Biological sensing structures and methods of forming the same
    73.
    发明授权
    Biological sensing structures and methods of forming the same 有权
    生物传感结构及其形成方法

    公开(公告)号:US08846129B2

    公开(公告)日:2014-09-30

    申请号:US13372141

    申请日:2012-02-13

    Abstract: A method of forming of biological sensing structures including a portion of a substrate is recessed to form a plurality of mesas in the substrate. Each of the plurality of mesas has a top surface and a sidewall surface. A first light reflecting layer is deposited over the top surface and the sidewall surface of each mesa. A filling material is formed over a first portion of the first light reflecting layer. A stop layer is deposited over the filling material and a second portion of the first light reflecting layer. A sacrificial layer is formed over the stop layer and is planarized exposing the stop layer. A first opening is formed in the stop layer and the first light reflecting layer. A second light reflecting layer is deposited over the first opening. A second opening is formed in the second light reflecting layer.

    Abstract translation: 形成包括衬底的一部分的生物感测结构的方法被凹进以在衬底中形成多个台面。 多个台面中的每一个具有顶表面和侧壁表面。 第一光反射层沉积在每个台面的顶表面和侧壁表面上。 在第一光反射层的第一部分上形成填充材料。 沉积在填充材料上的停止层和第一光反射层的第二部分。 牺牲层形成在停止层上并且被平坦化地暴露停止层。 在停止层和第一光反射层中形成第一开口。 第二光反射层沉积在第一开口上。 在第二光反射层中形成第二开口。

    Device for Determination of Gas Concentration
    76.
    发明申请
    Device for Determination of Gas Concentration 有权
    气体浓度测定装置

    公开(公告)号:US20130258315A1

    公开(公告)日:2013-10-03

    申请号:US13851879

    申请日:2013-03-27

    Abstract: A device can be used for establishing gas concentrations in an examination volume. A radiation source is configured to generate an electromagnetic beam. A beam guiding apparatus is arranged downstream of the radiation source. The beam guiding apparatus is configured to set a plurality of variations of beam guidance of the beam entering the beam guiding apparatus in an observation plane in the examination volume. A spectrometer is arranged downstream of the beam guiding apparatus. The spectrometer is configured to carry out a spectral analysis of the beam leaving the beam guiding apparatus. An evaluation unit is configured to establish in the observation plane a 2D concentration distribution for one or more gases in the examination volume on the basis of the spectral analysis for different variations of beam guidance.

    Abstract translation: 一种装置可用于建立检查体积中的气体浓度。 辐射源被配置为产生电磁波束。 光束引导装置布置在辐射源的下游。 光束引导装置被配置为在检查体积中的观察平面中设置进入光束引导装置的光束的多个波束引导变化。 光谱仪布置在光束引导装置的下游。 光谱仪被配置为对离开光束引导装置的光束进行光谱分析。 评估单元被配置为基于对波束引导的不同变化的频谱分析,在观察平面中建立检查体积中的一种或多种气体的2D浓度分布。

    Real-time PCR monitoring apparatus
    77.
    发明授权
    Real-time PCR monitoring apparatus 有权
    实时PCR监测仪

    公开(公告)号:US08427643B2

    公开(公告)日:2013-04-23

    申请号:US12598061

    申请日:2008-06-17

    Abstract: The present invention relates to a real-time PCR monitoring apparatus for real-time monitoring production of reaction product produced during the reaction while performing nucleic acid amplification such as PCR for various kinds of trace samples. Specifically, the present invention relates to an apparatus for real-time monitoring biochemical reaction for efficiently dividing interference between an excitation light and a fluorescence, which includes a polarizer, a polarizing beam splitter, a polarization converter and so on.

