公开(公告)号：US08760645B2

公开(公告)日：2014-06-24

申请号：US13114261

申请日：2011-05-24

Applicant: Garland Christian Misener ,  James Edward Milan ,  Robert W. Lachapelle

Inventor： Garland Christian Misener ,  James Edward Milan ,  Robert W. Lachapelle

IPC: G01J3/00 ,  G01J3/30 ,  G01N21/25

CPC classification number: G01J3/4406 ,  G01J3/28 ,  G01N21/64 ,  G01N2021/6417 ,  G01N2201/124

Abstract: A method of normalizing an analyzer response value of a fluorescence analyzer is provided. The method includes measuring an excitation spectrum of the analyzer and measuring an emission sensitivity spectrum of the analyzer. Next, a normalization factor based at least in part upon the excitation spectrum of the analyzer and the emission sensitivity spectrum of the analyzer is determined. The sample is then analyzed to obtain an uncorrected analyzer response value. A normalized analyzer response value is calculated based at least in part upon the uncorrected analyzer response value and the normalization factor.

Abstract translation: 提供了对荧光分析仪的分析仪响应值进行归一化的方法。 该方法包括测量分析仪的激发光谱并测量分析仪的发射灵敏度谱。 接下来，确定至少部分地基于分析仪的激发光谱和分析仪的发射灵敏度光谱的归一化因子。 然后分析样品以获得未校正的分析仪响应值。 至少部分地基于未校正的分析仪响应值和归一化因子计算归一化分析器响应值。

公开(公告)号：US5206711A

公开(公告)日：1993-04-27

申请号：US535934

申请日：1990-06-11

Applicant: John W. Berthold ,  Charles R. Dailey

Inventor： John W. Berthold ,  Charles R. Dailey

IPC: G01N21/53 ,  G01N21/85

CPC classification number: G01N21/8507 ,  G01N2021/1751 ,  G01N21/534 ,  G01N2201/0621 ,  G01N2201/08 ,  G01N2201/124 ,  G01N2201/12769

Abstract: A fiber optic fluid opacity sensor includes a light source (12) transmitting light to dividing means (14) for providing a sample light signal (18) and a reference light signal (20) to dual photodetectors (26, 28). Sample and reference optical pathways (19, 21) are defined by optical fibers (18, 20) spaced apart from and axially aligned with the photodetectors (26, 28) at a predetermined distance. Signal processing means (30) takes the log ratio output of the signals from the photodetectors (26, 28) for cancelling the effect of light source drift since the same source (12) is common to both for measuring the light transmission and determining opacity therefrom. A sample probe (40) contains the photodetectors (26, 28) and the sample and reference optical pathways (19, 21). The light source (12) and the signal processing means (30) are situated outside of the probe (40) and by virtue thereof outside of the sample process line (48).

Abstract translation: 光纤液体不透明度传感器包括将光传送到分割装置（14）的光源（12），用于向双光电检测器（26,28）提供采样光信号（18）和参考光信号（20）。 采样和参考光学路径（19,21）由在预定距离处与光电检测器（26,28）间隔开并且轴向对齐的光纤（18,20）限定。 信号处理装置（30）获取来自光电检测器（26,28）的信号的对数比输出，以消除光源漂移的影响，因为相同的源（12）对于测量光透射和确定不透明度是共同的 。 样品探针（40）包含光电检测器（26,28）和样品和参考光学通路（19,21）。 光源（12）和信号处理装置（30）位于探针（40）的外部，并且由于其位于样品处理线（48）之外。

公开(公告)号：US11686847B2

公开(公告)日：2023-06-27

申请号：US16775115

申请日：2020-01-28

Applicant: Cilag GmbH International

Inventor： Joshua D. Talbert ,  Donald M. Wichern

IPC: G01N21/64 ,  G01S17/89 ,  G06T7/521 ,  A61B1/00 ,  A61B1/04 ,  A61B1/05 ,  G01J3/28 ,  G06T1/00 ,  G01S7/48 ,  G01S7/483 ,  G01J3/44 ,  A61B5/00 ,  A61B1/06 ,  H04N23/56 ,  H04N23/74 ,  H04N23/60 ,  G01J3/12 ,  G01J3/42 ,  H04N23/50

CPC classification number: G01S17/89 ,  A61B1/00006 ,  A61B1/000095 ,  A61B1/00194 ,  A61B1/043 ,  A61B1/05 ,  A61B1/0655 ,  A61B5/0033 ,  A61B5/0071 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/6456 ,  G01S7/483 ,  G01S7/4804 ,  G06T1/0007 ,  G06T7/521 ,  H04N23/56 ,  H04N23/665 ,  H04N23/74 ,  G01J2003/1213 ,  G01J2003/2826 ,  G01J2003/423 ,  G01N2201/124 ,  G06T2207/10064 ,  G06T2207/10068 ,  G06T2207/30004 ,  H04N23/555

Abstract: Pulsed fluorescence imaging in a light deficient environment is disclosed. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a controller configured to synchronize timing of the emitter and the image sensor. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 795 nm to about 815 nm.

