公开(公告)号：US09874522B2

公开(公告)日：2018-01-23

申请号：US15128111

申请日：2015-03-23

Applicant: OPTIQGAIN LTD.

Inventor： Ram Alon ,  Dan Leigh ,  Nitzan Eliyahu ,  Yaron Lapidot

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/10

CPC classification number: G01N21/65 ,  G01J3/10 ,  G01J3/44 ,  G01J3/4412 ,  G01J2003/102 ,  G01N21/274 ,  G01N2021/655 ,  G01N2201/06113

Abstract: A small size, robust stimulated Raman scattering (SRS) spectrophotometer system for industrial, medical and field use, exhibiting high SNR, high resolution and very short acquisition times. The architecture of the system allowing for such features comprises three main elements: (1). Use of a narrow range tunable pump laser and an array of fixed wavelength lasers to produce the wavelength differences as required to generate the SRS (Raman) spectrum; (2). Application of analog signal processing, prior to the digital conversion, in order to obtain higher resolution and SNR; (3). Use of relatively inaccurate or unstable laser sources coupled to calibration samples, followed by various calibration methods to compensate for system instabilities, such as wavelength drift, laser inaccuracies, and variations in the optical components/elements of the system.

公开(公告)号：US09867544B2

公开(公告)日：2018-01-16

申请号：US14821933

申请日：2015-08-10

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Dongho Kim

IPC: A61B5/00 ,  H01L31/0304 ,  G01J3/51 ,  G01J3/02 ,  G01J3/10 ,  G01J3/32 ,  G01J3/42 ,  G01J3/44 ,  H01L31/103 ,  G01J3/12

CPC classification number: A61B5/0075 ,  G01J3/0205 ,  G01J3/0227 ,  G01J3/0256 ,  G01J3/0259 ,  G01J3/0272 ,  G01J3/10 ,  G01J3/32 ,  G01J3/42 ,  G01J3/44 ,  G01J3/4406 ,  G01J3/51 ,  G01J2003/1213 ,  G01J2003/1226 ,  H01L31/1035

Abstract: Provided are a spectrometer that may be easily manufactured while having high resolution and sensitivity due to reduced light loss and a non-invasive biometric sensor including the spectrometer. The spectrometer includes: a stacked light absorbing structure including a plurality of absorbing layers stacked in a vertical direction and having different absorption wavelength bands, and a plurality of tunnel junction layers respectively interposed between the plurality of absorbing layers to electrically connect the plurality of absorbing layers; and an illuminating unit configured to provide the stacked light absorbing structure with an illumination light for saturation of the plurality of absorbing layers.

公开(公告)号：US20170370772A1

公开(公告)日：2017-12-28

申请号：US15539282

申请日：2015-12-23

Applicant: UNIVERSITE BORDEAUX MONTAIGNE ,  UNIVERSITE DE BORDEAUX ,  INSTITUT POLYTECHNIQUE DE BORDEAUX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Aurelie MOUNIER ,  Floréal DANIEL ,  Sylvain LAZARE

IPC: G01J3/10 ,  G01J3/44 ,  G01N21/64

CPC classification number: G01J3/10 ,  G01J3/4406 ,  G01J2003/106 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/6417 ,  G01N2021/6419

Abstract: An LED spectrofluorometer (100) for analysis of an object (101) includes a light excitation element (11, 112, 113) suitable for illuminating a study zone (101B) of the object with an excitation light beam (1), and an optical routing element (121, 122, 123, 124) suitable for collecting a fluorescent light flux (2) emitted by the study zone excited by the excitation light beam and for routing the fluorescent light flux to an optical spectrometer (131) for analysis of the light spectrum thereof. The light excitation element includes a first light-emitting diode (111) and a second-light emitting diode (112), the first light-emitting diode emitting at a first wavelength (λ1) between 250 and 300 nm and the excitation light beam being formed from one or other of the light beams generated by each light-emitting diode.

