公开(公告)号：AT323681T

公开(公告)日：2006-05-15

申请号：AT01273519

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：PL378116A1

公开(公告)日：2006-03-06

申请号：PL37811604

申请日：2004-02-26

Applicant: ABBOTT LAB

Inventor： HASVOLD LISA A ,  HEXAMER LAURA ,  LI GAOQUAN ,  LIN NAN-HORNG ,  SHAM HING ,  SOWIN TOM ,  SULLIVAN GERARD M ,  WANG LE ,  XIA PING XIA

IPC: C07D243/38 ,  A61K31/551 ,  A61P35/00 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/10

公开(公告)号：DK1200412T3

公开(公告)日：2004-03-22

申请号：DK00950584

申请日：2000-07-21

Applicant: ABBOTT LAB

Inventor： WANG LE ,  LI QUN ,  WOODS KEITH W ,  SHAM HING L

IPC: C07D233/64 ,  A61K31/4164 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/00

公开(公告)号：AT254110T

公开(公告)日：2003-11-15

申请号：AT00950584

申请日：2000-07-21

Applicant: ABBOTT LAB

Inventor： WANG LE ,  LI QUN ,  SHAM HING L ,  WOODS KEITH W

IPC: C07D233/64 ,  A61K31/4164 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54

公开(公告)号：PE06872002A1

公开(公告)日：2002-08-03

申请号：PE0011982001

申请日：2001-11-29

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY II STEPHEN L ,  LI QUN ,  LIN NAN-HORNG ,  ROCKWAY TODD W ,  SULLIVAN GERARD M ,  WANG GARY T ,  WANG XILU ,  WANG WEIBO ,  WANG LE ,  TONG YUNSONG ,  SHAM HING L ,  MANTEI ROBERT A ,  LI TONGMEI ,  HASVOLD LISA A

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D401/01

CPC classification number: C07D233/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: SE REFIERE A IMIDAZOLES Y TIAZOLES DE FORMULA I DONDE E ES UN ANILLO CARBOCICLICO AROMATICO O NO AROMATICO DE CINCO, SEIS O SIETE MIEMBROS DONDE ENTRE 0-3 ATOMOS DE CARBONO ESTAN REEMPLAZADOS POR NITROGENO; F Y G SON C Y N CON LA SALVEDAD DE QUE CUANDO UNO DE F Y G ES N EL OTRO ES C; L1 Y L2 SON ALQUENILENO, ALQUINILENO, O, NR9, C(O), S, ENTRE OTROS; X ES S, NR7; R1 ES ARILO, ARILALQUILO, HETEROCICLO, (HETEROCICLO)ALQUILO; R2 ES H, ALCOXI, ALQUILO, AMINO, AMINOALQUILO, CIANO, CIANOALQUILO, ENTRE OTROS; R3 ES ARILO, HETEROCICLO Y CICLOALQUILO; R4-R6 SON H, NR9C(O), C(N)NR9, ALCANOILO, ALQUENILO, ENTRE OTROS; R7 ES H, ALQUILO, ARILO, CICLOALQUILO, ENTRE OTROS; R9 ES H, ALCOXIALQUILO, ALQUILO, AMIDOALQUILO, ENTRE OTROS; R12 ES H, ALCOXI, ALQUILO, ENTRE OTROS; m, n, p, q SON 0-4. SON COMPUESTOS PREFERIDOS 4-(((6-CLORO-2-(3-CLOROFENIL)-3-PIRIDINIL)METOXI)(1-METIL-1H-IMIDAZOL-5-IL)METIL)BENZONITRILO, 4-(((2-(3-CLOROFENIL)-6-METIL-3-PIRIDINIL)METOXI)(1-METIL-1H-IMIDAZOL-5-IL)METIL)BENZONITRILO, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA FARNESIL TRANSFERASA Y SON UTILES PARA EL TRATAMIENTO DE TUMORES