公开(公告)号：US09933358B2

公开(公告)日：2018-04-03

申请号：US13401047

申请日：2012-02-21

Applicant: Kanako Iwamura ,  Shoichi Kanayama

Inventor： Kanako Iwamura ,  Shoichi Kanayama

IPC: G01N21/59 ,  G01N21/25 ,  G01N35/02 ,  G01N35/04

CPC classification number: G01N21/253 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/0455 ,  G01N2201/0415 ,  G01N2201/124 ,  G01N2201/1245 ,  G01N2201/127

Abstract: According to one embodiment, an automatic analyzer comprises a light source, a spectroscope, a photo detection unit, a storage unit, a selection unit, and a calculation unit. The storage unit stores photo detector identifiers related to photo detectors and wavelength band identifiers in association with each other. The selection unit selects a specific photo detector from photo detectors. The specific photo detector corresponds to a specific photo detector identifier associated with a wavelength band identifier of a wavelength band according to a measurement item of a sample. The calculation unit calculates an absorbance related to the measurement item based on a signal from the selected specific photo detector.

公开(公告)号：US20170115260A1

公开(公告)日：2017-04-27

申请号：US15042091

申请日：2016-02-11

Applicant: JIADE YU

Inventor： JIADE YU

IPC: G01N30/78 ,  G01N21/64 ,  G01N21/33 ,  G01N30/74

CPC classification number: G01N30/78 ,  G01N21/33 ,  G01N21/645 ,  G01N30/74 ,  G01N2021/6417 ,  G01N2030/027 ,  G01N2201/068 ,  G01N2201/124

Abstract: The present invention relates to an innovative analyzing and detecting instrument with excellent sensitivity and stability, especially to a present art that realizes the initiation of the dual-purpose instrument in a small inner-casing which combines both ultraviolet-visible and double monochromatic fluorescence dual detector widely used in the high performance liquid chromatography by taking the first to use deuterium lamp as the individual light source of the dual detectors, the individual sample detection cell and the individual electrical circuit, providing two detectors for detecting and analyzing, and emphasizing the advanced automatic gain art adopted in the present invention to make sure the main technical targets of the whole wavelength range are integral, easy to be checked up, and can solve the existing worldwide technical problem of sensitivity-stability exclusion of the two detectors only with the combination of the double techniques in both automatically eliminating noise and reducing drift, so that the excellent technical performance can be achieved.

公开(公告)号：US20170115235A1

公开(公告)日：2017-04-27

申请号：US15317360

申请日：2015-06-22

Applicant: FlatFrog Laboratories AB

Inventor： NICKLAS OHLSSON ,  TOMAS CHRISTIANSSON

IPC: G01N21/958 ,  G01N21/94 ,  G01N21/59

CPC classification number: G01N21/958 ,  G01N21/59 ,  G01N21/94 ,  G01N2021/945 ,  G01N2201/124 ,  G06F3/0418 ,  G06F3/0421 ,  G06F2203/04109

Abstract: A device implements a method for detecting contamination of an FTIR-based panel. The apparatus generates projection signals representing detection lines that have propagated on a plurality of propagation paths by total internal reflection (TIR) inside a transmissive panel such that contamination on the panel surface causes attenuation (frustration) of at least one of the projection signals. The device generates a transmission value for each detection line in the transmissive panel, and determines the presence of contamination on the surface of the panel by comparing the transmission values according to at least one of the presented comparison techniques.

公开(公告)号：US09562851B2

公开(公告)日：2017-02-07

申请号：US14648874

申请日：2013-12-04

Applicant: SP3H

Inventor： Sylvain Oberti ,  Johan Fournel

IPC: G01N21/3577 ,  G01N21/3504 ,  G01N21/27 ,  G01N21/31

CPC classification number: G01N21/3577 ,  G01N21/274 ,  G01N21/3504 ,  G01N2021/3181 ,  G01N2201/062 ,  G01N2201/0624 ,  G01N2201/121 ,  G01N2201/1211 ,  G01N2201/124 ,  G01N2201/1242 ,  G01N2201/1247 ,  G01N2201/127 ,  G01N2201/12723

Abstract: The present invention relates to a method for controlling a spectrometer for analyzing a product, the spectrometer including a light source including several light-emitting diodes having respective emission spectra covering in combination an analysis wavelength band, the method including steps of: supplying at least one of the light-emitting diodes with a supply current to switch it on, measuring a light intensity emitted by the light source by measuring a current at a terminal of at least another of the light-emitting diodes maintained off, determining, according to each light intensity measurement, a setpoint value of the supply current of each diode that is on, and regulating the supply current of each diode that is on so that it corresponds to the setpoint value.

