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    2-피롤리돈기를 포함하는 옥사졸리디논 유도체 또는 이의 약학적으로 허용 가능한 염 및 이들의 제조방법
    12.
    发明公开
    2-피롤리돈기를 포함하는 옥사졸리디논 유도체 또는 이의 약학적으로 허용 가능한 염 및 이들의 제조방법 有权
    含有2-吡咯烷酮基或其药学上可接受的盐的氧杂环丁酮衍生物及其制备方法

    公开(公告)号：KR1020120056078A

    公开(公告)日：2012-06-01

    申请号：KR1020100117602

    申请日：2010-11-24

    Applicant: 한국과학기술연구원

    Inventor： 금교창 ,  김은경 ,  배애님 ,  김유승 ,  강순방 ,  서선희 ,  바타라이디팍

    IPC: C07D413/10 ,  A61K31/422 ,  A61P31/04

    CPC classification number: Y02A50/473 ,  Y02A50/481

    Abstract: PURPOSE: An antibacterial composition containing novel oxazolidinone derivative is provided to ensure antibacterial activity against gram positive bacteria. CONSTITUTION: A novel oxazolidinone derivative with antibacterial activity is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 or the salt thereof comprises: a step of reacting an amine group of a compound of chemical formula 2 with a compound of chemical formula 3 or 4; and a step of substituting a hydroxyl group of an oxazolidinone derivative or a pharmaceutically acceptable salt thereof with a halogen group or methoxy group. An antibacterial composition contains the oxazolidinone derivative of chemical formula 1 or a salt thereof as an active ingredient.

    Abstract translation: 目的：提供含有新恶唑烷酮衍生物的抗菌组合物，以确保对革兰氏阳性菌的抗菌活性。 构成：具有抗菌活性的新型恶唑烷酮衍生物由化学式1表示。化学式1化合物或其盐的制备方法包括：使化学式2的化合物的胺基与 化学式3或4; 以及将恶唑烷酮衍生物或其药学上可接受的盐的羟基与卤素基或甲氧基取代的步骤。 抗菌组合物含有化学式1的恶唑烷酮衍生物或其盐作为活性成分。

    인듐을 이용한 벤질화된 방향족 화합물의 제조 방법
    16.
    发明公开
    인듐을 이용한 벤질화된 방향족 화합물의 제조 방법 失效
    使用印迹制备苯甲酰化芳族化合物

    公开(公告)号：KR1020010011329A

    公开(公告)日：2001-02-15

    申请号：KR1019990030637

    申请日：1999-07-27

    Applicant: 한국과학기술연구원

    Inventor： 김유승 ,  강순방 ,  금교창 ,  임환정

    IPC: C07C2/68

    Abstract: PURPOSE: A process for preparing benzylated aromatics useful as an intermediate in a synthetic chemical industry or a final compound by benzylation of a benzyl halogen compound and aromatic compound in the presence of an indium catalyst is provided which has the advantage of capable of producing the title compound in a simple manner and being reused and requiring no special solvents. CONSTITUTION: The benzylated aromatics of formula (III) are produced by reaction of a benzyl halogen compound of formula (I) and aromatic compound of formula (II) at 20 to 120deg.C for 1 to 24 hr in the presence of an indium catalyst. In formula, R1, R2 and R3 represent independently H, F, Br, methyl and nitro; R4, R5 and R6 represent independently H, F, Cl, hydroxy, methoxy and methyl, wherein a molar ratio of the aromatic compound and benzyl halogen compound is within the range of 1 to 100 : 1.

    Abstract translation: 目的：提供在铟催化剂存在下，通过苄基卤化合物和芳香族化合物苄基化制备用作合成化学工业中的中间体或最终化合物的苄基化芳烃的方法，其具有能够产生标题的优点 以简单的方式复合并重复使用，不需要特殊的溶剂。 构成：式（III）的苄化芳族化合物是通过式（I）的苄基卤化合物和式（II）的芳族化合物在20至120℃下在铟催化剂存在下反应1至24小时来制备的 。 在式中，R 1，R 2和R 3独立地表示H，F，Br，甲基和硝基; R4，R5和R6独立地表示H，F，Cl，羟基，甲氧基和甲基，其中芳族化合物和苄基卤化合物的摩尔比在1至100:1的范围内。

