公开(公告)号：CA2532982A1

公开(公告)日：2005-02-03

申请号：CA2532982

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  HEYMAN HOWARD R ,  MUCKEY MELANIE A ,  HIRST GAVIN C ,  RAFFERTY PAUL ,  BETSCHMANN PATRICK ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  WADA CAROL K ,  FREY ROBIN R

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula: (I), are useful for inhibiting protein tyrosin e kinases. The present invention also discloses methods of making the compound s, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：CY1111599T1

公开(公告)日：2015-10-07

申请号：CY091100278

申请日：2009-03-12

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Ενώσειςπουέχουντονχημικότύπο: (I), είναιχρήσιμεςγιατηναναστολήκινασώντυροσίνηςπρωτεΐνης. Στηνπαρούσαεφεύρεσηαποκαλύπτονταικαιδημοσιοποιούνταιωςαναφοράεπίσηςμέθοδοιγιατηνπαρασκευήτωνενώσεων, τωνσυνθέσεωνπουπεριέχουντιςενώσεις, καιτωνμεθόδωναγωγήςχρησιμοποιώνταςτιςενώσεις.

公开(公告)号：NZ544712A

公开(公告)日：2009-09-25

申请号：NZ54471204

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Disclosed are compounds of formula (I) wherein: X is S; Z is C; R1 and R3 are as described in the specification; and R2 is hydrogen or alkyl. Compounds of the type disclosed are tyrosine kinase inhibitors useful in the treatment of cancer.

公开(公告)号：CA2620223A1

公开(公告)日：2007-03-08

申请号：CA2620223

申请日：2006-09-01

Applicant: ABBOTT LAB

Inventor： MORYTKO MICHAEL J ,  FRANK KRISTINE E ,  BETSCHMANN PATRICK ,  HIRST GAVIN C ,  CALDERWOOD DAVID J ,  DIXON RICHARD W ,  BREINLINGER ERIC C

IPC: A01N43/50

Abstract: The present invention is directed to novel imidazopyrazine and imidazopyrimidine compounds of formula (I), wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

公开(公告)号：BRPI0412894A

公开(公告)日：2006-10-03

申请号：BRPI0412894

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: A61P35/00 ,  C07D491/04 ,  C07D495/04 ,  C07D498/04 ,  A61K31/4355 ,  A61K31/4365

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：AU2004259765A1

公开(公告)日：2005-02-03

申请号：AU2004259765

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： HRNCIAR PETER ,  DAVIS HEATHER M ,  BURCHAT ANDREW F ,  WADA CAROL K ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  FREY ROBIN R ,  RAFFERTY PAUL ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  MUCKEY MELANIE A ,  DAVIDSEN STEVEN K ,  MICHAELIDES MICHAEL R ,  BETSCHMANN PATRICK

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：AU2009251083A1

公开(公告)日：2010-01-21

申请号：AU2009251083

申请日：2009-12-22

Applicant: ABBOTT LAB

Inventor： CALDERWOOD DAVID J ,  MUCKEY MELANIE A ,  FREY ROBIN R ,  CURTIN MICHAEL L ,  BETSCHMANN PATRICK ,  HEYMAN HOWARD R ,  MICHAELIDES MICHAEL R ,  WADA CAROL K ,  RAFFETY PAUL ,  HIRST GAVIN C ,  DAVIDSEN STEVEN K ,  HRNCIAR PETER ,  BURCHAT ANDREW F ,  DAVIS HEATHER M

IPC: A61P35/00 ,  C07D491/04 ,  C07D495/04 ,  C07D498/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：MX2009010362A

公开(公告)日：2009-10-16

申请号：MX2009010362

申请日：2008-03-27

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  CALDERWOOD DAVID J ,  DIXON RICHARD W ,  FRANK KRISTINE E ,  BREINLINGER ERIC C

IPC: A01N43/58 ,  A61K31/50 ,  C07D471/00

Abstract: La presente invención está dirigida a compuestos de imidazopirazina novedosos útiles como inhibidores de cinasa y podrían ser útiles en el tratamiento de ciertas condiciones y enfermedades, especialmente condiciones y enfermedades inflamatorias y trastornos y condiciones proliferativas, por ejemplo, cánceres.

公开(公告)号：DE602004018780D1

公开(公告)日：2009-02-12

申请号：DE602004018780

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：AT419253T

公开(公告)日：2009-01-15

申请号：AT04779180

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW ,  CALDERWOOD DAVID ,  CURTIN MICHAEL ,  DAVIDSEN STEVEN ,  DAVIS HEATHER ,  FREY ROBIN ,  HEYMAN HOWARD ,  HIRST GAVIN ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL ,  MUCKEY MELANIE ,  RAFFERTY PAUL ,  WADA CAROL

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.