公开(公告)号：US09851303B2

公开(公告)日：2017-12-26

申请号：US15316568

申请日：2015-06-03

Applicant: Ludwig-Maximilians-Universität München

Inventor： Robert Alexander Huber ,  Sebastian Karpf ,  Matthias Eibl

IPC: G01N21/64 ,  G01N21/65

CPC classification number: G01N21/6456 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/65 ,  G01N2021/6484 ,  G01N2201/06146 ,  G01N2201/0635 ,  G01N2201/105 ,  G01N2201/11 ,  G01N2201/12 ,  H01S3/06712 ,  H01S3/06754 ,  H01S3/094007 ,  H01S3/10015 ,  H01S3/1618 ,  H01S3/2316 ,  H01S3/302 ,  H01S2301/02

Abstract: Described is a system for inducing and detecting multi-photon processes, in particular multi-photon fluorescence or higher harmonic generation in a sample. The system comprises a dynamically-controllable light source, said dynamically-controllable light source comprising a first sub-light source, said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, and at least one optical amplifier, thereby allowing for active time-control of creation of multi-photon-excitation. The system further comprises a beam delivery unit for delivering light generated by said dynamically-controllable light source to a sample site, and a detector unit or detector assembly for detecting signals indicative of said multi-photon process, in particular multi-photon fluorescence signals or higher harmonics signals.

公开(公告)号：US09841321B2

公开(公告)日：2017-12-12

申请号：US15406968

申请日：2017-01-16

Applicant: Thermo Scientific Portable Analytical Instruments Inc.

Inventor： Timothy M. Pastore ,  David Perez ,  Michael D. Hargreaves

IPC: G01J3/12 ,  G01J3/02 ,  G01J3/42 ,  G01J3/44 ,  G01N21/552 ,  G01J3/28 ,  G01J3/10 ,  G01N21/65 ,  G01N21/71 ,  G01N21/35 ,  G01N21/39 ,  G01N21/359

CPC classification number: G01J3/0264 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/10 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/42 ,  G01J3/44 ,  G01N21/359 ,  G01N21/552 ,  G01N21/65 ,  G01N21/718 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/0221

Abstract: A hand-held spectrometer includes at least one indicator light and a processor configured to control the at least one indicator light to indicate a state of the hand-held spectrometer selected from a group consisting of a background scanning state, a ready-to-scan-sample state, a signal strength state, a fluorescence intensity state, a sample match state, a sample classification state, an error state, a data transfer state, a battery charge state, and a memory capacity state. The sample match state can be, for example, one of a positive match state, a mixture match state, a negative match state, and a match error state. In some embodiments, the error state can be at least one of a background error state, a user error state, and an instrument error state, or any combination thereof.

公开(公告)号：US20170336255A1

公开(公告)日：2017-11-23

申请号：US15598152

申请日：2017-05-17

Applicant: University of Maribor

Inventor： Denis Donlagic ,  Simon Pevec

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/10 ,  G01J3/42 ,  G01J3/32 ,  G01J3/26 ,  G01L9/00 ,  G01J3/427

CPC classification number: G01J3/0218 ,  G01B2290/25 ,  G01J3/0208 ,  G01J3/0224 ,  G01J3/0237 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/42 ,  G01J3/427 ,  G01J2003/102 ,  G01J2003/104 ,  G01L9/0079

Abstract: An optical system having an optical sensor with an ultra-short FP cavity, and a low-resolution optical interrogation system coupled to the optical sensor and operational to send light signals and receive light signals to and from the optical sensor is disclosed. The optical system may operate in a wavelength range including the visible and near-infrared range. Optical assemblies and methods of interrogating optical sensors are provided, as are numerous other aspects.

公开(公告)号：US09823185B1

公开(公告)日：2017-11-21

申请号：US15644775

申请日：2017-07-08

Applicant: Airware, Inc.

Inventor： Jacob Y Wong ,  Thomas Campbell

IPC: G01N21/3504

CPC classification number: G01N21/3504 ,  G01J3/10 ,  G01J3/42 ,  G01J3/427 ,  G01N21/3151 ,  G01N21/3577 ,  G01N21/61 ,  G01N33/49 ,  G01N2021/3159 ,  G01N2201/0696

Abstract: For determining concentration of a targeted molecule M in a liquid sample admixed with interfering molecules MJ which overlap its absorption band, a NDIR reflection sampling technique is used. Besides the signal source, a reference and an interference source are added. M is calculated by electronics which use Rave(t) from a pulsed signal and reference channel output and a calibration curve which is validated by use of RJava(t2) from a pulsed interference and reference channel output. Signal, interference and reference sources are pulsed at a frequency which is sufficiently fast so that a given molecule of M or MJ will not pass in and out of the liquid sampling matrix within the pulsing frequency.

