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公开(公告)号：KR20180043408A
公开(公告)日：2018-04-27
申请号：KR20187011145
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233 , A61K31/4704 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/56
CPC classification number: C07C205/43 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/233 , C07D215/56 , G01N33/5041 , G01N33/6872 , Y02P20/55
Abstract: 본발명은하기화학식 2의카르복실산을커플링제의존재하에하기화학식 3의아닐린과커플링시키는것을포함하는, 하기화학식 1의화합물의제조방법을제공한다.
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2.发明申请SOLID FORMS OF 2-(2, 4-DIFLUOROPHENYL)-6-(1-(2,6-DIFLUOROPHENYL)UREIDO)NICOTINAMIDE 审中-公开2-（2,4-二氟苯基）-6-（1-（2,6-二氟苯基）尿苷）的固体形式NICOTINAMIDE
公开(公告)号：WO2010093889A3
公开(公告)日：2010-10-28
申请号：PCT/US2010024053
申请日：2010-02-12
Applicant: VERTEX PHARMA , HURREY MICHAEL , ALARGOV DIMITAR , JOHNSTON STEVEN C , ROEPER STEFANIE , SNOONIAN JOHN R , COWANS BRETT A , VLAHOVA PETINKA , EBERLIN ALEXANDER , EDDLESTON MARK , FRAMPTON CHRIS
Inventor： HURREY MICHAEL , ALARGOV DIMITAR , JOHNSTON STEVEN C , ROEPER STEFANIE , SNOONIAN JOHN R , COWANS BRETT A , VLAHOVA PETINKA , EBERLIN ALEXANDER , EDDLESTON MARK , FRAMPTON CHRIS
IPC: C07D213/82 , A61K31/4418
CPC classification number: C07D213/82
Abstract: This invention relates to solid forms of 2-(2, 4-difluorophenyl)-6-(l- (2,6-difluorophenyl)ureido)nicotinamide and pharmaceutical compositions thereof, and methods and uses therewith.
Abstract translation: 本发明涉及2-（2,4-二氟苯基）-6-（1-（2,6-二氟苯基）脲基）烟酰胺及其药物组合物的固体形式及其方法和用途。
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3.发明申请PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES 审中-公开生产苯基-6-（1-（苯基）尿嘧啶）的方法NICOTINAMIDES
公开(公告)号：WO2010093890A3
公开(公告)日：2010-12-16
申请号：PCT/US2010024054
申请日：2010-02-12
Applicant: VERTEX PHARMA , ROEPER STEFANIE , LOOKER ADAM R , MARTINOT THEODORE A , NEUBERT-LANGILLE BOBBIANNA , RYAN MICHAEL P , SNOONIAN JOHN R
Inventor： ROEPER STEFANIE , LOOKER ADAM R , MARTINOT THEODORE A , NEUBERT-LANGILLE BOBBIANNA , RYAN MICHAEL P , SNOONIAN JOHN R
IPC: C07D213/80 , A61K31/4418 , A61P29/00 , A61P37/06 , C07D213/803
CPC classification number: C07D213/80 , C07D213/803
Abstract: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
Abstract translation: 本发明涉及制备可用作p38激酶抑制剂的化合物的方法。 本发明的方法适用于大规模制备，并以高纯度产生稳定的苯基-6-（1-（苯基）脲基）烟酰胺。
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4.发明申请SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 审中-公开N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-羧酰胺的固体形式
公开(公告)号：WO2009038683A3
公开(公告)日：2010-08-26
申请号：PCT/US2008010728
申请日：2008-09-15
Applicant: VERTEX PHARMA , DEMATTEI JOHN , FENG YUSHI , HARRISON CRISTIAN , LOOKER ADAM , MUDUNURI PRAVEEN , ROEPER STEFANIE , ZHANG YUEGANG
Inventor： DEMATTEI JOHN , FENG YUSHI , HARRISON CRISTIAN , LOOKER ADAM , MUDUNURI PRAVEEN , ROEPER STEFANIE , ZHANG YUEGANG
IPC: C07D215/233
CPC classification number: C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
Abstract: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
Abstract translation: 本文描述了固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺，包括其结晶形式。
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5.发明专利
公开(公告)号：HRP20241608T1
公开(公告)日：2025-01-31
申请号：HRP20241608
申请日：2018-11-30
Applicant: VERTEX PHARMA
Inventor： LEMERCIER LEWANDOWSKI BERENICE , LEWIS ROBERT , LOOKER ADAM , MORGAN ADAM , ROEPER STEFANIE , RYAN MICHAEL , SOLSONA ROCABERT JUAN GABRIEL , WILDE NATHAN