    7-아미노데스아세톡시세팔로스포린산 유도체의 제조방법
    17.
    发明公开
    7-아미노데스아세톡시세팔로스포린산 유도체의 제조방법 失效
    制备7-氨基乙酰氧基苯甲酸的方法

    公开(公告)号：KR1020000051062A

    公开(公告)日：2000-08-16

    申请号：KR1019990001300

    申请日：1999-01-18

    Applicant: 한국과학기술연구원

    Inventor： 김유승 ,  배애님 ,  강순방 ,  금교창 ,  조상원

    IPC: C07D501/04

    Abstract: PURPOSE: A process for preparing 7-aminodesacetoxycephalosporanic acid useful as an important intermediate for preparing cephalosporin antibiotics is provided which comprises reaction of 3-substituted cephalosporin derivatives in the presence of metal indium or an indium compound. CONSTITUTION: A process comprises the steps of preparing a mixture of 7-aminodesacetoxycephalosporanic acid derivatives (I) and 3-exomethylenecephem derivatives (III) by the reaction of 3-substituted cephalosporin derivative (II) in a mixture solution of an organic solvent and water in the presence of solely indium metal or a mixture of indium metal and metal iodide at 10 to 80°C for 1 to 10 hrs and preparing 7-aminodesacetoxycephalosporanic acid (I) by the reaction of the obtained mixture with tetramethylsilylchloride at 20 to 30°C for 20 to 24 hrs.

    Abstract translation: 目的：提供一种制备用作制备头孢菌素抗生素的重要中间体的7-氨基脱乙酸基头孢烷酸的方法，其包括在金属铟或铟化合物存在下3-取代头孢菌素衍生物的反应。 构成：一种方法包括通过3-取代头孢菌素衍生物（II）在有机溶剂和水的混合溶液中的反应制备7-氨基脱乙酸基头孢烷酸衍生物（I）和3-异二甲酰头孢烯衍生物（III）的混合物的步骤 在单独的铟金属或铟金属与金属碘化物的混合物的存在下，在10〜80℃下反应1〜10小时，并通过所得混合物与四甲基甲硅烷基氯反应，在20〜30℃下制备7-氨基脱乙酸基头孢烷酸（I） C为20至24小时。

    신규 Zn-DPA 착화합물 및 이를 포함하는 siRNA 전달시스템
    19.
    发明授权
    신규 Zn-DPA 착화합물 및 이를 포함하는 siRNA 전달시스템 有权
    Zn-DPA siRNA新的Zn-DPA复合物化合物和包含其的siRNA递送系统

    公开(公告)号：KR101824415B1

    公开(公告)日：2018-02-06

    申请号：KR1020160101150

    申请日：2016-08-09

    Applicant: 한국과학기술연구원

    Inventor： 금교창 ,  방은경 ,  김진범

    IPC: C07D401/12 ,  C07F3/06 ,  A61K48/00 ,  A61K47/18

    CPC classification number: C12N15/113 ,  C07D213/38 ,  C07D495/04 ,  C07F3/06 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2320/51 ,  C07D401/12 ,  A61K47/18 ,  A61K48/00 ,  A61K48/0008

    Abstract: 본발명은아연(Ⅱ)-다이피콜일아민(이하, Zn-DPA라함)의친인산기능부, 친세포막기능부및 상기친인산기능부와친세포막기능부를연결하는링커부로구성되는신규의 Zn-DPA 착화합물과, 상기 Zn-DPA 착화합물이수송체로포함되어있는 siRNA 전달시스템에관한것이다. 본발명의 Zn-DPA 착화합물은낮은독성을가지고있고, 효율적으로 siRNA를세포내로전달하므로 siRNA를이용한각종연구, 질병의진단및 치료에다방면으로이용이가능하다.

    Abstract translation: 本发明提供一种新的Zn-DPA复合化合物和包含其作为转运蛋白的siRNA递送系统，所述Zn-DPA络合化合物包括：锌（II） - 二甲苯胺（“Zn-DPA”）的磷酸盐导向功能部分 ; 细胞膜导向功能部分; 以及连接磷酸盐指导功能部分和细胞膜指导功能部分的连接部分。 Zn-DPA复合化合物具有低毒性并且有效地将siRNA递送至细胞，由此以各种方式用于使用siRNA的疾病的各种研究和诊断和治疗。

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