公开(公告)号：US10111986B2

公开(公告)日：2018-10-30

申请号：US15293583

申请日：2016-10-14

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Niraj Gurung ,  David R. Wulfman ,  Adegbola O. Adenusi ,  Patrick Willoughby ,  Adeniyi O. Aremu

IPC: A61L31/06 ,  A61L31/10 ,  A61N1/05 ,  C08G81/02 ,  A61L29/08 ,  C08G18/66 ,  C08G18/76 ,  C08G18/12 ,  C08G18/24 ,  C08G18/32

Abstract: A method for making a device including a polyisobutylene-polyurethane block copolymer. The method includes polymerizing a polyisobutylene diol, a diisocyanate, and a chain extender within a solvent system to form a polyisobutylene-polyurethane block copolymer solution, depositing the polyisobutylene-polyurethane block copolymer solution onto at least a portion of the device, and evaporating the solvent system from the deposited polyisobutylene-polyurethane block copolymer solution.

公开(公告)号：US20170174845A1

公开(公告)日：2017-06-22

申请号：US15382254

申请日：2016-12-16

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Niraj Gurung ,  Patrick Willoughby ,  David R. Wulfman ,  Adegbola O. Adenusi ,  Adeniyi O. Aremu

IPC: C08G81/02 ,  A61L29/06

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer and a tertiary amine catalyst. The polyisobutylene-polyurethane block copolymer includes soft segments including at least one polyisobutylene diol residue, and hard segments including at least one diisocyanate residue. The polymeric material is free of an organometallic catalyst.

公开(公告)号：US11324860B2

公开(公告)日：2022-05-10

申请号：US15672674

申请日：2017-08-09

Applicant: Cardiac Pacemakers, Inc.

Inventor： David R. Wulfman ,  Danielle Frankson ,  Adeniyi O. Aremu ,  Angelo Fruci ,  Gregory J. Sherwood ,  Mary M. Byron ,  Joseph T. Delaney, Jr. ,  Adam McGraw

IPC: A61L29/16 ,  A61L31/06 ,  A61L31/04 ,  A61L31/10 ,  A61F2/30 ,  A61L27/28

Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.

公开(公告)号：US11155933B2

公开(公告)日：2021-10-26

申请号：US16233544

申请日：2018-12-27

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Jeannette C. Polkinghorne ,  Adegbola O. Adenusi ,  David R. Wulfman ,  Kasyap Seethamraju

IPC: A61N1/05 ,  D01D5/00

Abstract: A medical electrical lead includes an insulative lead body extending from a distal region to a proximal region and a conductor disposed within the insulative lead body and extending from the proximal region to the distal region. An electrode is disposed on the insulative lead body and is in electrical contact with the conductor. The medical electrical lead also includes a cross-linked hydrophilic polymer coating disposed over at least a portion of the electrode. The cross-linked hydrophilic polymer coating includes a fibrous matrix comprising a plurality of discrete fibers and pores formed between at least a portion of the fibers and a hydrophilic polyethylene glycol-containing hydrogel network disposed within the pores of the fibrous matrix.

公开(公告)号：US10335513B2

公开(公告)日：2019-07-02

申请号：US15624102

申请日：2017-06-15

Applicant: Cardiac Pacemakers, Inc.

Inventor： Danielle Frankson ,  Joseph T. Delaney, Jr. ,  Mary M. Byron ,  Adam McGraw ,  David R. Wulfman ,  Kylee M. Lersch

IPC: A61L27/34 ,  A61L27/06 ,  A61L27/04 ,  A61L31/02 ,  A61L31/10 ,  C09D5/16 ,  C09D123/06 ,  C08L71/02

Abstract: A coating for a roughened metal surface of an implantable medical device includes a poly(ethylene glycol) disposed on at least a portion of the roughened metal surface, wherein the poly(ethylene glycol) is covalently bonded directly to the roughened metal surface.

公开(公告)号：US09855415B2

公开(公告)日：2018-01-02

申请号：US15217178

申请日：2016-07-22

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  David R. Wulfman ,  Adeniyi O. Aremu ,  Adegbola O. Adenusi

IPC: A61N1/00 ,  A61N1/05 ,  D01D5/24

CPC classification number: A61N1/05 ,  A61N1/056 ,  D01D5/24

Abstract: A medical electrical lead includes an insulative lead body extending from a distal region to a proximal region, a conductor disposed within the insulative lead body and extending from the proximal region to the distal region, an electrode disposed on the insulative lead body and in electrical contact with the conductor, and a fibrous matrix disposed on at least part of the electrode. The fibrous matrix includes fibers. The fibers include a polyvinylidene fluoride-based (PVDF-based) polymer and a crystal-modifying additive. The PVDF-based polymer includes an amorphous PVDF phase and a crystalline PVDF phase. The crystalline PVDF phase includes a beta form crystalline structure in an amount exceeding any other crystalline structure form in the crystalline PVDF phase.

