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公开(公告)号：ZA986828B
公开(公告)日：1999-01-29
申请号：ZA986828
申请日：1998-07-30
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE R , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C , C07D , A61K
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：ZA9818B
公开(公告)日：1998-07-02
申请号：ZA9818
申请日：1998-01-02
Applicant: ABBOTT LAB
Inventor： DAVIDSEN STEVEN K , SHEPPARD GEORGE S , XU LIANHONG , CURTIN MICHAEL L , WADA CAROL K , FLORJANCIC ALAN SCOTT , GIESLER JAMIE R , GUO YAN , MICHAELIDES MICHAEL R , HOLMS JAMES H
IPC: A61K31/165 , A61K31/197 , A61K31/381 , A61K31/404 , A61K31/4184 , A61K31/421 , A61K31/426 , A61K31/4406 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C233/32 , C07C259/06 , C07D207/32 , C07D207/323 , C07D207/335 , C07D209/14 , C07D213/50 , C07D235/14 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/22 , C07F , A61K , C07C
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公开(公告)号：CA2532982C
公开(公告)日：2013-11-26
申请号：CA2532982
申请日：2004-07-26
Applicant: ABBOTT LAB
Inventor： BETSCHMANN PATRICK , BURCHAT ANDREW F , CALDERWOOD DAVID J , CURTIN MICHAEL L , DAVIDSEN STEVEN K , DAVIS HEATHER M , FREY ROBIN R , HEYMAN HOWARD R , HIRST GAVIN C , HRNCIAR PETER , MICHAELIDES MICHAEL R , MUCKEY MELANIE A , RAFFERTY PAUL , WADA CAROL K
IPC: C07D495/04 , A61K31/4355 , A61K31/4365 , A61P35/00 , C07D491/04 , C07D498/04
Abstract: Compounds having the formula: (I), are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号：SI1648905T1
公开(公告)日：2009-06-30
申请号：SI200431056
申请日：2004-07-26
Applicant: ABBOTT LAB
Inventor： BETSCHMANN PATRICK , BURCHAT ANDREW F , CALDERWOOD DAVID J , CURTIN MICHAEL L , DAVIDSEN STEVEN K , DAVIS HEATHER M , FREY ROBIN R , HEYMAN HOWARD R , HIRST GAVIN C , HRNCIAR PETER , MICHAELIDES MICHAEL R , MUCKEY MELANIE A , RAFFERTY PAUL , WADA CAROL K
IPC: C07D495/00 , A61K31/00 , A61P35/00 , C07D491/00 , C07D491/04 , C07D495/04 , C07D498/00
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公开(公告)号：CA2294171C
公开(公告)日：2005-10-18
申请号：CA2294171
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： WADA CAROL K , DAVIDSEN STEVEN K , GIESLER JAMIE , XU LIANHONG , DELLARIA JOSEPH F JR , GONG JIANCHUN , FLORJANCIC ALAN S , GUO YAN , CURTIN MICHAEL L , MICHAELIDES MICHAEL R , HOLMS JAMES H , HEYMAN H ROBIN , STEINMAN DOUGLAS
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00 , C07D249/12 , A61K31/16 , A61K31/35 , A61K31/357 , C07D209/40 , A61K31/40 , A61K31/4164 , A61K31/42 , A61K31/44 , A61K31/445
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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Patent Agency Ranking
公开(公告)号：CA2532982A1
公开(公告)日：2005-02-03
申请号：CA2532982
申请日：2004-07-26
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DAVIS HEATHER M , HEYMAN HOWARD R , MUCKEY MELANIE A , HIRST GAVIN C , RAFFERTY PAUL , BETSCHMANN PATRICK , HRNCIAR PETER , MICHAELIDES MICHAEL R , BURCHAT ANDREW F , CALDERWOOD DAVID J , WADA CAROL K , FREY ROBIN R
IPC: C07D495/04 , A61K31/4355 , A61K31/4365 , A61P35/00 , C07D491/04 , C07D498/04
Abstract: Compounds having the formula: (I), are useful for inhibiting protein tyrosin e kinases. The present invention also discloses methods of making the compound s, compositions containing the compounds, and methods of treatment using the compounds.
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17.发明专利
公开(公告)号：BG64307B1
公开(公告)日：2004-09-30
申请号：BG10399599
申请日：1999-12-13
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00
Abstract: The compounds with the formula are inhibitors of matrix metallproteinases. The invention also relates to pharmaceutical compositions and methods for the inhibition of matrix metallproteinases in mammals. 18 claims
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公开(公告)号：SI1001930T1
公开(公告)日：2003-08-31
申请号：SI9830356
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07C259/00
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公开(公告)号：DK1001930T3
公开(公告)日：2003-03-24
申请号：DK98936014
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , GIESLER JAMIE , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , STEINMAN DOUGLAS H , WADA CAROL K , FLORJANCIC ALAN S , MICHAELIDES MICHAEL R , XU LIANHONG , GONG JIANCHUN
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：AT228998T
公开(公告)日：2002-12-15
申请号：AT98936014
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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