Abstract:
This invention relates to an apparatus, method and system for directly obtaining the optical density of a dynamic biological system over the wide operating range and a wide range of organism mass, compensating for the primary interference factor, agitation and gas bubble formation, and thereby obtaining a on-line real time monitoring of cell density to follow the product concentration and progress of the biological reaction system.
Abstract:
Disclosed herein is a method for improving the precision of a test result from an instrument with an optical system that detects a signal. The method comprises including in the instrument a normalization target disposed directly or indirectly in the optical path of the optical system. Also disclosed are instruments comprising a normalization target, and systems comprising such an instrument and a test device that receives a sample suspected of containing an analyte.
Abstract:
A method of achieving instrument independent measurements for quantitative analysis of fiber-optic Raman spectroscope system, the system comprising a laser source, a spectroscope and a fiber optic probe to transmit light from the laser source to a target and return scattered light to the spectroscope, the method comprising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe-system transfer function, and storing the transfer function. Further provided is a method of performing real-time diagnostic Raman spectroscopy optionally in combination with the other disclosed methods.
Abstract:
An article is presented configured for controlling a multiple patterning process, such as a spacer self-aligned multiple patterning, to produce a target pattern. The article comprises a test site carrying a test structure comprising at least one pair of gratings, wherein first and second gratings of the pair are in the form of first and second patterns of alternating features and spaces and differ from the target pattern by respectively different first and second values which are selected to provide together a total difference such that a differential optical response from the test structure is indicative of a pitch walking effect.
Abstract:
A method of achieving instrument independent measurements for quantitative analysis of fiber-optic Raman spectroscope system, the system comprising a laser source, a spectroscope and a fiber optic probe to transmit light from the laser source to a target and return scattered light to the spectroscope, the method comprising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe-system transfer function, and storing the transfer function. Further provided is a method of performing real-time diagnostic Raman spectroscopy optionally in combination with the other disclosed methods.
Abstract:
The invention relates to an actuation and evaluation circuit for a laser diode (1) and a photodiode (3) for determining the concentration of a gas. The laser diode can generate light in the range of an absorption line of the gas. The circuit comprises a driver (10, 11, 12, 13) for generating a driving signal (17) for the laser diode (1), an assembly (8, 9) for generating a reference signal (20), and a subtractor (5) for subtracting the reference signal (20) from the signal (21) supplied by the photodiode. The invention further relates to a measuring device for determining the concentration of a gas by means of such an actuation and evaluation circuit. Finally, the invention relates to a corresponding method.
Abstract:
An apparatus and method for measuring the gloss of a surface with a light source projecting light in the direction of the surface and a light-sensitive sensor receiving the light reflected from the surface and converting it into an electrical signal value. A memory storing a program for calculating the characteristic gloss value, a computer for calculating a characteristic gloss value from the electrical signal value, and a display for visually displaying the calculated characteristic gloss value are provided. Five or more reference value pairs are stored in the memory, each pair consisting of a reference characteristic gloss value and a corresponding reference electrical signal value measured by the apparatus on the basis of the reference surface. The measured electrical signal value is compared with the reference signal values and at least the next higher and the next lower value for interpolating the measured gloss.
Abstract:
Some cyclic variables include within each cycle a value that can be determined extrinsically. In such case, the sensed value may differ from the known value by an amount that is a combination of long-term drift of the sensor and random measuring error. The drift component can be evaluated and eliminated by the following method. Once each cycle, for a number of cycles, the sensor measures the variable at a time when its value should equal the extrinsically-known value. The differences are plotted versus time, and a best-fitting straight line is determined, which indicates the drift. Throughout the next cycle as the variable is continuously sensed, the drift determined from the best-fitting straight line is continuously applied to correct the sensed value.
Abstract:
A method assures the quantitative or semiquantitative assessment of analytes in soils by in situ optical methods. A determination is made of the optical chemical response factors for chemicals of interest which are added in known amounts to discrete soil matrices (types) and conditions (moisture content) under controlled laboratory conditions to provide predetermined reference signals. A combination probe is provided with an optical chemical sensing device that produces chemical concentration signals representative of the concentration of a chemical of interest in a soil sample and further is provided with a strain gauge sensing device that produces strain gauge signals representative of soil type and optionally, condition of the soil sample. The combination probe is inserted into the soil sample and the optical chemical sensing device produces the chemical concentration signals and the optical strain gauge sensing device, simultaneously and in parallel, produces the optical strain gauge signals. The optical chemical concentration signals and strain gauge signals are fed to a processor where they are compared to the predetermined reference signals to arrive at an in situ quantification of chemicals of interest in the soil sample.
Abstract:
Color changes in a target, such as a chemical sensor using a colorchanging indicator reagent to detect the presence of a poisonous gas, are continuously monitored by reflecting the target (10) on to a sensor (16) light originating from first one and then another light source (12a, 12b, etc), each having a different, known emission wavelength. In each cycle, direct light from the appropriate source is also collected by another sensor (14), connected in a closed loop (26) with circuitry in which the emission intensity is compared with a known reference value (38) and which adjusts the emission intensity so as to stabilize it at this constant reference value. Once this is stabilized, the reflected light intensity signal is passed to a data store (20), after which a divider (22) produces an output signal (36) representing the ratio of the reflected light intensities in two separate cycles originating from two different light sources (12a, 12b, etc). The conduct of each cycle is controlled by timing means (18). Where there are two light sources, the wavelength of the second (12b) is outside the response range of the target, that of the first (12a) being at or near the peak target response, so that all the divider output signals represent successive values of actual reflected light intensity. These signals can be processed to show the rate of color change in the target and used to operate e.g. an alarm.