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公开(公告)号：AT294809T
公开(公告)日：2005-05-15
申请号：AT00942860
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：PT777655E
公开(公告)日：2001-06-29
申请号：PT95927566
申请日：1995-08-03
Applicant: ABBOTT LAB
Inventor： EHRLICH PAUL P , MICHAELIDES MICHAEL R , MCLAUGHLIN MAUREEN A , HSAIO CHI-NUNG
IPC: C07D221/18 , C07D491/04 , C07D491/048 , C07D495/04 , A61K31/47
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公开(公告)号：CA2375364A1
公开(公告)日：2000-12-28
申请号：CA2375364
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： MORTON HOWARD E , HAIGHT ANTHONY R , MCLAUGHLIN MAUREEN A , GRIEME TIM , RASMUSSEN MICHAEL , HSU MARGARET CHI-PING , KING STEVEN A , RILEY DAVID , WITTENBERGER STEVEN J , TIEN JIEN-HEH J , LEANNA MARVIN R , RAJE PRASAD S , HILL DAVID R , PLATA DANIEL J , DESHPANDE MAHENDRA N , COOPER ARTHUR J , KU YI-YIN , CINK RUSSELL D , LEE ELAINE C , PETERSON MATTHEW J , STONER ERIC J , NAPIER JAMES J
Abstract: In one aspect, the invention relates to a process for preparing 6-O- substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylatin g agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：PT1272500E
公开(公告)日：2005-09-30
申请号：PT00942860
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： COOPER ARTHUR J , HAIGHT ANTHONY R , KU YI-YIN , MORTON HOWARD E , PLATA DANIEL J , STONER ERIC J , PETERSON MATTHEW J , CINK RUSSELL D , DESHPANDE MAHENDRA N , TIM GRIEME , HILL DAVID R , CHI-PING HSU MARGARET , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , NAPIER JAMES J , RAJE PRASAD S , MICHAEL RASMUSSEN , DAVID RILEY , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
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公开(公告)号：DE60019976D1
公开(公告)日：2005-06-09
申请号：DE60019976
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN , WITTENBERGER
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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Patent Agency Ranking
公开(公告)号：DE69519864T2
公开(公告)日：2001-08-02
申请号：DE69519864
申请日：1995-08-03
Applicant: ABBOTT LAB
Inventor： EHRLICH PAUL P , MICHAELIDES MICHAEL R , MCLAUGHLIN MAUREEN A , HSAIO CHI-NUNG
IPC: C07D221/18 , C07D491/04 , C07D491/048 , C07D495/04 , A61K31/47
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公开(公告)号：GR3035606T3
公开(公告)日：2001-06-29
申请号：GR20010400452
申请日：2001-03-20
Applicant: ABBOTT LAB
Inventor： EHRLICH PAUL P , MICHAELIDES MICHAEL R , MCLAUGHLIN MAUREEN A , HSAIO CHI-NUNG
IPC: C07D221/18 , C07D491/04 , C07D491/048 , C07D495/04 , A61K31/47
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公开(公告)号：AT198592T
公开(公告)日：2001-01-15
申请号：AT95927566
申请日：1995-08-03
Applicant: ABBOTT LAB
Inventor： EHRLICH PAUL P , MICHAELIDES MICHAEL R , MCLAUGHLIN MAUREEN A , HSAIO CHI-NUNG
IPC: C07D221/18 , C07D491/04 , C07D491/048 , C07D495/04 , A61K31/47 , C07D221/00 , C07D307/00
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公开(公告)号：CA2195676A1
公开(公告)日：1996-02-29
申请号：CA2195676
申请日：1995-08-03
Applicant: ABBOTT LAB
Inventor： EHRLICH PAUL P , MICHAELIDES MICHAEL R , MCLAUGHLIN MAUREEN A , HSAIO CHI-NUNG
IPC: C07D221/18 , C07D491/04 , C07D491/048 , C07D495/04 , A61K31/47
Abstract: A process for preparing a chiral tetracyclic compound of formula (1), wherein R is hydrogen or a C1-C6-alkyl group and Z is oxygen, sulfur or -CH=CH-, the compounds having uses as dopamine agonists. The process involves reacting a chiral starting material and subsequent chiral intermediates in a series of chirality-preserving synthetic reactions.
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公开(公告)号：CA2705987A1
公开(公告)日：2009-05-28
申请号：CA2705987
申请日：2008-11-20
Applicant: ABBOTT LAB
Inventor： VON GELDERN THOMAS W , BURKALOW JUFANG H , BARNES DAVID M , HAIGHT ANGHONY R , HENGEVELD JOHN E , LI XIAOFENG , MCLAUGHLIN MAUREEN A , NOONAN WILLIAM T , PEI ZHONGHUA , WU-WONG JINSHYUN RUTH
IPC: C07C401/00
Abstract: The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
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