公开(公告)号：US08081305B2

公开(公告)日：2011-12-20

申请号：US12414111

申请日：2009-03-30

Applicant: Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang ,  Stephen McLaughlin

Inventor： Masud Azimi ,  Arran Bibby ,  Christopher D. Brown ,  Peili Chen ,  Kevin J. Knopp ,  Daryoosh Vakhshoori ,  Peidong Wang ,  Stephen McLaughlin

IPC: G01N21/35 ,  G01N21/65

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/4535 ,  G01N21/552

Abstract: We disclose an apparatus comprising: a hand-portable optical analysis unit including an optical interface; and a device configured to receive and releasably engage the hand-portable optical analysis unit. The device comprises: a housing; a sample unit in the housing; and a resilient member configured to bias the sample unit and the hand-portable analysis unit towards each other when the hand-portable optical analysis unit is received in the device to compress a sample disposed between the sample unit and the optical interface of the optical analysis unit. Methods of analyzing samples are also disclosed.

Abstract translation: 我们公开了一种装置，包括：手持式光学分析单元，包括光学接口; 以及被配置为接收和可释放地接合手持式光学分析单元的设备。 该装置包括：壳体; 壳体中的样品单元; 以及弹性构件，其构造成当所述手持式光学分析单元被接收在所述装置中时，将所述样本单元和所述手持式分析单元朝向彼此偏置，以压缩设置在所述样本单元和所述光学分析的所述光学界面之间的样本 单元。 还公开了分析样品的方法。

公开(公告)号：US08078268B2

公开(公告)日：2011-12-13

申请号：US12565279

申请日：2009-09-23

Applicant: John S. Maier ,  Shona Stewart ,  Jeffrey Cohen ,  Matthew Nelson ,  Patrick J Treado

Inventor： John S. Maier ,  Shona Stewart ,  Jeffrey Cohen ,  Matthew Nelson ,  Patrick J Treado

IPC: A61B6/00

CPC classification number: A61B5/0075 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/4064 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/6484 ,  G01N2201/08

Abstract: System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.

Abstract translation: 使用脉冲激光激发和时间门控检测来区分生物样品中组织边缘的系统和方法。 用基本单色的脉冲激光照射含有生物组织的区域，从而产生拉曼散射的光子。 使用时间门控检测来检测拉曼散射的光子，从而从包含生物体组织的区域的肿瘤部位或非肿瘤部位的特征的照射区域获得拉曼光谱图像。 肿瘤部位和非肿瘤部位之间的边界被区分，并且显示拉曼光谱图像中的边界位置。

公开(公告)号：US20110299077A1

公开(公告)日：2011-12-08

申请号：US13208774

申请日：2011-08-12

Applicant: Katsumi SHIBAYAMA ,  Tomofumi Suzuki ,  Masaki Hirose

Inventor： Katsumi SHIBAYAMA ,  Tomofumi Suzuki ,  Masaki Hirose

IPC: G01J3/02

CPC classification number: G01J3/2803 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0243 ,  G01J3/0259 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/18

Abstract: In a spectroscopy module 1, a light passing hole 50 through which a light L1 advancing to a spectroscopic portion 4 passes is formed in a light detecting element 5. Therefore, it is possible to prevent the relative positional relationship between the light passing hole 50 and a light detecting portion 5a of the light detecting element 5 from deviating. Moreover, the light detecting element 5 is bonded to a front plane 2a of a substrate 2 with an optical resin adhesive 63. Thus, it is possible to reduce a stress generated onto the light detecting element 5 due to a thermal expansion difference between the light detecting element 5 and the substrate 2. Additionally, on the light detecting element 5, a first convex portion 101 is formed so as to be located at least between the light detecting portion 5a and the light passing hole 50 when viewed from a direction substantially perpendicular to the front plane 2a. Thus, when the light detecting element 5 is attached to the substrate 2 via the optical resin adhesive 63, the optical resin adhesive 63 is dammed at the first convex portion 101. Thus, the optical resin adhesive 63 is prevented from penetrating into the light passing hole 50.