Abstract translation: 本发明涉及一种用于分析产品的光谱仪的控制方法，该光谱仪包括具有多个发光二极管的光源，该发光二极管具有组合分析波长带的各发射光谱，该方法包括以下步骤：将至少一个 的发光二极管与供电电流接通，通过测量至少另一个发光二极管的端子上的电流来测量由光源发射的光强度，根据每个光 强度测量，导通的每个二极管的电源电流的设定值，以及调节导通的每个二极管的电源电流，使其对应于设定值。

公开(公告)号：US20100192523A1

公开(公告)日：2010-08-05

申请号：US12668350

申请日：2008-07-07

Applicant: Peter Stoeckel ,  Frank Biedenbender ,  Thomas Kruger

Inventor： Peter Stoeckel ,  Frank Biedenbender ,  Thomas Kruger

IPC: G01N21/95 ,  B65B1/48 ,  G06K9/00 ,  H04N5/335

CPC classification number: G01N21/9508 ,  A61J3/074 ,  B07C5/3425 ,  G01F17/00 ,  G01N15/1463 ,  G01N21/274 ,  G01N2015/0096 ,  G01N2015/1497 ,  G01N2201/0694 ,  G01N2201/124 ,  G01N2201/12753 ,  G06T7/0006 ,  G06T2207/10024

Abstract: The present invention relates to a method for monitoring the filling of a capsule with a medicament, to a corresponding filling method, to the associated apparatuses, and to a computer program for controlling the method and the apparatus. In the monitoring method, after at least part of the capsule has been filled with a predefined filling mass of a predefined closed contour of the medicament, at least the filling mass in the part of the capsule after the filling operation is recorded using digital imaging in a first step, the contour of the filling mass in the part of the capsule is determined from the digital imaging recording in a second step, and the contour is analysed in a third step in order to assess the filling operation in comparison with the predefined contour. The invention provides for external influences on the image properties to be compensated for by controlling the optical system.

Abstract translation: 本发明涉及一种用于通过药物，相应的填充方法，相关装置以及用于控制该方法和装置的计算机程序来监测胶囊的填充的方法。 在监测方法中，在胶囊的至少一部分已经填充有药物的预定义的闭合轮廓的预定填充物质之后，至少填充操作之后的胶囊部分中的填充质量使用数字成像记录在 第一步骤，在第二步骤中从数字成像记录确定胶囊部分中的填充质量的轮廓，并且在第三步骤中分析轮廓，以便与预定轮廓相比较，评估填充操作 。 本发明通过控制光学系统来提供对补偿图像特性的外部影响。

公开(公告)号：US20070285655A1

公开(公告)日：2007-12-13

申请号：US11740767

申请日：2007-04-26

Applicant: Jan Lipson ,  Albert L. Lipson ,  Robert P. McNamara

Inventor： Jan Lipson ,  Albert L. Lipson ,  Robert P. McNamara

IPC: G01J3/00

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0289 ,  G01N21/4738 ,  G01N2021/4709 ,  G01N2021/4747 ,  G01N2021/656 ,  G01N2201/124

Abstract: An apparatus for enhancing the selectivity for spectroscopic measurements of analytes in a turbid medium is described. In one example, spatial filters are used to select only certain radii from the medium to be imaged. This selection is accomplished by placing an optical obstruction on the surface of the medium or at an image plane of the surface later in the optical imaging system. In one implementation, this is achieved by placing a fiber bundle at an image plane of the collecting optical system and then using a spacer of appropriate size at the center of the fiber bundle to act as a central obstruction.

Abstract translation: 描述了用于提高浑浊介质中分析物的光谱测量的选择性的装置。 在一个示例中，空间滤波器用于仅从要成像的介质中选择某些半径。 该选择通过在光学成像系统中稍后将光学障碍物放置在介质的表面或表面的像平面上来实现。 在一个实施方案中，这是通过将纤维束放置在收集光学系统的像平面上，然后在纤维束的中心使用适当尺寸的间隔件来充当中心障碍物来实现的。

公开(公告)号：US4673812A

公开(公告)日：1987-06-16

申请号：US740056

申请日：1985-05-30

Applicant: Aritoshi Yoneda

Inventor： Aritoshi Yoneda

IPC: G01N21/27 ,  G01N21/31 ,  G01N21/35 ,  G01N21/3504 ,  G01D18/00 ,  G01N21/61

CPC classification number: G01N21/314 ,  G01N21/274 ,  G01N21/3504 ,  G01N2201/124

Abstract: An amplifying circuit for amplifying an output from a measurement wavelength detector consists of a preamplifier and a measurement signal amplifier provided at an output of said preamplifier. The measurement signal amplifier is provided with an input-resistance and a feed-back resistance, a variable resistance connected in series to a normally open switch, the series combination being connected in parallel to the feed-back resistance so that the gain of the measurement signal amplifier may be variable.

Abstract translation: 用于放大来自测量波长检测器的输出的放大电路由前置放大器和设置在所述前置放大器输出端的测量信号放大器组成。 测量信号放大器具有输入电阻和反馈电阻，与常开开关串联的可变电阻，串联组合与反馈电阻并联连接，使得测量的增益 信号放大器可能是可变的。