IPC: C07D215/56 , C07B59/00 , C07C33/18 , C07C69/96
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Patent Agency Ranking
公开(公告)号：AU2020286424A1
公开(公告)日：2022-01-06
申请号：AU2020286424
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM , COTTRELL KEVIN MICHAEL
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
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公开(公告)号：CO2021005884A2
公开(公告)日：2021-05-20
申请号：CO2021005884
申请日：2021-05-05
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , BRODNEY MICHAEL AARON , ECCLES MARY ELIZABETH , GAGNON KEVIN JAMES , HOOD SARAH CAROL , HUSSEY JOSHUA KENNEDY , LOOKER ADAM , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , TANG QING , WALDO MICHAEL , BANDARAGE UPUL KEERTHI , BOUCHER DIANE M , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , DEWEY FANNING LEV TYLER , FIMOGNARI JR ROBERT FRANCIS , GARCIA BARRANTES PEDRO M , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , XU JINWANG , MAXWELL BRAD D , COTTRELL KEVIN MICHAEL
IPC: A61P1/16 , A61K31/4162 , A61K31/4178 , A61K31/4196 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61P11/00 , C07D471/14 , C07D487/04 , C07D487/14 , C07D519/00
Abstract: Nuevos compuestos, composiciones y métodos para usar y preparar los mismos, los cuales pueden ser útiles para tratar la deficiencia de alfa-1 antitripsina (AATD).
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公开(公告)号：AU2018375186A1
公开(公告)日：2020-06-18
申请号：AU2018375186
申请日：2018-11-30
Applicant: VERTEX PHARMA
Inventor： LEMERCIER LEWANDOWSKI BERENICE , LEWIS ROBERT , LOOKER ADAM , MORGAN ADAM , ROEPER STEFANIE , RYAN MICHAEL , SOLSONA ROCABERT JUAN , WILDE NATHAN
IPC: C07D215/56 , C07B59/00 , C07C33/18 , C07C69/96
Abstract: The disclosure provides processes for synthesizing compounds for use as CFTR modulators.
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公开(公告)号：UY38403A
公开(公告)日：2020-04-30
申请号：UY38403
申请日：2019-10-07
Applicant: VERTEX PHARMA
Inventor： JONES PETER , NUHANT PHILIPPE MARCEL , BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE M , DEWEY FANNING LEV TYLER , ECCLES MARY ELIZABETH , FIMOGNARI JR ROBERT FRANCIS , GAGNON KEVIN JAMES , BOYD MICHAEL JOHN , GARCÍA BARRANTES PEDRO M , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , HUSSEY JOSHUA KENNEDY , JOHNSON JR , KESAVAN SARATHY , LOOKER ADAM , MAXWELL BRAD D , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , WALDO MICHAEL , XU JINWANG , DAMAGNEZ VERONIQUE , BRODNEY MICHAEL AARON
IPC: A61P1/16 , A61K31/4162 , A61K31/437 , A61K31/497 , A61P11/00 , C07D471/14 , C07D487/04 , C07D487/14 , C07F5/04
Abstract: Nuevos compuestos, composiciones y métodos de uso y preparación de los mismos, que pueden ser útiles para el tratamiento de la deficiencia de alfa-1 antitripsina (AATD).
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公开(公告)号：CA3082444A1
公开(公告)日：2019-06-06
申请号：CA3082444
申请日：2018-11-30
Applicant: VERTEX PHARMA
Inventor： LEMERCIER LEWANDOWSKI BERENICE , LEWIS ROBERT , LOOKER ADAM , MORGAN ADAM , ROEPER STEFANIE , RYAN MICHAEL , SOLSONA ROCABERT JUAN GABRIEL , WILDE NATHAN
IPC: C07D215/56 , C07B59/00 , C07C33/18 , C07C69/96
Abstract: The disclosure provides processes for synthesizing compounds for use as CFTR modulators.
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