Abstract translation: 在光谱模块1中，在光检测元件5中形成有通过向分光部4前进的光L1通过的光通过孔50.因此，能够防止光通过孔50与 光检测元件5的光检测部分5a偏离。 此外，光检测元件5利用光学树脂粘合剂63接合到基板2的前面2a。因此，可以减少由于光的热膨胀差而在光检测元件5上产生的应力 检测元件5和基板2.此外，在光检测元件5上，当从基本上垂直的方向观察时，形成至少位于光检测部分5a和光通过孔50之间的第一凸部101 到前平面2a。 因此，当光检测元件5经由光学树脂粘合剂63安装到基板2上时，光学树脂粘合剂63被阻挡在第一凸部101处。因此，防止光学树脂粘合剂63渗透到光通过 孔50。

公开(公告)号：US20110299075A1

公开(公告)日：2011-12-08

申请号：US12896604

申请日：2010-10-01

Applicant: Jeffrey T. MEADE ,  Arsen R. HAJIAN ,  Bradford B. BEHR ,  Andrew T. CENKO

Inventor： Jeffrey T. MEADE ,  Arsen R. HAJIAN ,  Bradford B. BEHR ,  Andrew T. CENKO

IPC: G01J3/28 ,  G02B27/14 ,  G02B27/10

CPC classification number: G02B27/10 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0205 ,  G01J3/021 ,  G02B27/0927 ,  G02B27/0955

Abstract: An optical slicer for generating an output spot comprising an image compressor which receives a substantially collimated input beam and compresses the beam, wherein the input beam, if passed through a focusing lens, produces an input spot; an image reformatter which receives the compressed beam to reformat the beam into a plurality of sliced portions of the compressed beam and vertically stacks the portions substantially parallel to each other; and an image expander which expands the reformatted beam to produce a collimated output beam which, if passed through the focusing lens, produces the output spot that is expanded in a first dimension and compressed in a second dimension relative to the input spot.

Abstract translation: 一种用于产生输出光点的光学限幅器，包括接收基本上准直的输入光束并压缩光束的图像压缩器，其中如果输入光束通过聚焦透镜，则产生输入光斑; 接收压缩光束以将光束重新格式化成压缩光束的多个切片部分并垂直堆叠基本上彼此平行的部分的图像重新格式化器; 以及图像扩展器，其扩展重新格式化的光束以产生准直的输出光束，如果通过聚焦透镜产生在第一维度上扩展并相对于输入光点在第二维度中被压缩的输出光点。

公开(公告)号：US08071945B2

公开(公告)日：2011-12-06

申请号：US12184491

申请日：2008-08-01

Applicant: Sanjay Krishna ,  Majeed M. Hayat ,  J. Scott Tyo ,  Woo-Yong Jang

Inventor： Sanjay Krishna ,  Majeed M. Hayat ,  J. Scott Tyo ,  Woo-Yong Jang

IPC: G01J5/20

CPC classification number: H04N5/33 ,  G01J3/02 ,  G01J3/0259 ,  G01J3/32 ,  G01J3/46 ,  G01J3/465 ,  G01J3/50 ,  G01J2005/0077 ,  H01L27/14649 ,  H01L31/0352

Abstract: Exemplary embodiments provide an infrared (IR) retinal system and method for making and using the IR retinal system. The IR retinal system can include adaptive sensor elements, whose properties including, e.g., spectral response, signal-to-noise ratio, polarization, or amplitude can be tailored at pixel level by changing the applied bias voltage across the detector. “Color” imagery can be obtained from the IR retinal system by using a single focal plane array. The IR sensor elements can be spectrally, spatially and temporally adaptive using quantum-confined transitions in nanoscale quantum dots. The IR sensor elements can be used as building blocks of an infrared retina, similar to cones of human retina, and can be designed to work in the long-wave infrared portion of the electromagnetic spectrum ranging from about 8 μm to about 12 μm as well as the mid-wave portion ranging from about 3 μm to about 5 μm.