公开(公告)号：CA2378942A1

公开(公告)日：2001-02-08

申请号：CA2378942

申请日：2000-07-21

Applicant: ABBOTT LAB

Inventor： SHAM HING L ,  LI QUN ,  WANG LE ,  WOODS KEITH W

IPC: C07D233/64 ,  A61K31/4164 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54

Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein R1 is selected from the group consisting of hydrogen, methy l, ethyl, propyl, and isolpropyl; and one of R2 or R3 is 3,4,5-trimethoyxphenyl , and the other is phenyl substituted with one, two, or three substitutents independently selected from the group consisting of alkoxy, halo, and -NR4R5 , wherein R4 and R5 are independently selected from the group consisting of hydrogen and alkyl, inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.

公开(公告)号：AU5227999A

公开(公告)日：2000-02-21

申请号：AU5227999

申请日：1999-07-23

Applicant: ABBOTT LAB

Inventor： GWALTNEY STEPHEN L II ,  JAE HWAN-SOO ,  KALVIN DOUGLAS M ,  LIU GANG ,  SHAM HING L ,  LI QUN ,  CLAIBORNE AKIYO K ,  WANG LE ,  BARR KENNETH J ,  WOODS KEITH W

IPC: C07D263/10 ,  C07D263/14 ,  C07D413/04 ,  C07D471/04 ,  C07D473/04 ,  A61K31/421 ,  A61K31/422

公开(公告)号：CA2744708C

公开(公告)日：2017-07-11

申请号：CA2744708

申请日：2009-12-04

Applicant: ABBOTT LAB ,  THE WALTER AND ELIZA HALL INST OF MEDICAL RES

Inventor： BRUNCKO MILAN ,  DAI YUJIA ,  DING HONG ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON R ,  MANTEI ROBERT A ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PARK CHEOL-MIN ,  PETROS ANDREW M ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD M ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL D ,  CZABOTAR PETER EDWARD ,  LESSENE GUILLAUME LAURENT ,  COLMAN PETER MALCOM

IPC: C07D405/12 ,  A61K31/395 ,  A61K31/496 ,  A61P35/00 ,  C07D295/04 ,  C07D309/00 ,  C07D401/00 ,  C07D403/12

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti- apoptotic Bcl-2 protein. The compounds include those of Formula (I): (see formula I)

公开(公告)号：MY162157A

公开(公告)日：2017-05-31

申请号：MYPI20094303

申请日：2008-04-16

Applicant: ABBOTT LAB

Inventor： ELMORE STEVEN W ,  WENDT MICHAEL D ,  TAO ZHI-FU ,  MADAR DAVID ,  SOUERS ANDREWS J ,  BRUNCKO MILAN ,  SONG XIAOHONG ,  WANG XILU ,  HASVOLD LISA A ,  WANG LE ,  KUNZER AARON R ,  PARK CHEOL-MIN

IPC: C07D209/34 ,  A61K31/404 ,  A61P35/00 ,  C07D401/12 ,  C07D413/06 ,  C07D417/04

Abstract: Compounds of formula (1) which inhibit the activity of anti-apoptotic .tvkl-1 protein. compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mel-I protein arc disclosed.

公开(公告)号：ZA201108616B

公开(公告)日：2015-12-23

申请号：ZA201108616

申请日：2011-11-23

Applicant: ABBOTT LAB

Inventor： MANTEI ROBERT ,  WANG XILU ,  WANG GARY T ,  SULLIVAN GERARD ,  SONG XIAOHONG ,  HEXAMER LAURA ,  ELMORE STEVEN ,  DING HONG ,  HANSEN TODD M ,  WENDT MICHAEL ,  WANG LE ,  TAO ZHI-FU ,  SOUERS ANDREW J ,  KUNZER AARON R ,  HASVOLD LISA ,  DOHERTY GEORGE ,  BRUNCKO MILAN

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.