公开(公告)号：US09861286B1

公开(公告)日：2018-01-09

申请号：US15686198

申请日：2017-08-25

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  A61B5/00 ,  G01N33/49 ,  G01N33/44 ,  G01N33/15 ,  G01N33/02 ,  G01N21/88 ,  G01N21/3563 ,  G01N21/359 ,  G01J3/453 ,  A61B5/145 ,  A61B5/1455 ,  H01S3/30 ,  G01N21/39 ,  G01M3/38 ,  G01J3/28 ,  G01J3/10 ,  G01J3/18 ,  G01J3/14

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A wearable device for use with a smart phone or tablet includes LEDs for measuring physiological parameters by modulating the LEDs and generating a near-infrared multi-wavelength optical beam. At least one LED emits at a first wavelength having a first penetration depth and at least another LED emits at a second wavelength having a second penetration depth into tissue. The device includes lenses that deliver the optical beam to the tissue, which reflects the first and second wavelengths. A receiver is configured to capture light while the LEDs are off and while at least one of the LEDs is on and to difference corresponding signals to improve a signal-to-noise ratio of the optical beam reflected from the tissue. The signal-to-noise ratio is further increased by increasing light intensity of at least one of the LEDs. The device generates an output signal representing a non-invasive measurement on blood within the tissue.

公开(公告)号：US09857225B2

公开(公告)日：2018-01-02

申请号：US14663882

申请日：2015-03-20

Applicant: IMACC, LLC

Inventor： William F. Pearman ,  Scott A. Evans ,  Daniel J. Pearson

IPC: G01J3/45 ,  G01B9/02 ,  G01J3/453 ,  G01N21/3504 ,  H04B1/403

CPC classification number: G01J3/453 ,  G01J2003/4534 ,  G01N21/3504 ,  G01N2201/06113 ,  H04B1/406

Abstract: A system. The system includes a first beam path configured to transmit a first light beam having a first optical wavelength and a second beam path configured to transmit a second light beam having a second optical wavelength distinct from the first optical wavelength. A first beam splitter disposed at an intersection of the first beam path and the second beam path. The first beam splitter is configured to superimpose the first and second light beams to form a third light beam, the third light beam impinging on a first window of a sample cell. The sample cell defines an interior volume and is configured to transfer the third light beam from the first window to a second window along a light path within the interior volume. The light path comprises a plurality of segments. The third light beam undergoes at least one reflection at an end of each segment, wherein the light path passes through a gas sample disposed within the interior volume.

公开(公告)号：US09709440B2

公开(公告)日：2017-07-18

申请号：US14325502

申请日：2014-07-08

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Dirk Robert Englund ,  Edward H. Chen ,  Fan Meng ,  Tim Schroder ,  Noel Heng Loon Wang ,  Ren-Jye Shiue

IPC: G01J3/02 ,  G01J3/453 ,  G02B6/42 ,  G02B6/293

CPC classification number: G01J3/0205 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/453 ,  G02B6/29344 ,  G02B6/4287

Abstract: Multimode interference can be used to achieve ultra-high resolving powers (e.g., Q>105) with linewidths down to 10 pm at 1500 nm and a broad spectroscopy range (e.g., 400-2400 nm) within a monolithic, millimeter-scale device. For instance, multimode interference (MMI) in a tapered waveguide enables fine resolution and broadband spectroscopy in a compact, monolithic device. The operating range is limited by the transparency of the waveguide material and the sensitivity of the camera; thus, the technique can be easily extended into the ultraviolet and mid- and deep-infrared spectrum. Experiments show that a tapered fiber multimode interference spectrometer can operate across a range from 500 nm to 1600 nm (B=1.0576) without moving parts. The technique is suitable for on-chip tapered multimode waveguides, which could be fabricated in high volume by printing or optical lithography, for applications from biochemical sensing to the life and physical sciences.