Abstract translation: 示例性实施方案提供用于制备和使用IR视网膜系统的红外（IR）视网膜系统和方法。 IR视网膜系统可以包括自适应传感器元件，其特性包括例如光谱响应，信噪比，偏振或幅度可以通过改变跨越检测器的所施加的偏置电压来在像素级别进行调整。 可以通过使用单个焦平面阵列从IR视网膜系统获得“彩色”图像。 IR传感器元件可以在纳米尺度量子点中使用量子限制过渡进行光谱，空间和时间适应。 IR传感器元件可以用作红外视网膜的结构单元，类似于人视网膜的锥体，并且可以设计成在约8μm至约12μm范围内的电磁光谱的长波红外部分中工作 作为约3μm至约5μm的中波部分。

公开(公告)号：US20110292386A1

公开(公告)日：2011-12-01

申请号：US13112316

申请日：2011-05-20

Applicant: Tatsuaki FUNAMOTO

Inventor： Tatsuaki FUNAMOTO

IPC: G01J3/42

CPC classification number: G01J3/51 ,  G01J3/02 ,  G01J3/0235 ,  G01J3/26 ,  G01J3/28 ,  G01J3/32 ,  G01J3/513 ,  G01J3/524

Abstract: A spectral measurement device includes an optical band-pass filter section having a spectral band of first to n-th wavelengths (n is an integer of 2 or more), a light receiving section, a correction operation section, and a signal processing section. When an m-th wavelength band (1≦m≦n) is an interest wavelength band, and a k-th wavelength band (k≠m and 1≦k≦n) other than the m-th wavelength band is a non-interest wavelength band, the optical band-pass filter section functions as a m-th band-pass filter corresponding to the m-th wavelength band and a k-th band-pass filter corresponding to the k-th wavelength band.

Abstract translation: 光谱测量装置包括具有第一至第n波长（n为2以上的整数）的光谱带的光学带通滤波器部，光接收部，校正操作部和信号处理部。 当第m个波长带（1＆nlE; m＆nlE; n）是兴趣波长带，并且第m波长带以外的第k波长带（k≠m和1＆nlE; k＆nlE; n） 光带通滤波器部分作为与第m波段相对应的第m个带通滤波器和与第k个波段相对应的第k个带通滤波器起作用。

公开(公告)号：US20110282167A1

公开(公告)日：2011-11-17

申请号：US13145927

申请日：2010-01-23

Applicant: Trent Ridder ,  Ben Ver Steeg ,  Mike Mills ,  Bentley Laaksonen

Inventor： Trent Ridder ,  Ben Ver Steeg ,  Mike Mills ,  Bentley Laaksonen

IPC: A61B5/1455

CPC classification number: A61B5/4845 ,  A61B5/0075 ,  A61B5/0088 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6826 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0291 ,  G01J3/14 ,  G01J2003/1286 ,  G01N21/274 ,  G01N21/359 ,  G01N21/474 ,  G01N2201/129

Abstract: An apparatus and method for non-invasive determination of attributes of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal- to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems include an illumination/modulation subsystem, a tissue sampling subsystem, a calibration maintenance subsystem, an FTIR spectrometer subsystem, a data acquisition subsystem, and a computing subsystem.

Abstract translation: 一种用于通过定量红外光谱法非侵入性地确定人体组织属性的装置和方法，其临床相关的精度和准确性水平。 该系统包括针对组织谱的复杂性，高信噪比和光度精度要求进行优化的子系统，组织抽样误差，校准维护问题和校准传递问题。 子系统包括照明/调制子系统，组织采样子系统，校准维护子系统，FTIR光谱仪子系统，数据采集子系统和计算子系统。

公开(公告)号：US20110278472A1

公开(公告)日：2011-11-17

申请号：US13166595

申请日：2011-06-22

Applicant: Josef Atzler

Inventor： Josef Atzler

IPC: G01N21/64

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/645 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with a cartridge support in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed. The cartridge support includes a plurality of cartridge positions that receive cartridges concurrently. One of the cartridges is a wavelength-tunable cartridge in which different light sources, excitation filters, and/or emission filters may be selected. Tuning is further accomplished by tilting the excitation or emission filters at desired angles relative to a beam of exciting light or emitted light.

