公开(公告)号：US20170370928A1

公开(公告)日：2017-12-28

申请号：US15681647

申请日：2017-08-21

Applicant: Hycor Biomedical, LLC

Inventor： Ronald Norman Diamond ,  Steven Michael Gann ,  Eric Darnell Hall ,  Tae Ho Hwang ,  John Lewis Morton ,  Anatoly Moskalev ,  Bruce Alan Sargeant ,  Dennis Edwin Rieger ,  Marinela Gombosev ,  Mark David Van Cleve

IPC: G01N33/564 ,  G01N21/64 ,  G01N21/76 ,  G01N33/53 ,  G01N33/569 ,  G01N33/58 ,  G01N33/68 ,  G01N35/10 ,  G01N35/00 ,  G01N33/543 ,  G01N35/04

CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N21/76 ,  G01N33/5306 ,  G01N33/54326 ,  G01N33/5434 ,  G01N33/54393 ,  G01N33/564 ,  G01N33/569 ,  G01N33/5695 ,  G01N33/56983 ,  G01N33/582 ,  G01N33/6854 ,  G01N33/6893 ,  G01N35/0098 ,  G01N35/1011 ,  G01N2021/6484 ,  G01N2035/0453 ,  G01N2035/1062 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2333/4703 ,  G01N2333/62 ,  G01N2333/78 ,  G01N2800/24 ,  Y10T436/119163

Abstract: Apparatuses and methods of optically analyzing fluid within a pipette are described herein. In an embodiment, an optical reader subassembly includes a pipette configured to aspirate and hold a fluid sample within its tip, a housing configured to receive at least the tip of the pipette through a reentrant seal so that the tip of the pipette is located in a light tight manner within an internal area, a light source positioned to be in proximity to the tip of the pipette when the tip of the pipette is received by the housing, the light source configured to project light through the tip of the pipette and onto the fluid sample held within the tip, and an optical sensor configured to take a reading of the fluid sample held within the tip of the pipette without any of the fluid sample being injected from the pipette.

公开(公告)号：US20170367585A1

公开(公告)日：2017-12-28

申请号：US15686198

申请日：2017-08-25

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/10 ,  G01J3/28 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N33/49 ,  G01N33/44 ,  G01N33/15 ,  G01N33/02 ,  G01N21/88 ,  G01J3/453 ,  G01M3/38 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A wearable device for use with a smart phone or tablet includes LEDs for measuring physiological parameters by modulating the LEDs and generating a near-infrared multi-wavelength optical beam. At least one LED emits at a first wavelength having a first penetration depth and at least another LED emits at a second wavelength having a second penetration depth into tissue. The device includes lenses that deliver the optical beam to the tissue, which reflects the first and second wavelengths. A receiver is configured to capture light while the LEDs are off and while at least one of the LEDs is on and to difference corresponding signals to improve a signal-to-noise ratio of the optical beam reflected from the tissue. The signal-to-noise ratio is further increased by increasing light intensity of at least one of the LEDs. The device generates an output signal representing a non-invasive measurement on blood within the tissue.

公开(公告)号：US09846115B2

公开(公告)日：2017-12-19

申请号：US14917574

申请日：2013-09-09

Applicant: KOC UNIVERSITESI

Inventor： Hakan Urey ,  Goksenin Yaralioglu

IPC: B01L3/00 ,  G01N21/17 ,  G01N11/16 ,  G01N29/02 ,  G01N5/00 ,  G01N29/24

CPC classification number: G01N21/1702 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2300/06 ,  B01L2300/0654 ,  B01L2300/16 ,  B01L2300/18 ,  G01N5/00 ,  G01N11/16 ,  G01N29/022 ,  G01N29/2418 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/08 ,  G01N2291/012 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0427

Abstract: The present invention relates generally to the field of chemical and biological sensors and in particular to micro electro-mechanical systems (MEMS) sensors for measuring fluid viscosity and detection of minute amounts of chemicals and biological agents in fluids. It is an object of the present invention to provide a sensor that will work in disposable cartridges with remote sensing that can measure dynamic changes of the functionalized cantilevers in liquid and gas environment.

