公开(公告)号：DE69024322T2

公开(公告)日：1996-10-31

申请号：DE69024322

申请日：1990-10-18

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  KLEIN LARRY L ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  A61K31/435

Abstract: Isothiazolo-quinoline derivatives of the formula I which may exist as tautomers (formula II) are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases. wherein R is selected from (a) lower alkyl, (b) haloalkyl, (c) lowercycloalkyl, (d) alkylamino, (e) an aromatic heterocyclic group and (f) a phenyl group; W, X and Z are independently selected from hydrogen, halogen and lower alkyl; and Y is selected from a (a) phenyl group, (b) -NR2R3, (c) a bicyclic N-containing heterocyclic group, and (d) -OR10, wherein R10 is hydrogen, lower alkyl or a phenyl group; or any two of W, X, Y and Z taken together form a fused, substituted or unsubstituted, aromatic group or heterocyclic group.

公开(公告)号：ES2083990T3

公开(公告)日：1996-05-01

申请号：ES90119985

申请日：1990-10-18

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  KLEIN LARRY L ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  A61K31/435

Abstract: Isothiazolo-quinoline derivatives of the formula I which may exist as tautomers (formula II) are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases. wherein R is selected from (a) lower alkyl, (b) haloalkyl, (c) lowercycloalkyl, (d) alkylamino, (e) an aromatic heterocyclic group and (f) a phenyl group; W, X and Z are independently selected from hydrogen, halogen and lower alkyl; and Y is selected from a (a) phenyl group, (b) -NR2R3, (c) a bicyclic N-containing heterocyclic group, and (d) -OR10, wherein R10 is hydrogen, lower alkyl or a phenyl group; or any two of W, X, Y and Z taken together form a fused, substituted or unsubstituted, aromatic group or heterocyclic group.

公开(公告)号：DE69024322D1

公开(公告)日：1996-02-01

申请号：DE69024322

申请日：1990-10-18

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  KLEIN LARRY L ,  SHEN LINUS L

IPC: A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P35/00 ,  C07C333/06 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  A61K31/435

Abstract: Isothiazolo-quinoline derivatives of the formula I which may exist as tautomers (formula II) are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases. wherein R is selected from (a) lower alkyl, (b) haloalkyl, (c) lowercycloalkyl, (d) alkylamino, (e) an aromatic heterocyclic group and (f) a phenyl group; W, X and Z are independently selected from hydrogen, halogen and lower alkyl; and Y is selected from a (a) phenyl group, (b) -NR2R3, (c) a bicyclic N-containing heterocyclic group, and (d) -OR10, wherein R10 is hydrogen, lower alkyl or a phenyl group; or any two of W, X, Y and Z taken together form a fused, substituted or unsubstituted, aromatic group or heterocyclic group.

公开(公告)号：DE3853459D1

公开(公告)日：1995-05-04

申请号：DE3853459

申请日：1988-10-04

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  CROWLEY STEVEN R ,  PLATTNER JACOB J

IPC: A61K31/16 ,  A61K31/21 ,  A61K31/215 ,  A61K31/255 ,  A61K31/265 ,  A61K31/42 ,  A61K31/421 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K38/55 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07C233/16 ,  C07C235/08 ,  C07C237/08 ,  C07C271/22 ,  C07C271/34 ,  C07C305/04 ,  C07C307/06 ,  C07C309/64 ,  C07C317/28 ,  C07C317/44 ,  C07C323/52 ,  C07C323/60 ,  C07C323/64 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D233/64 ,  C07D263/22 ,  C07D263/24 ,  C07D295/20 ,  C07D405/12 ,  C07D413/06 ,  A61K38/07

Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: wherein A is a substituent; W is CO or CHOH and U is CH2 or NR2 wherein R2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkyl, benzyl, (alpha,alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof. Also disclosed are compositions, methods and kits for treating glaucoma or reducing and/or controlling intraocular pressure wherein the renin inhibiting compound is administered in combination with a beta-adrenergic antagonist, a steroidal antiinflammatory agent or an angiotensin converting enzyme inhibiting compound.

