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公开(公告)号：CA2407093A1
公开(公告)日：2001-11-01
申请号：CA2407093
申请日：2001-04-25
Applicant: ABBOTT LAB
Inventor： GWALTNEY STEPHEN L II , SULLIVAN GERALD M , WANG GARY T , FAKHOURY STEPHEN A , HUTCHINS CHARLES W , LI QUN , SHAM HING L , HASVOLD LISA A , WANG XILU , LIN NAN-HORNG , CURTIN MICHAEL L , WANG WEI-BO , O'CONNOR STEPHEN J , JENNINGS NELSON LISSA TAKA
IPC: C07D233/22 , A61K31/381 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4245 , A61K31/426 , A61K31/4406 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61P17/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D231/12 , C07D233/26 , C07D233/54 , C07D249/04 , C07D249/08 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/16 , C07D333/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/10 , C07D417/12 , A61K31/33 , C07D213/74 , C07D409/12
Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhib it farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
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公开(公告)号：AU5227999A
公开(公告)日：2000-02-21
申请号：AU5227999
申请日：1999-07-23
Applicant: ABBOTT LAB
Inventor： GWALTNEY STEPHEN L II , JAE HWAN-SOO , KALVIN DOUGLAS M , LIU GANG , SHAM HING L , LI QUN , CLAIBORNE AKIYO K , WANG LE , BARR KENNETH J , WOODS KEITH W
IPC: C07D263/10 , C07D263/14 , C07D413/04 , C07D471/04 , C07D473/04 , A61K31/421 , A61K31/422
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公开(公告)号：MY136181A
公开(公告)日：2008-08-29
申请号：MYPI20014939
申请日：2001-10-24
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TONGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: SUBSTITUTED IMIDAZOLES AND THIAZOLES HAVING THE FORMULA I ARE USEFUL FOR INHIBITING FARNESYLTRANSFERASE.ALSO DISCLOSED ARE FARNESYLTRANSFERASE-INHIBITING COMPOSITIONS AND METHODS OF INHIBITING FARNESYLTRANSFERASE IN A PATIENT .
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公开(公告)号：DK1339695T3
公开(公告)日：2006-07-31
申请号：DK01273519
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , LI TOMGMEI , MANTEI ROBERT A , ROCKWAY TODD W , TONG YUNSONG , WANG GARY T , WANG XILU , WANG WEIBO , HASVOLD LISA A , LI QUN , LIN NAN-HORNG , SHAM HING L , SULLIVAN GERARD M , WANG LE
IPC: C07D233/64 , A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：ES2215668T3
公开(公告)日：2004-10-16
申请号：ES00936388
申请日：2000-05-26
Applicant: ABBOTT LAB
Inventor： QUN LI , SHAM HING , STEINER BETH A , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
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Patent Agency Ranking
公开(公告)号：AT260248T
公开(公告)日：2004-03-15
申请号：AT00936388
申请日：2000-05-26
Applicant: ABBOTT LAB
Inventor： QUN LI , SHAM HING , STEINER BETH A , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL , WOODS KEITH W
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
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公开(公告)号：BR0112028A
公开(公告)日：2004-02-17
申请号：BR0112028
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：AU5921801A
公开(公告)日：2001-11-07
申请号：AU5921801
申请日：2001-04-25
Applicant: ABBOTT LAB
Inventor： WANG WEI-BO , CURTIN MICHAEL L , FAKHOURY STEPHEN A , GWALTNEY STEPHEN L II , HASVOLD LISA A , HUTCHINS CHARLES W , LI QUI , LIN NAN-HORNG , NELSON LISSA TAKA JENNINGS , O'CONNOR STEPHEN J , SHAM HING L , SULLIVAN GERALD M , WANG GARY T , WANG XILU
IPC: C07D233/22 , A61K31/381 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4245 , A61K31/426 , A61K31/4406 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61P17/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D231/12 , C07D233/26 , C07D233/54 , C07D249/04 , C07D249/08 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/16 , C07D333/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/10 , C07D417/12 , C07D233/00
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19.发明专利
公开(公告)号：SK286686B6
公开(公告)日：2009-03-05
申请号：SK8232003
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: C07D233/00 , A61K31/00 , A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/00 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Disclosed are substituted imidazoles and thiazoles having formula (I) useful for inhibiting farnesyltransferase and also disclosed are farnesyltransferase-inhibiting compositions and the use these compounds in the production of medicaments for inhibiting farnesyltransferase.
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公开(公告)号：ES2261340T3
公开(公告)日：2006-11-16
申请号：ES01273519
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Un compuesto de **fórmula** o una sal farmacéuticamente aceptable del mismo, donde E es un anillo carbocíclico, aromático o no aromático, de cinco, seis o siete miembros donde cero a tres átomos de carbono se reemplazan con nitrógeno; F y G se seleccionan independientemente entre el grupo constituido por C y N; con la condición de que cuando uno de F y G es N, el otro es C; cada uno de L1 y L2 se selecciona independientemente entre el grupo constituido por un enlace, alquenileno C2, alquinileno C2, O, NR9, C(O), S, S(O), SO2, SO2NR9, NR9SO2, C(O)NR9, NR9C(O) y CO2; X se selecciona entre el grupo constituido por S y NR7; R2 se selecciona entre el grupo constituido por hidrógeno, alcoxi, alquilo, amino, aminoalquilo, ciano, cianoalquilo, cicloalquilo, cicloalquilalquilo, halo, haloalquilo, heterociclo, (heterociclo)alquilo, hidroxi e hidroxialquilo; R3 se selecciona entre el grupo constituido por arilo, heterociclo y cicloalquilo; cada uno de R4-6 se selecciona independientemente entre el grupo constituido por hidrógeno, NR9C(O), C(O)NR9, alcanoílo, alquenilo, alcoxi, alcoxialquilo, alquilo, alquilsulfonilo, alquinilo, amido, amino, aminoalquilo, aminosulfonilo, arilo, arilalquilo, ariloxi, arilsulfonilo, azido, carboxi, ciano, cianoalquilo, cicloalquilo, cicloalquilalquilo, halo, haloalcoxi, haloalquilo, heterociclo, (heterociclo)alquilo, hidroxi, hidroxialquilo, nitro, nitroalquilo, oxo y tio(oxo); R7 se selecciona entre el grupo constituido por hidrógeno, alquilo, arilo, cicloalquilo, cicloalquilalquilo, heterociclo, (heterociclo) alquilo y trialquilsililo.
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