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    HIGH FLOWRATE FLUSHING FOR OPEN PORT SAMPLING PROBE
    42.
    发明公开
    HIGH FLOWRATE FLUSHING FOR OPEN PORT SAMPLING PROBE 审中-公开

    公开(公告)号：US20230197428A1

    公开(公告)日：2023-06-22

    申请号：US17999614

    申请日：2021-05-20

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Thomas R. COVEY ,  Chang LIU

    IPC: H01J49/04 ,  H01J49/24

    CPC classification number: H01J49/0404 ,  H01J49/24 ,  H01J49/044

    Abstract: In a sampling system for mass spectrometry, a method and apparatus are set forth for high flow-rate flushing and sample delivery via a sampling probe (10). The sampling system includes a sampling probe (10) having a first fluid conduit (40) with an inlet, a second fluid conduit (42) with an outlet, and a sampling port fluidly connecting the first fluid conduit (40) and second fluid conduit (42). A fluid source (50) is attached to the inlet and a vacuum source (60) is attached to the outlet for causing fluid to flow through the first fluid conduit (40) past the sampling port and exit through the second fluid conduit (42). A cap (90) is provided for selectively closing and opening the sampling port. When the cap is removed, thus when the sampling port is open, sample may be introduced into, and captured by fluid flowing through the sampling port. When the cap is in place, thus when the sampling port is closed, a flushing fluid is supplied for flushing the sampling probe (10).

    Ion Source for Mass Spectrometry
    46.
    发明申请
    Ion Source for Mass Spectrometry 有权
    质谱离子源

    公开(公告)号：US20170032949A1

    公开(公告)日：2017-02-02

    申请号：US15104638

    申请日：2014-10-31

    Applicant: DH Technologies Development PTE Ltd.

    Inventor： Thomas R Covey ,  Peter Kovarik

    IPC: H01J49/04 ,  G01N30/72

    CPC classification number: H01J49/045 ,  G01N30/724 ,  G01N30/7246 ,  G01N30/7273 ,  H01J49/0404 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/167

    Abstract: Systems and methods for delivering a sample to a mass spectrometer are provided. In one aspect, the systems and methods can provide efficient cooling of an ion source probe to prevent overheating and the resulting degradation in ion sampling. In some aspects, such cooling can result in improved consistency and/or efficiency of ion formation. Moreover, ion source cooling in accordance with various aspects of the present teachings can allow for the use of higher temperatures in the ionization chamber (thereby improving desolvation) and/or can enable the use of lower flow rate sample sources than with conventional techniques.

    Abstract translation: 提供了将样品递送到质谱仪的系统和方法。 在一个方面，系统和方法可以提供离子源探针的有效冷却，以防止过热和离子取样导致的降解。 在一些方面，这种冷却可导致提高离子形成的一致性和/或效率。 此外，根据本教导的各个方面的离子源冷却可以允许在电离室中使用更高的温度（从而改善去溶剂化）和/或可以使用比常规技术更低的流速样品源。

    Off-axis channel in electrospray ionization for removal of particulate matter
    47.
    发明授权
    Off-axis channel in electrospray ionization for removal of particulate matter 有权
    用于去除颗粒物质的电喷雾离子离子通道

    公开(公告)号：US09230786B1

    公开(公告)日：2016-01-05

    申请号：US14301431

    申请日：2014-06-11

    Applicant: Bruker Daltonics, Inc.

    Inventor： David Kennedy ,  Kerry Nugent

    IPC: H01J49/10 ,  H01J49/04 ,  H01J49/16

    CPC classification number: H01J49/0404 ,  H01J49/044 ,  H01J49/165 ,  H01J49/167

    Abstract: The present invention relates to electrospray ionization (ESI) at atmospheric pressure coupled with a mass spectrometer, in particular to a special kind of micro-electrospray with liquid flows in the range of 0.1 to 100 microliters per minute. The invention describes the use of an off-axis pre-entrance channel in an ESI ion source to prevent particulate matter with higher inertia than the (charged) gas molecules, such as droplets, from entering the mass spectrometer. The elimination of the particulate matter improves the quantitative precision of an LC/MS bioassay, minimizes the contamination of the mass spectrometer and improves the robustness for high throughput assays.

    Abstract translation: 本发明涉及在大气压力下与质谱联用的电喷雾离子化（ESI），特别涉及一种特殊类型的微电喷雾，液体流速为0.1至100微升/分钟。 本发明描述了在ESI离子源中使用离轴预入口通道来防止比（带电）的气体分子（例如液滴）更高的惯性的颗粒物质进入质谱仪。 颗粒物的消除提高了LC / MS生物测定的定量精度，最大限度地降低了质谱仪的污染，并提高了高通量测定的鲁棒性。

    Ionization method and apparatus including applying converged shock waves to a spray
    48.
    发明授权
    Ionization method and apparatus including applying converged shock waves to a spray 有权
    电离方法和装置包括将融合的冲击波应用于喷雾

    公开(公告)号：US09103783B2

    公开(公告)日：2015-08-11

    申请号：US12933058

    申请日：2008-03-17

    Applicant: Shinichi Yamaguchi

    Inventor： Shinichi Yamaguchi

    IPC: H01J49/00 ,  G01N27/62 ,  H01J49/04 ,  H01J49/16

    CPC classification number: G01N27/62 ,  H01J49/044 ,  H01J49/165

    Abstract: A sample solution containing a sample component is sprayed onto an atmosphere at atmospheric approximately pressure while being applied with electric charge from the tip of a nozzle (1). A sample molecule is released as an ion in a process where charged minute liquid droplets collide with an atmospheric gas and are broken apart, and a solvent is vaporized from the respective liquid droplets. A reflectron (7) in the shape of a half-cut spheroid is arranged in such a manner that a second focal point (F2) is positioned in front of an ion-introducing portion (4) in the spray flow. A discharge electrode (8) is disposed in a position at a first focal point (F1) of the reflectron (7). When pulsed high voltage is applied to the discharge electrode (8), an electric discharge occurs, causing shock waves to be generated. The shock waves reflected on the reflectron (7) are converged on the second focal point (F2). Due to the converged shock waves, the vicinity of the second focal point (F2) rises to a high temperature, and a large pressure is also applied thereto. Therefore, vaporization of a solvent from the respective liquid droplets is further accelerated, allowing an ion to be easily generated. In addition, direct ionization can be expected. This makes it possible to improve ion generation efficiency.