公开(公告)号：AU7925894A

公开(公告)日：1995-05-04

申请号：AU7925894

申请日：1994-09-30

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  LI QUN ,  COOPER CURT S ,  FUNG ANTHONY K L ,  LEE CHEUK M ,  PLATTNER JACOB J

IPC: C07D491/052 ,  A61K31/40 ,  A61K31/435 ,  A61K31/495 ,  A61K31/54 ,  A61K38/00 ,  A61P31/04 ,  C07D213/61 ,  C07D213/68 ,  C07D455/02 ,  C07D471/04 ,  C07D491/107 ,  C07D491/113 ,  C07D491/16 ,  C07D519/00 ,  C07K5/06 ,  A61K31/535

Abstract: Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R is cycloalkyl of from three to eight carbon atoms or substituted phenyl; R is selected from the group consisting of (a) halogen, (b) loweralkyl, (c) loweralkenyl, (d) cycloalkyl of from three to eight carbons, (e) cycloalkenyl of from four to eight carbons, (f) loweralkoxy, (g) aryloxy, (h) aryl(loweralkyl)oxy, (i) aryl(loweralkyl), (j) cycloalkyl(loweralkyl), (k) amino, (l) (loweralkyl)amino, (m) aryl(loweralkyl)amino, (n) hydroxy substituted (loweralkyl)amino, (o) phenyl, (p) substituted phenyl, (q) bicyclic nitrogen-containing heterocycle, (r) nitrogen-containingaromatic heterocycle, and (s) nitrogen-containing heterocycle having formula (Ia) where x is between zero and three; R is halogen; R is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group; R is hydrogen, loweralkyl, halo(loweralkyl), or -NR R ; and R is loweralkyl, as wellas pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.

公开(公告)号：ITMI913081A1

公开(公告)日：1992-05-20

申请号：ITMI913081

申请日：1991-11-19

Applicant: ABBOTT LAB

Inventor： KEMPF DALE J ,  NORBECK DANIEL W ,  CODACOVI LYNN M ,  PLATTNER JACOB J ,  ZHAO CHEN ,  SHAM HING L ,  WITTENBERGER STEVEN J

IPC: A61K31/42 ,  A61K31/421 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61K31/435 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K38/00 ,  A61P31/12 ,  A61P31/18 ,  A61P43/00 ,  C07C53/134 ,  C07C211/00 ,  C07C215/18 ,  C07C215/20 ,  C07C215/28 ,  C07C215/30 ,  C07C215/80 ,  C07C219/18 ,  C07C233/40 ,  C07C237/10 ,  C07C237/22 ,  C07C269/04 ,  C07C271/02 ,  C07C271/16 ,  C07C271/20 ,  C07C271/22 ,  C07C271/34 ,  C07C275/24 ,  C07D20060101 ,  C07D213/26 ,  C07D213/30 ,  C07D213/34 ,  C07D213/36 ,  C07D213/40 ,  C07D213/54 ,  C07D213/56 ,  C07D213/61 ,  C07D213/75 ,  C07D213/79 ,  C07D215/20 ,  C07D233/54 ,  C07D233/84 ,  C07D235/14 ,  C07D235/16 ,  C07D237/10 ,  C07D239/26 ,  C07D241/12 ,  C07D261/08 ,  C07D261/12 ,  C07D263/20 ,  C07D263/32 ,  C07D277/20 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D277/56 ,  C07D295/02 ,  C07D295/13 ,  C07D295/205 ,  C07D295/215 ,  C07D303/36 ,  C07D307/34 ,  C07D307/42 ,  C07D307/66 ,  C07D333/16 ,  C07D333/36 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K14/81

公开(公告)号：CA2099609A1

公开(公告)日：1992-02-25

申请号：CA2099609

申请日：1991-08-23

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  HALLAS ROBERT

IPC: C07D455/03 ,  C07D498/06 ,  C07D498/16 ,  C07D513/06 ,  A61K31/47 ,  A61K31/535 ,  A61K31/54 ,  A61K38/04 ,  C07K5/04 ,  C07K7/06

Abstract: 2099609 9203136 PCTABS00010 Quinobenzoxazine, quinobenzothiazines, and pyrido-acridine derivatives of formula (I), as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R1 is hydrogen or a carboxy-protecting group, R2 and R3 are substituents, A is oxygen, sulfur, or carbon, Z is a halogen or a nitrogen-containing group, X is hydrogen, halogen or alkyl, and W is hydrogen, alkyl, amino or halogen. The compounds have potent antineoplastic activity.

