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公开(公告)号：AU2014206958B2
公开(公告)日：2017-08-10
申请号：AU2014206958
申请日：2014-01-15
Applicant: BASF SE
Inventor： BONNEKESSEL MELANIE , REICHERT WOLFGANG , HOOCK RALF , KAEDING THOMAS , KORADIN CHRISTOPHER , PLETSCH ANDREAS , EHRESMANN MANFRED , SCHRODER HARTWIG
IPC: C07D493/04 , A01N43/90
Abstract: The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11-trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor;and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i).
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公开(公告)号：CA2938583A1
公开(公告)日：2015-08-13
申请号：CA2938583
申请日：2015-02-06
Applicant: BASF SE
Inventor： KRAWCZYK JOANNA MARTYNA , HAEFNER STEFAN , SCHRODER HARTWIG , DANTAS COSTA ESTHER , ZELDER OSKAR , VON ABENDROTH GREGORY , WITTMANN CHRISTOPH , STELLMACHER RENE , BECKER JUDITH
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.
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公开(公告)号：CA2938231A1
公开(公告)日：2015-08-13
申请号：CA2938231
申请日：2015-02-02
Applicant: BASF SE
Inventor： KRAWCZYK JOANNA MARTYNA , HAEFNER STEFAN , SCHRODER HARTWIG , DANTAS COSTA ESTHER , ZELDER OSKAR , VON ABENDROTH GREGORY , WITTMANN CHRISTOPH , STELLMACHER RENE , BECKER JUDITH , LANGE ANNA , LYONS BENJAMIN J , LYONS THOMAS J , DE CRECY EUDES , HUGHES EWA
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
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公开(公告)号：AU2013349330A1
公开(公告)日：2015-06-04
申请号：AU2013349330
申请日：2013-11-13
Applicant: BASF SE
Inventor： ZELDER OSKAR , HOFF BIRGIT , SCHRODER HARTWIG , MOLT ANDREA , HARTMANN HOLGER , DITRICH KLAUS , BREUER MICHAEL , REINGRUBER RUDIGER , WEBER JAKOB
IPC: C12N15/11 , A01N37/00 , C07D307/77 , C12N15/63 , C12N15/67
Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
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公开(公告)号：AU2013307289A1
公开(公告)日：2015-02-19
申请号：AU2013307289
申请日：2013-08-13
Inventor： NAESBY MICHAEL , FOLLY CHRISTOPHE , NIELSEN CURT AIME FRIIS , HATSCH ANAELLE , SCHWAB MARKUS , ZELDER OSKAR , HAEFNER STEFAN , SCHRODER HARTWIG , HOFF BIRGIT , MOLT ANDREA , DITRICH KLAUS , BREUER MICHAEL , HARTMANN HOLGER , KORBER KARSTEN
IPC: C12N1/21 , A61K31/48 , C07K14/195 , C07K14/37 , C07K16/00 , C12N1/15 , C12N1/16 , C12N15/31 , C12N15/52 , C12N15/80 , C12N15/81 , C12P1/00 , C12P17/10
Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
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Patent Agency Ranking
公开(公告)号：AU2012222492A1
公开(公告)日：2013-08-29
申请号：AU2012222492
申请日：2012-02-24
Applicant: BASF SE
Inventor： SCHRODER HARTWIG , HOFF BIRGIT
IPC: A61K31/48
Abstract: The invention in principle pertains to the field of recombinant manufacture of alkaloids and, in particular, cycloclavine. It provides polynucleotides for the gene cluster of enzymes involved in the biosynthesis of cycloclavin as well as vectors and host cells comprising such polynucleotides. Also provided are polypeptides encoded by the said polynucleotides which can be applied in a method for the manufacture of cycloclavine also encompassed by the present invention.
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公开(公告)号：CA2898963C
公开(公告)日：2021-09-14
申请号：CA2898963
申请日：2014-03-03
Applicant: BASF SE
Inventor： ERNST BURKHARD , EHRESMANN MANFRED , KORADIN CHRISTOPHER , PLETSCH ANDREAS , BONNEKESSEL MELANIE , KAEDING THOMAS , SCHEIN-ALBRECHT KARIN , DEMMING STEFANIE , WEBER FRANZ , SIEGEL WOLFGANG , SCHRODER HARTWIG , FREYER STEPHAN , ODMAN PETER
IPC: C12P17/18
Abstract: The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula (III) and/or Formula (IV) and/or Formula (V) from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula (III) and/or Formula (IV) and/or Formula (V), including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula (IV) and/or Formula (V) in order to produce pest control compositions, in particular insecticides, comprising such compounds.
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公开(公告)号：AU2014242607A1
公开(公告)日：2015-08-06
申请号：AU2014242607
申请日：2014-03-03
Applicant: BASF SE
Inventor： ERNST BURKHARD , EHRESMANN MANFRED , KORADIN CHRISTOPHER , PLETSCH ANDREAS , BONNEKESSEL MELANIE , KAEDING THOMAS , SCHEIN-ALBRECHT KARIN , DEMMING STEFANIE , WEBER FRANZ , SIEGEL WOLFGANG , SCHRODER HARTWIG , FREYER STEPHAN , ODMAN PETER
IPC: C12P17/18
Abstract: The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula (III) and/or Formula (IV) and/or Formula (V) from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula (III) and/or Formula (IV) and/or Formula (V), including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula (IV) and/or Formula (V) in order to produce pest control compositions, in particular insecticides, comprising such compounds.
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公开(公告)号：CA2920814A1
公开(公告)日：2015-03-05
申请号：CA2920814
申请日：2014-08-18
Applicant: BASF SE
Inventor： KRAWCZYK JOANNA MARTYNA , HAEFNER STEFAN , SCHRODER HARTWIG , ZELDER OSKAR , FABARIUS JONATHAN THOMAS
Abstract: A modified microorganism having, compared to its wildtype, an increased activity of the enzyme that is encoded by the alaD-gene is provided. A method for producing an alanine and the use of modified microorganisms are also provided.
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公开(公告)号：CA2696666A1
公开(公告)日：2009-02-26
申请号：CA2696666
申请日：2008-08-14
Applicant: BASF SE
Inventor： SCHOLTEN EDZARD , DAEGELE DIRK , HAEFNER STEFAN , SCHRODER HARTWIG
Abstract: The present invention relates to a novel bacterial strain designated DD1, which has the ability to produce organic acids, in particular succinic acid (SA), which was originally isolated from bovine rumen, and is capable of utilizing glycerol as a carbon source; and variant strains derived there from retaining said capability; as well as to methods of producing organic acids, in particular succinic acid by making use of said microorganism.
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