公开(公告)号：US11851522B2

公开(公告)日：2023-12-26

申请号：US17951682

申请日：2022-09-23

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Andrew J. Ro ,  David R. Wulfman ,  Niraj Gurung ,  Patrick Willoughby

IPC: C08G18/28 ,  C08G18/12 ,  C08G18/62 ,  C08G18/48 ,  A61L31/14 ,  C08G18/76 ,  A61L31/12 ,  C08G18/40 ,  A61L29/04 ,  C08G18/83 ,  A61L31/04 ,  A61L27/16

CPC classification number: C08G18/6208 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  A61L31/129 ,  A61L31/143 ,  C08G18/12 ,  C08G18/2865 ,  C08G18/4063 ,  C08G18/4808 ,  C08G18/4854 ,  C08G18/6204 ,  C08G18/7671 ,  C08G18/833 ,  C08G18/12 ,  C08G18/3206 ,  C08G18/12 ,  C08G18/2865 ,  A61L27/16 ,  C08L53/00 ,  A61L31/048 ,  C08L53/00 ,  A61L29/041 ,  C08L53/00

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

公开(公告)号：US11660379B2

公开(公告)日：2023-05-30

申请号：US17701421

申请日：2022-03-22

Applicant: Cardiac Pacemakers, Inc.

Inventor： David R. Wulfman ,  Danielle Frankson ,  Adeniyi O. Aremu ,  Angelo Fruci ,  Gregory J. Sherwood ,  Mary M. Byron ,  Joseph T. Delaney, Jr. ,  Adam McGraw

IPC: A61L24/00 ,  B05D3/00 ,  A61L29/16 ,  A61L31/06 ,  A61L31/04 ,  A61L31/10 ,  B05D3/06 ,  B05D3/10 ,  A61F2/30 ,  A61L27/28 ,  B05D3/02

CPC classification number: A61L29/16 ,  A61F2/30767 ,  A61L27/28 ,  A61L31/046 ,  A61L31/06 ,  A61L31/10 ,  B05D3/007 ,  B05D3/061 ,  B05D3/108 ,  A61F2002/30677 ,  A61L2300/606 ,  A61L2400/12 ,  A61L2420/02 ,  A61M2207/00 ,  B05D3/0254 ,  B05D2518/00 ,  A61L31/10 ,  C08L71/02 ,  A61L31/06 ,  C08L75/04 ,  A61L31/046 ,  C08L27/12

Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.

公开(公告)号：US11472911B2

公开(公告)日：2022-10-18

申请号：US16248498

申请日：2019-01-15

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Andrew J. Ro ,  David R. Wulfman ,  Niraj Gurung ,  Patrick Willoughby

IPC: C08G18/28 ,  C08G18/62 ,  C08G18/48 ,  A61L31/14 ,  C08G18/76 ,  A61L31/12 ,  C08G18/40 ,  C08G18/12 ,  A61L29/04 ,  C08G18/83 ,  A61L31/04 ,  A61L27/16

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

公开(公告)号：US10518004B2

公开(公告)日：2019-12-31

申请号：US15843673

申请日：2017-12-15

Applicant: Cardiac Pacemakers, Inc.

Inventor： Mary M. Byron ,  David R. Wulfman ,  Angelo Fruci ,  Adam McGraw ,  Danielle Frankson ,  Gregory J. Sherwood ,  Joseph T. Delaney, Jr. ,  Adeniyi O. Aremu

IPC: A61L31/16 ,  A61L31/14 ,  A61L31/04 ,  A61N1/05 ,  D01D5/00

Abstract: An implantable drug eluting medical device includes a polymer substrate having a surface, a first plurality of nanofibers, and at least one antimicrobial drug. Each of the first plurality of nanofibers includes a first portion interpenetrated with the surface of the substrate to mechanically fix the nanofiber to the substrate, and a second portion projecting from the surface. The at least one antimicrobial drug is disposed within or among the second portion of the first plurality of nanofibers.