公开(公告)号：CA2081891A1

公开(公告)日：1991-11-03

申请号：CA2081891

申请日：1991-05-01

Applicant: ABBOTT LAB

Inventor： PLATTNER JACOB J ,  COOPER CURT S ,  LI QUN ,  CHU DANIEL T ,  LEE CHEUK M

IPC: A61K31/435 ,  A61K31/47 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K38/00 ,  A61P31/04 ,  C07D213/68 ,  C07D455/02 ,  C07D471/04 ,  C07D471/08 ,  C07D491/10 ,  C07D491/16 ,  C07D495/16 ,  C07D519/00 ,  C07K5/06 ,  A61K31/495 ,  C07K5/04 ,  C07K7/06 ,  A61K38/04

公开(公告)号：CA1287445C

公开(公告)日：1991-08-06

申请号：CA500188

申请日：1986-01-23

Applicant: LULY JAY R ,  ABBOTT LAB

Inventor： LULY JAY R ,  ROSENBERG SAUL H ,  PLATTNER JACOB J ,  FUNG ANTHONY K

IPC: A61K31/16 ,  A61K31/165 ,  A61K31/47 ,  A61K31/55 ,  A61K38/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07D233/64 ,  C07K5/04

Abstract: PEPTIDYLAMINODIOLS The invention relates to renin inhibiting compounds of the formula: wherein R10 is , , , or ; A is hydrogen or an N-protecting group; w is 0 or 1; B is hydrogen, hydroxy, NH, N-alkyl, loweralkyl or arylalkyl; with the proviso that when w is 1, B is NH and when w is 0, B is hydrogen, hydroxy, loweralkyl or arylalkyl; R1 is loweralkyl or lipophilic or aromatic or hydrophilic amino acid side chains; m is 1-3; n is 1-3; p is 1-3; q is 1-3; s is 1-3; t is 0-2; R2 is hydrogen or loweralkyl; R3 and R4 are independently selected from loweralkyl, lipophilic or aromatic amino acid side chains; R5 and R7 are independently selected from hydrogen or loweralkyl; and R6 is hydrogen, loweralkyl, vinyl, arylalkyl or wherein R8 is hydrogen or loweralkyl, X is 0, NH or S and R9 is hydrogen, loweralkyl or alkanoyl or XR9 together can be loweralkylsulfonyl, N3 or Cl.

公开(公告)号：DK59991A

公开(公告)日：1991-04-04

申请号：DK59991

申请日：1991-04-04

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K L ,  BAKER WILLIAM R ,  BOYD STEVEN A ,  KEMPF DALE J ,  ARMIGER YOEK-LIN ,  ROSENBERG SAUL H ,  DE BISWANATH ,  PLATTNER JACOB J ,  SHAM HING LEUNG ,  KLEINERT HOLLIS D ,  MANTEI ROBERT A

IPC: A61K31/16 ,  A61K31/19 ,  A61K31/265 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/66 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/08 ,  C07C237/22 ,  C07C317/28 ,  C07C323/57 ,  C07C323/58 ,  C07D203/18 ,  C07D211/44 ,  C07D211/46 ,  C07D211/62 ,  C07D211/96 ,  C07D233/36 ,  C07D233/54 ,  C07D233/56 ,  C07D263/22 ,  C07D295/185 ,  C07D401/12 ,  C07D407/12 ,  C07D413/12 ,  C07D521/00 ,  C07C237/20 ,  C07D205/04 ,  C07D233/64 ,  C07D295/182 ,  C07D405/12 ,  C07K5/06

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), SO2, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.