Abstract translation: 提供了用于分析样品的装置中的盒和盒系统。 该系统具有用于多模仪器的不同应用的多个盒。 盒以“插入”格式可拆卸地与盒支撑接合，使得一个盒可以从装置移除，另一个盒可以容易地安装。 盒支架包括同时接收盒的多个盒位置。 其中一个墨盒是波长可调的墨盒，其中可以选择不同的光源，激发滤光片和/或发射滤光片。 通过将激发或发射滤光片相对于激发光束或发射光以期望的角度倾斜来进一步完成调谐。

公开(公告)号：US08059273B2

公开(公告)日：2011-11-15

申请号：US12496788

申请日：2009-07-02

Applicant: Yeonjoon Park ,  Sang H. Choi ,  Glen C. King ,  James R. Elliott

Inventor： Yeonjoon Park ,  Sang H. Choi ,  Glen C. King ,  James R. Elliott

IPC: G01J3/28

CPC classification number: G01J3/18 ,  G01J3/02 ,  G01J3/0229 ,  G01J2003/1861 ,  G02F1/134309

Abstract: A spectrometer system includes an optical assembly for collimating light, a micro-ring grating assembly having a plurality of coaxially-aligned ring gratings, an aperture device defining an aperture circumscribing a target focal point, and a photon detector. An electro-optical layer of the grating assembly may be electrically connected to an energy supply to change the refractive index of the electro-optical layer. Alternately, the gratings may be electrically connected to the energy supply and energized, e.g., with alternating voltages, to change the refractive index. A data recorder may record the predetermined spectral characteristic. A method of detecting a spectral characteristic of a predetermined wavelength of source light includes generating collimated light using an optical assembly, directing the collimated light onto the micro-ring grating assembly, and selectively energizing the micro-ring grating assembly to diffract the predetermined wavelength onto the target focal point, and detecting the spectral characteristic using a photon detector.

Abstract translation: 光谱仪系统包括用于准直光的光学组件，具有多个同轴对准的环形光栅的微环格栅组件，限定限定目标焦点的孔的孔装置和光子检测器。 光栅组件的电光层可电连接到能量源以改变电光层的折射率。 或者，光栅可以电连接到能量供应并且例如用交流电压通电，以改变折射率。 数据记录器可以记录预定的光谱特性。 检测源光的预定波长的光谱特性的方法包括使用光学组件产生准直光，将准直光引导到微环格栅组件上，以及选择性地激励微环格栅组件以将预定波长衍射到 目标焦点，并使用光子检测器检测光谱特性。

公开(公告)号：US20110273558A1

公开(公告)日：2011-11-10

申请号：US13143897

申请日：2010-01-11

Applicant: Jeyamkondan Subbiah ,  Chris Richard Calkins ,  Ashok Kumor Samal ,  Govindarajan Konda Naganathan

Inventor： Jeyamkondan Subbiah ,  Chris Richard Calkins ,  Ashok Kumor Samal ,  Govindarajan Konda Naganathan

IPC: H04N9/47

CPC classification number: G01N33/12 ,  G01J3/02 ,  G01J3/0262 ,  G01J3/0291 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/42 ,  G01N21/3563 ,  G06T7/0004 ,  G06T2207/10024 ,  G06T2207/30128

Abstract: A system and method for obtaining multispectral images of fresh meat at predetermined wavelength bands at a first time, subjecting the images to analysis in an image analysis system comprising a computer programmed to perform such analysis, and outputting a forecast of meat tenderness at a later point in time. Predetermined key wavelength bands are precorrelated with a high degree of prediction of meat tenderness and/or other properties of meat and are used in the multispectral system and method. A system and method for determining the key wavelengths is also disclosed. The multispectral imaging system and method is suitable for use in an industrial setting, such as a meat processing plant. The system and method is useful in a method for determining quality and yield grades at or near the time of imaging in lieu of visual inspection with the unaided human eye, increasing efficiency and objectivity.

Abstract translation: 一种用于在第一时间获得预定波段的新鲜肉的多光谱图像的系统和方法，对图像进行分析，所述图像分析系统包括被编程为执行该分析的计算机的图像分析系统，并且稍后输出肉嫩的预测 及时。 预先确定的关键波长带与肉类压痛和/或其他肉类的高度预测相关，并且用于多光谱系统和方法。 还公开了一种用于确定关键波长的系统和方法。 多光谱成像系统和方法适用于工业设备，如肉类加工厂。 该系统和方法可用于在成像时间或接近成像时确定质量和产量等级的方法，代替用肉眼观察目视检查，提高效率和客观性。