公开(公告)号：US09683891B2

公开(公告)日：2017-06-20

申请号：US12935772

申请日：2009-03-17

Applicant: Yassine Hadjar ,  Sylvain Blaize ,  Aurelien Bruyant ,  Gilles Lerondel ,  Pascal Royer

Inventor： Yassine Hadjar ,  Sylvain Blaize ,  Aurelien Bruyant ,  Gilles Lerondel ,  Pascal Royer

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/453 ,  G01J3/45

CPC classification number: G01J3/0205 ,  G01J3/02 ,  G01J3/021 ,  G01J3/2803 ,  G01J3/45 ,  G01J3/453

Abstract: A spectrometer for sampling interferograms in two dimensions offering a large spectral band and high spectral resolution with a relative compactness. The spectrometer includes a refracting surface, an array of detecting elements and an array of diffusion elements capturing means at the refracting surface of an interferogram delivered from two interference beams (F1, F2) and forming interference lines parallel to each other along the transverse axis (Ox) of the interferogram within the plane (xOy) of the refracting surface, the array of detection elements being parallel to the plane of the refracting surface and arranged to detect the spatial distribution of the interferogram, wherein the array is a two-dimensional array over an entirety of which the detections elements are disposed equidistantly, and wherein interference lines exhibit an angular shift with the capturing means.

公开(公告)号：US09658162B2

公开(公告)日：2017-05-23

申请号：US14642655

申请日：2015-03-09

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： H. Kumar Wickramasinghe

IPC: G01N21/65 ,  G01J3/44 ,  G01J3/45 ,  G01Q30/02

CPC classification number: G01N21/65 ,  G01J3/0224 ,  G01J3/44 ,  G01J3/45 ,  G01J3/453 ,  G01J9/0215 ,  G01J2009/0261 ,  G01N2021/655 ,  G01Q30/02

Abstract: An apparatus and method for measuring amplitude and/or phase of a molecular vibration uses a polarization modulated pump beam and a stimulating Stokes beam on a probe of a scanning probe microscope to detect a Raman scattered Stokes beam from the sample. The detected Raman scattered Stokes beam is used to derive at least one of the amplitude and the phase of the molecular vibration.

公开(公告)号：US09651533B2

公开(公告)日：2017-05-16

申请号：US14875709

申请日：2015-10-06

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J5/20 ,  G01N33/15 ,  A61B5/1455 ,  A61B5/00 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  A61B5/145 ,  G01N33/49 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A measurement system includes a wearable measurement device for measuring one or more physiological parameters, including a light source comprising a plurality of light emitting diodes (LEDs) configured to generate an output optical beam with a near-infrared wavelength between 700 nanometers and 2500 nanometers. The light source is configured to increase signal-to-noise ratio by increasing a light intensity and pulse rate of the LEDs. The system includes a plurality of lenses configured to receive the output optical beam and to deliver an analysis output beam to a sample. The wearable measurement device includes a receiver configured to process the analysis output beam reflected or transmitted from the sample and to generate an output signal that may be transmitted to a remote device configured to process the received output status to generate processed data and to store the processed data.

公开(公告)号：US09588099B2

公开(公告)日：2017-03-07

申请号：US13760193

申请日：2013-02-06

Applicant: Cambridge Research & Instrumentation, Inc.

Inventor： Richard Levenson ,  Paul J. Cronin

IPC: G01N21/64 ,  A61B5/00 ,  G01N33/483 ,  B82Y5/00 ,  B82Y10/00 ,  G01J3/32 ,  G01J3/44 ,  G01J3/453 ,  G01N21/25

CPC classification number: G01N33/4833 ,  A61B5/0059 ,  B82Y5/00 ,  B82Y10/00 ,  G01J3/32 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/255 ,  G01N21/6486 ,  G01N2201/062 ,  G01N2201/125

Abstract: Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral weightings, and subsequent spectral analysis, light emission from a target compound is separated from autofluorescence in the sample. With the autofluorescence reduced or eliminated, an improved measurement of the target compound is obtained.

Abstract translation: 提供了设备和方法，用于使用光谱成像提供高度敏感的检测来生物样本中深层组织中的结构成像。 通过获取提供具有不同光谱加权的样本的多个图像的数据和随后的光谱分析，来自目标化合物的光发射与样品中的自发荧光分离。 随着自发荧光降低或消除，获得目标化合物的改进的测量。

公开(公告)号：US09513167B2

公开(公告)日：2016-12-06

申请号：US14579832

申请日：2014-12-22

Applicant: Thermo Scientific Portable Analytical Instruments Inc.