    Abstract translation: 本发明涉及一种用于实时监测在反应过程中产生的反应产物的实时PCR监测装置,同时对各种痕量样品进行核酸扩增如PCR。 具体地说,本发明涉及一种用于实时监测生化反应的装置,用于有效地分离激发光和荧光之间的干扰,其包括偏振器,偏振分束器,偏振转换器等。

    Spectrophotometer system with modular 45/0 head
    78.
    发明授权
    Spectrophotometer system with modular 45/0 head 有权
    分光光度计系统,带模块化45/0头

    公开(公告)号:US08130377B2

    公开(公告)日:2012-03-06

    申请号:US12486334

    申请日:2009-06-17

    Abstract: In one embodiment, the invention is a spectrophotometer with a modular 45/0 head. One embodiment of an apparatus for measuring a reflectance of a sample includes a plurality of light emitting diodes for emitting light, a reflective housing positioned above the plurality of light emitting diodes, where the reflective housing is a dome having a plurality of apertures formed around its perimeter, a sample channel for capturing a first portion of the light, where the first portion of the light interacts with the sample, and a reference channel for capturing a second portion of the light, where the second portion of the light is independent of the sample.

    Abstract translation: 在一个实施例中,本发明是具有模块化45/0头的分光光度计。 用于测量样品的反射率的装置的一个实施例包括多个用于发射光的发光二极管,位于多个发光二极管上方的反射壳体,其中反射壳体是具有围绕其形成的多个孔的圆顶 周边,用于捕获光的第一部分的样本通道,其中光的第一部分与样本相互作用;以及用于捕获光的第二部分的参考通道,其中光的第二部分独立于 样品。

    Reflective scatterometer
    79.
    发明授权
    Reflective scatterometer 有权
    反射散射仪

    公开(公告)号:US07864324B2

    公开(公告)日:2011-01-04

    申请号:US12352069

    申请日:2009-01-12

    Abstract: A reflective scatterometer capable of measuring a sample is provided. The reflective scatterometer includes a paraboloid mirror, a light source, a first reflector, a second reflector and a detector. The paraboloid mirror has an optical axis and a parabolic surface, wherein the sample is disposed on the focal point of the parabolic surface and the normal direction of the sample is parallel with the optical axis. A collimated beam generated from the light source is reflected by the first reflector to the parabolic surface and then is reflected by the parabolic surface to the sample to form a first diffracted beam. The first diffracted beam is reflected by the parabolic surface to the second reflector and is then reflected by the second reflector to the detector.

    Abstract translation: 提供了能够测量样品的反射式散射仪。 反射式散射仪包括抛物面镜,光源,第一反射器,第二反射器和检测器。 抛物面镜具有光轴和抛物面,其中样品设置在抛物面的焦点上,并且样品的法线方向与光轴平行。 从光源产生的准直光束被第一反射器反射到抛物线表面,然后被抛物面反射到样品以形成第一衍射光束。 第一衍射光束被抛物面反射到第二反射器,然后被第二反射器反射到检测器。

    Surface plasmon detection using curved surface prism and reflecting member
    80.
    发明授权
    Surface plasmon detection using curved surface prism and reflecting member 失效
    使用曲面棱镜和反射构件进行表面等离子体检测

    公开(公告)号:US07760361B2

    公开(公告)日:2010-07-20

    申请号:US12169354

    申请日:2008-07-08

    Inventor: Kentaro Furusawa

    CPC classification number: G01N21/553 G01N2201/0636

    Abstract: A detection apparatus arranges a light source, a curved surface prism having a curved surface and a plane surface, a metal film placed on the plane surface of the prism to be held adjacently to a test sample, and a reflecting member for reflecting light such that light emitted by the light source enters the prism through the curved surface and is reflected by the metal film, then by the reflecting member, and again by the metal film. The detection apparatus is adapted to detect an optical change in the test sample by means of surface plasmon generated on the metal film. In the detection apparatus, divergent light is made to enter the prism through the curved surface to collimate the incident light by means of the curved surface. The apparatus can suppress the broadening of the resonant bandwidth so as to operate as a monitor with a higher degree of precision.

    Abstract translation: 检测装置配置光源,具有弯曲面和平面的曲面棱镜,配置在与被测试样相邻地保持在棱镜的平面上的金属膜和反射光,使得 由光源发射的光通过弯曲表面进入棱镜,并被金属膜反射,然后被反射构件反射,并再次被金属膜反射。 检测装置适于通过在金属膜上产生的表面等离子体激元检测测试样品中的光学变化。 在检测装置中,使发散光通过弯曲表面进入棱镜,以通过弯曲表面准直入射光。 该装置可以抑制谐振带宽的扩大,从而以更高的精度操作为监视器。

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