公开(公告)号：US09816932B2

公开(公告)日：2017-11-14

申请号：US15313420

申请日：2015-08-13

Applicant: CANON KABUSHIKI KAISHA

Inventor： Naoki Kohara

IPC: G01N21/25 ,  G01N21/65 ,  G02B21/00 ,  H01S3/13 ,  H01S3/23 ,  G02F1/35

CPC classification number: G01N21/65 ,  G01J3/10 ,  G01N2021/655 ,  G01N2201/06113 ,  G01N2201/0697 ,  G01N2201/105 ,  G02B21/0032 ,  G02B21/0076 ,  G02F1/3534 ,  H01S3/13 ,  H01S3/2391

Abstract: A pulsed light synchronizer synchronizes a first pulsed light having a first period and a second pulsed light and having a second period equal to the first period with each other. A third pulsed light is acquired by providing a first delay time between two pulsed lights acquired by dividing the first pulsed light, and by multiplexing the pulsed lights acquired from the first pulsed light. A fourth pulsed light is acquired by providing a second delay time between two pulsed lights acquired by dividing the second pulsed light, and by multiplexing the pulsed lights acquired from the second pulsed light. The pulsed light synchronizer detects, through a detector, a pulsed light acquired by multiplexing the third and fourth pulsed lights, and adjusts at least one of the first and second periods based on a timing difference between the third and fourth pulsed lights acquired from the detector.

公开(公告)号：US09804028B2

公开(公告)日：2017-10-31

申请号：US14616673

申请日：2015-02-07

Applicant: Spectral Sciences, Inc.

Inventor： Pajo Vukovic-Cvijin

IPC: H01S3/10 ,  G01J3/433 ,  G01J3/10 ,  H01S5/14 ,  H01S5/40 ,  G01J3/02 ,  G01J3/18 ,  H01S3/08 ,  H01S5/10 ,  H01S5/34 ,  H01S3/081 ,  H01S5/022 ,  G01J3/42

CPC classification number: G01J3/433 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/18 ,  G01J2003/423 ,  H01S3/08009 ,  H01S3/0816 ,  H01S5/02248 ,  H01S5/1092 ,  H01S5/141 ,  H01S5/3402 ,  H01S5/4062 ,  H01S5/4087

Abstract: A tunable laser source that includes multiple gain elements and uses a spatial light modulator in an external cavity to produce spectrally tunable output is claimed. Several designs of the external cavity are described, targeting different performance characteristics and different manufacturing costs for the device. Compared to existing devices, the tunable laser source produces high output power, wide tuning range, fast tuning rate, and high spectral resolution.

公开(公告)号：US09795303B2

公开(公告)日：2017-10-24

申请号：US14961647

申请日：2015-12-07

Applicant: Hypermed Imaging, Inc.

Inventor： Svetlana V. Panasyuk ,  Jenny Freeman ,  Alexander Panasyuk

IPC: A61B5/00 ,  G01J3/02 ,  G01J3/10 ,  G01J3/28 ,  G01N21/21 ,  G01N21/31 ,  A61B5/02 ,  G01N21/35 ,  G01N21/359

CPC classification number: A61B5/0091 ,  A61B5/0059 ,  A61B5/02007 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/4842 ,  A61B5/742 ,  A61B5/7425 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0264 ,  G01J3/10 ,  G01J3/2823 ,  G01N21/21 ,  G01N21/31 ,  G01N21/35 ,  G01N21/359 ,  G01N2021/3137 ,  G01N2021/3155 ,  G01N2021/317

Abstract: Apparatus and methods for hyperspectral imaging analysis that assists in real and near-real time assessment of biological tissue condition, viability, and type, and monitoring the above overtime. Embodiments of the invention are particularly useful in surgery, clinical procedures, tissue assessment, diagnostic procedures, health monitoring, and medical evaluations, especially in the detection and treatment of cancer.