    Abstract translation: 将包含样品组分的样品溶液在大气压大气压下喷雾，同时从喷嘴（1）的尖端施加电荷。 在带电的微小液滴与大气气体碰撞并分离开的过程中，样品分子作为离子释放，并且溶剂从各个液滴中汽化。 以半切球体形状的反射镜（7）以这样的方式布置，使得第二焦点（F2）位于喷射流中的离子引入部分（4）的前面。 放电电极（8）设置在反射器（7）的第一焦点（F1）的位置。 当向放电电极（8）施加脉冲高电压时，发生放电，产生冲击波。 在反射镜（7）上反射的冲击波会聚在第二焦点（F2）上。 由于会聚的冲击波，第二焦点（F2）的附近上升到高温，也施加大的压力。 因此，来自各液滴的溶剂的蒸发进一步加速，容易产生离子。 此外，可以预期直接电离。 这使得可以提高离子产生效率。

    SYSTEM AND METHOD FOR APPLYING CURTAIN GAS FLOW IN A MASS SPECTROMETER
    49.
    发明申请
    SYSTEM AND METHOD FOR APPLYING CURTAIN GAS FLOW IN A MASS SPECTROMETER 有权
    用于在大量光谱仪中应用阴幕气体的系统和方法

    公开(公告)号：US20140319338A1

    公开(公告)日：2014-10-30

    申请号：US14359853

    申请日：2012-11-21

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Bruce A. Thomson ,  Mircea Guna

    IPC: H01J49/04 ,  H01J49/26

    CPC classification number: H01J49/0422 ,  H01J49/044 ,  H01J49/26

    Abstract: A system of mass spectrometry is disclosed having an ion source for generating ions at substantially atmospheric pressure. The system has a sampling member with an orifice disposed therein. The sampling member forms a vacuum chamber with a mass spectrometer. The system also has a curtain plate between the ion source and the sampling member. The curtain plate has an aperture therein, having a cross-section and being spaced from the sampling member to define a flow passage between the curtain plate and the sampling member, and to define an annular gap between the orifice and the aperture. The area of the annular gap is less than the cross-sectional area of the aperture. The system also has a power supply for applying a voltage to the curtain plate, and a curtain gas flow mechanism for directing a curtain gas into the flow passage and the annular gap.

    Abstract translation: 公开了一种质谱系统，其具有用于在基本上大气压下产生离子的离子源。 该系统具有设置在其中的孔口的取样构件。 采样构件形成具有质谱仪的真空室。 该系统还在离子源和采样构件之间具有帘板。 帘板在其中具有孔，其具有横截面并且与采样构件间隔开以限定在帘板和采样构件之间的流动通道，并且在孔和孔之间限定环形间隙。 环形间隙的面积小于孔的横截面面积。 该系统还具有用于向帘板施加电压的电源，以及用于将帘式气体引导到流动通道和环形间隙中的帘式气体流动机构。

    Method and system for providing a dual curtain gas to a mass spectrometry system
    50.
    发明授权
    Method and system for providing a dual curtain gas to a mass spectrometry system 有权
    用于向质谱系统提供双帘式气体的方法和系统

    公开(公告)号：US08779356B2

    公开(公告)日：2014-07-15

    申请号：US13821148

    申请日：2011-09-14

    Applicant: Thomas R. Covey ,  Stanislaw Potyrala ,  Bradley B. Schneider

    Inventor： Thomas R. Covey ,  Stanislaw Potyrala ,  Bradley B. Schneider

    IPC: H01J49/24 ,  B01D59/44

    CPC classification number: H01J49/02 ,  H01J49/044

    Abstract: A system and method for mass spectrometry including a curtain gas chamber defined by a curtain plate having an aperture for receiving ions from an ion source and an orifice plate having an inlet into a mass spectrometer. At least one barrier separates the curtain chamber into a first curtain gas chamber region and a second curtain gas chamber region. At least one gas source provides a gas inflow into the second curtain gas chamber region and a gas outflow into the first curtain gas chamber region, a portion of the gas outflow directed out of the aperture. A heating element heats the gas inflow, a portion of the heated gas inflow directed into the inlet of the mass spectrometer wherein the portion of the heated gas inflow can be at a substantially higher temperature than the portion of the gas outflow.

    Abstract translation: 一种用于质谱的系统和方法，包括由具有用于从离子源接收离子的孔的幕板限定的帘式气室和具有入口进入质谱仪的孔板。 至少一个屏障将幕帘室分隔成第一帘式气体室区域和第二帘式气体室区域。 至少一个气体源提供气体流入第二帘式气体室区域，并且气体流入第一帘式气体室区域，一部分气体流出物被引导出孔。 加热元件加热气体流入，一部分加热气体流入引导到质谱仪的入口，其中加热气体流入的部分可以处于比气体流出部分显着更高的温度。

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