公开(公告)号：US20170328836A1

公开(公告)日：2017-11-16

申请号：US15418350

申请日：2017-01-27

Applicant: UVic Industry Partnerships Inc.

Inventor： Tao Lu

IPC: G01N21/65 ,  G02B6/032 ,  G02B6/255

CPC classification number: G01N21/658 ,  G01N21/65 ,  G01N2201/0612 ,  G01N2201/08 ,  G01N2201/0846 ,  G02B6/032 ,  G02B6/2551 ,  G02B6/2821 ,  G02B6/2856

Abstract: A system and a method for optical sensing of single molecule or molecules in various concentrations are provided. The optical sensor system comprises a first fiber, a second fiber, a light source and a detection device. The first fiber and the second fiber are fused together to form an optical coupler. The first fiber serves as the passageway for the analyte, while the second fiber serves as the waveguide for the light that will interact with the said analyte. One end of the second fiber is connected to the light source (e.g. laser), and the opposite end is connected to the detection device (e.g. spectrometer). The analyte is introduced into the first fiber through one of its ends, and is allowed to flow through inside the hollow core of the said first fiber. When light is delivered through the input end of the second fiber, the evanescent light is formed in the optical coupler and is allowed to interact with the analyte in the first fiber. One scenario in this analyte-light interaction results in, for example, the generation of Raman emission that is used as the probing signal. The spectrum of the Raman emission is analyzed by the detection device to determine the presence of target molecule.

公开(公告)号：US09804092B2

公开(公告)日：2017-10-31

申请号：US14766451

申请日：2014-02-11

Applicant: British Columbia Cancer Agency Branch

Inventor： Haishan Zeng ,  Michael Short ,  Jianhua Zhao

IPC: G01N21/65 ,  G01N21/64 ,  G01J3/44 ,  A61B5/00 ,  G01J3/02

CPC classification number: G01N21/65 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B2560/0285 ,  G01J3/0213 ,  G01J3/0221 ,  G01J3/4406 ,  G01N21/64 ,  G01N21/645 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/084

Abstract: Examples of a spectroscopy probe for performing measurements of Raman spectra, reflectance spectra and fluorescence spectra are disclosed. The integrated spectral probe can comprise one or more light sources to provide a white light illumination to generate reflectance spectra, an excitation light to generate an UV/visible fluorescence spectra and a narrow band NIR excitation to induce Raman spectra. The multiple modalities of spectral measurements can be performed within 2 seconds or less. Examples of methods of operating the integrated spectroscopy probe disclosed.

公开(公告)号：US09777321B2

公开(公告)日：2017-10-03

申请号：US15260773

申请日：2016-09-09

Applicant: Industrial Technology Research Institute

Inventor： Chung-Fan Chiou ,  Ying-Chih Pu ,  Chao-Chi Pan ,  Chih-Tsung Shih ,  Ming-Chia Li ,  Chein-Shiu Kuo ,  Hung-Chi Chien ,  Chang-Sheng Chu

IPC: G01N21/00 ,  C12Q1/68 ,  G01N21/64 ,  G01N21/77

CPC classification number: C12Q1/6869 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/648 ,  G01N21/7703 ,  G01N2021/6439 ,  G01N2201/08 ,  G01N2201/12 ,  C12Q2563/155 ,  C12Q2561/113

Abstract: Embodiments encompass a single-molecule detection system and methods of using the detection system to detect an object. Further, embodiments encompass a detection system comprising a movable light coupler, a waveguide, and a light detector. Embodiments further encompass methods of single-molecule detection, including methods of single-molecule nucleic acid sequencing.