Inventor： Michael Derek Hargreaves ,  Timothy M. Pastore ,  Gregory H. Vander Rhodes ,  Brendon D. Tower

IPC: G01N21/00 ,  G01J3/44 ,  G01J3/02 ,  G01J3/28 ,  G01J3/45 ,  G01N21/35 ,  G01N21/65 ,  G01J3/453

CPC classification number: G01J3/4412 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/28 ,  G01J3/44 ,  G01J3/45 ,  G01J3/453 ,  G01J2003/2833 ,  G01N21/35 ,  G01N21/65 ,  G01N2021/3595 ,  G01N2201/0221

Abstract: A spectrometer configurable for field analyses of chemical properties of a material is provided. The spectrometer includes: at least one sensor adapted for providing Fourier transform infrared spectroscopy (FTIR) surveillance and at least another sensor for providing Raman spectroscopy surveillance. The spectrometer can be provided with a user accessible instruction set for modifying a sampling configuration of the spectrometer. A method of determining the most likely composition of a sample by at least two technologies using the spectrometer is also provided.

Abstract translation: 提供了可配置用于材料的化学性质的现场分析的光谱仪。 光谱仪包括：适于提供傅里叶变换红外光谱（FTIR）监视的至少一个传感器和用于提供拉曼光谱监视的至少一个传感器。 光谱仪可以设置有用于修改光谱仪的采样配置的用户可访问指令集。 还提供了通过使用光谱仪的至少两种技术来确定样品的最可能组成的方法。

公开(公告)号：US09482577B2

公开(公告)日：2016-11-01

申请号：US14494315

申请日：2014-09-23

Applicant: University of Virginia Patent Foundation

Inventor： Brooks Hart Pate ,  Justin L. Neill

IPC: G01J3/30 ,  G01J3/443 ,  G01J3/28 ,  G01J3/433 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3586

CPC classification number: G01J3/443 ,  G01J3/2889 ,  G01J3/4338 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3586 ,  G01N2021/3595

Abstract: An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a specified downconversion local oscillator (LO) frequency using a digital-to-analog converter (DAC), upconverting the chirped waveform via mixing the chirped waveform with a specified upconversion LO frequency, frequency multiplying the upconverted chirped waveform to provide a chirped excitation signal for exciting the sample, receiving an emission from sample, the emission elicited at least in part by the chirped excitation signal, and downconverting the received emission via mixing the received emission with a signal based on the specified downconversion LO signal to provide a downconverted emission signal within the bandwidth of an analog-to-digital converter (ADC). The specified chirped waveform can include a first chirped waveform during a first duration, and a second chirped waveform during a second duration.

Abstract translation: 可以使用特定范围的激发频率响应于激发而从样品获得发射。 这种激励可以包括使用数模转换器（DAC）产生指定的啁啾波形和指定的下变频本地振荡器（LO）频率，通过将啁啾波形与指定的上变频LO频率混频来上变频啁啾波形， 上变频啁啾波形以提供用于激发采样的啁啾激励信号，接收来自采样的发射，至少部分地由啁啾激励信号引起的发射，以及通过基于指定的信号将接收到的发射与信号进行混合来下变频接收的发射 下变频LO信号，以在模数转换器（ADC）的带宽内提供下变频发射信号。 指定的啁啾波形可以包括第一持续时间期间的第一啁啾波形和第二持续时间内的第二啁啾波形。

公开(公告)号：US20160299007A1

公开(公告)日：2016-10-13

申请号：US13853896

申请日：2013-03-29

Applicant: Agilent Technologies, Inc.

Inventor： Adam Kleczewski

IPC: G01J3/453

CPC classification number: G01J3/453 ,  G01J3/027 ,  G01J2003/4538 ,  H01S5/14

Abstract: An optical measurement method in which a series of light pulses are generated using a pulsed laser having a set of different mode hop sequences (e.g., an external-cavity quantum cascade laser (EC-QCL)), the light pulses are detected with the detector to generate a respective pulse data set for each of the light pulses, and the pulse data sets are sorted into classes based on correlation coefficients. Sorting the pulse data sets into classes allows the pulse data sets originating from each of the mode hop sequences of the pulsed laser to be treated independently of the pulse data sets originating from others of the mode hop sequences in subsequent processing.

Abstract translation: 一种光学测量方法，其中使用具有一组不同模式跳跃序列的脉冲激光器（例如，外腔量子级联激光器（EC-QCL））产生一系列光脉冲，光检测器 以产生每个光脉冲的相应脉冲数据集，并且基于相关系数将脉冲数据集分类成类别。 将脉冲数据集分类成类允许在随后的处理中独立于源自其他模式跳序列的脉冲数据集来处理源自脉冲激光器的每个模跳序列的脉冲数据集。