2022-05-18
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Aaron STELLA , Subhasish PURKAYASTHA
IPC: G01N33/543 , G01N33/94
CPC classification number: G01N33/54326 , G01N33/54353 , G01N33/94
Abstract: Methods and kits for preparing liquid samples are presently claimed and described. The method may include treating a liquid sample with enzyme-conjugated magnetic beads are suspended in a buffer solution that comprises at least one internal standard, hydrolyzing the liquid sample to prepare a hydrolysate, and purifying the hydrolysate with magnetic based purification. Kits for preparing a liquid sample can include the, a liquid chromatography column, one or more solvents to be used as mobile phases, one or more calibrant solutions, and instructions for use.
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公开(公告)号：US12002672B2
公开(公告)日：2024-06-04
申请号：US16630007
申请日：2018-06-29
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Bruce Collings , Pascal Martin
CPC classification number: H01J49/067 , H01J49/0031 , H01J49/4225 , H01J49/426
Abstract: Apparatus and methods for controlling contamination of components contained within the high-vacuum chambers of mass spectrometer systems are provided. The apparatus and methods employ a beam of neutral gas injected in a contra-flow configuration to incoming particle stream from the ionization chamber. The contra-flow can be in the directly opposite counter-flow direction (e.g., 180 degrees) or at a cross-flow angle to the incoming ion stream (e.g., flowing at an angle between about 10 degrees and 170 degrees). The contra-flow disrupts the axial gas flow and diverts neutral molecules and other undesirable contaminants before they reach the high vacuum stages (e.g., beyond the IQ0 orifice) of the spectrometer. By reducing the transmission of contaminants into the sensitive components housed deep within the mass spectrometer, the present invention can increase throughput, improve robustness, and/or decrease the downtime typically required to vent/disassemble/clean the fouled components.
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