公开(公告)号：US09772279B2

公开(公告)日：2017-09-26

申请号：US14622886

申请日：2015-02-15

Applicant: The Coca-Cola Company

Inventor： Daniel P. Campbell ,  Jayme Caspall ,  Janet Cobb-Sullivan ,  Kenneth E. Johnson ,  Robert E. Jones ,  Larry Starr ,  Michael Slawson ,  Ruoya Wang

IPC: G01N21/45 ,  G05D7/00 ,  G01N21/41 ,  G01N21/77 ,  G01N21/94 ,  G01N21/17 ,  G01N33/00

CPC classification number: G01N21/41 ,  G01N21/45 ,  G01N21/7703 ,  G01N21/94 ,  G01N33/004 ,  G01N33/0044 ,  G01N33/0047 ,  G01N2021/1765 ,  G01N2021/458 ,  G01N2021/7716 ,  G01N2021/773 ,  G01N2021/7776 ,  G01N2021/7779 ,  G01N2201/06113 ,  G01N2201/08 ,  G05D7/00

Abstract: A system and method for the monitoring of carbon dioxide (CO2) for chemical contaminants. The carbon dioxide monitoring system includes a contaminant sensor that is configured to detect trace amounts of contaminants in CO2 that is pumped through it in real time. The contaminant sensor includes an interferometer configured to track the amount of contaminants.

公开(公告)号：US20170268991A1

公开(公告)日：2017-09-21

申请号：US15617246

申请日：2017-06-08

Applicant: Infineon Technologies AG

Inventor： Ventsislav Lavchiev ,  Thomas Grille ,  Ursula Hedenig ,  Bernhard Jakoby

IPC: G01N21/27 ,  G01N21/77 ,  G01N21/03

CPC classification number: G01N21/27 ,  G01N21/0303 ,  G01N21/7703 ,  G01N2021/0382 ,  G01N2201/08

Abstract: A sensor system having coupling structures is disclosed. The system includes an input coupling structure, an interaction region, and an output coupling structure. The input coupling structure is configured to receive emitted light at a selected coupling efficiency and may provide filtering of the emitted light for a selected wavelength. The interaction region is coupled to the input coupling structure and configured to interact the light from the input coupling structure with a specimen. The output coupling structure is coupled to the interaction region and configured to provide interacted light from the interaction region to the detector.

公开(公告)号：US09759704B2

公开(公告)日：2017-09-12

申请号：US14846163

申请日：2015-09-04

Applicant: Waukesha Electric Systems, Inc.

Inventor： Paul Lefeber ,  Jeffrey J. Nemec

IPC: G01N21/85 ,  G01N33/03 ,  G01N21/94

CPC classification number: G01N33/03 ,  G01N21/27 ,  G01N21/94 ,  G01N2201/062 ,  G01N2201/08

Abstract: A system and a process for detecting oil quality includes a light source configured to generate light within an oil container and a sensor configured to detect light from the light source after it has traversed through the oil in the oil container and generate an output signal. The system and process further includes a monitor configured to receive the output signal from the sensor and determine an oil quality of an oil in the oil container.

公开(公告)号：US20170254746A1

公开(公告)日：2017-09-07

申请号：US15506440

申请日：2015-08-24

Applicant: TOHOKU UNIVERSITY

Inventor： Shigetoshi Sugawa ,  Rihito Kuroda

IPC: G01N21/35

CPC classification number: G01N21/31 ,  A61B5/1112 ,  A61B5/1122 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1477 ,  A61B5/4227 ,  A61B5/6898 ,  A61B2505/07 ,  G01N21/031 ,  G01N21/0332 ,  G01N21/3151 ,  G01N21/35 ,  G01N21/3504 ,  G01N2021/158 ,  G01N2021/3159 ,  G01N2021/3181 ,  G01N2201/08

Abstract: To provide a concentration measurement method that makes it possible to accurately, quickly, and non-destructively measure the concentration of a predetermined chemical component to a trace level of concentration by a simple means, that makes it possible to accurately and quickly measure the concentration of a chemical component within an object to be measured to a nano-order trace concentration level in real time, and that has a versatility which makes it possible to adapt said concentration measurement method to a variety of situations and embodiments. A time sharing method is used to irradiate an object to be measured with each of light of a first wavelength and light of a second wavelength having different light absorption rates with respect to the object to be measured, light of each of said wavelengths that arrives optically through the object to be measured as a result of irradiating with the light of each of said wavelengths is received by a shared light reception sensor, a signal relating to light of the first wavelength and a signal relating to light of the second wavelength are output from the light reception sensor in accordance with the received light and a differential signal of said signals is formed, and the concentration of a chemical component in the object to be measured is derived on the basis of the differential signal.