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公开(公告)号：CA2720247A1
公开(公告)日：2009-12-03
申请号：CA2720247
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： EID JOHN , TURNER STEPHEN , DALAL RAVI , FLUSBERG BENJAMIN , KORLACH JONAS , LIN STEVEN , FEHR ADRIAN , CHRISTIANS FRED , EMIG ROBIN
Abstract: Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided.
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公开(公告)号：AU2009251881A1
公开(公告)日：2009-12-03
申请号：AU2009251881
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： CHRISTIANS FRED , KORLACH JONAS , DALAL RAVI , EID JOHN , LIN STEVEN , FEHR ADRIAN , EMIG ROBIN , FLUSBERG BENJAMIN , TURNER STEPHEN
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公开(公告)号：CA2720247C
公开(公告)日：2020-07-14
申请号：CA2720247
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： EID JOHN , TURNER STEPHEN , DALAL RAVI , FLUSBERG BENJAMIN , KORLACH JONAS , LIN STEVEN , FEHR ADRIAN , CHRISTIANS FRED , EMIG ROBIN
Abstract: Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided.
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公开(公告)号：AU2009251881B2
公开(公告)日：2015-03-26
申请号：AU2009251881
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： TURNER STEPHEN , CHRISTIANS FRED , FEHR ADRIAN , FLUSBERG BENJAMIN , EMIG ROBIN , DALAL RAVI , KORLACH JONAS , LIN STEVEN , EID JOHN
Abstract: Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided.
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公开(公告)号：AU2009251883A1
公开(公告)日：2009-12-03
申请号：AU2009251883
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： BJORNSON KEITH , EMIG ROBIN , PELUSO PAUL , HE MOLLY , CLARK SONYA , BIBILLO AREK , LEE HAROLD , JIA LEI , CHRISTIANS FRED , PARK INSIL
Abstract: Provided are compositions comprising modified recombinant polymerases that exhibit branching fractions that are less than the branching fractions of the polymerases from which they were derived, or branching fractions that are less than about 25% for a phosphate-labeled nucleotide analog. Also provided are compositions comprising modified recombinant polymerases that exhibit closed polymerase/DNA complexes with increased stability relative to the parental polymerase. Also provided are compositions comprising modified recombinant polymerases that exhibit decreased rate constants relative to the parental polymerases. Provided are methods for generating polymerases with the aforementioned phenotypes. Provided are methods of using such polymerases to make a DNA or to sequence a DNA template.
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Patent Agency Ranking
公开(公告)号：CA2714630A1
公开(公告)日：2009-08-13
申请号：CA2714630
申请日：2009-02-06
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： OTTO GEOFFREY , SHEN GENE , KONG XIANGXU , EMIG ROBIN
Abstract: The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.
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17.发明公开GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING 有权单分子测序法提高修饰聚合物的生成精度
公开(公告)号：EP2271751A4
公开(公告)日：2011-09-14
申请号：EP09755183
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： CLARK SONYA , BIBILLO AREK , PELUSO PAUL , CHRISTIANS FRED , HE MOLLY , PARK INSIL , LEE HAROLD , BJORNSON KEITH , JIA LEI , EMIG ROBIN
CPC classification number: C12N9/1252 , C12Q1/6844 , C12Q1/6869 , C12Q2521/101
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18.发明公开INTERMITTENT DETECTION DURING ANALYTICAL REACTIONS 有权INTERMITTIERENDE DETEKTIONWÄHRENDANALYSEREAKENEN
公开(公告)号：EP2331935A4
公开(公告)日：2012-04-18
申请号：EP09816557
申请日：2009-09-16
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： MAXHAM KENNETH MARK , SORENSON JON , EID JOHN , MARKS PATRICK , TRAVERS KEVIN , GRAY DONALD , EMIG ROBIN , CHAISSON MARK , FLUSBERG BENJAMIN
CPC classification number: C12Q1/6869 , G01N2021/7786 , Y10T436/143333 , C12Q2525/301 , C12Q2533/101 , C12Q2537/149 , C12Q2565/631 , C12Q2525/307 , C12Q2525/191
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19.发明专利
公开(公告)号：ES2614078T3
公开(公告)日：2017-05-29
申请号：ES15168606
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： CLARK SONYA , BIBILLO AREK , PELUSO PAUL , CHRISTIANS FRED , HE MOLLY , PARK INSIL , LEE HAROLD , BJORNSON KEITH , JIA LEI , EMIG ROBIN
Abstract: Una composición que comprende una ADN polimerasa recombinante, ADN polimerasa recombinante que comprende una secuencia de aminoácidos que es al menos el 80 % idéntica a la SEQ ID NO: 1, ADN polimerasa recombinante que comprende un resto de ácido glutámico, un resto de ácido aspártico, un resto de histidina, un resto de lisina, un resto de arginina o un resto de tirosina en la posición A484, en la que la identificación de las posiciones es con respecto a la SEQ ID NO: 1, y ADN polimerasa recombinante que muestra actividad polimerasa.
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公开(公告)号：AU2009251883B2
公开(公告)日：2014-09-11
申请号：AU2009251883
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： JIA LEI , BJORNSON KEITH , PARK INSIL , CLARK SONYA , CHRISTIANS FRED , EMIG ROBIN , HE MOLLY , PELUSO PAUL , LEE HAROLD , BIBILLO AREK
Abstract: Provided are compositions comprising modified recombinant polymerases that exhibit branching fractions that are less than the branching fractions of the polymerases from which they were derived, or branching fractions that are less than about 25% for a phosphate-labeled nucleotide analog. Also provided are compositions comprising modified recombinant polymerases that exhibit closed polymerase/DNA complexes with increased stability relative to the parental polymerases. Also provided are compositions comprising modified recombinant polymerases that exhibit decreased rate constants relative to the parental polymerases. Provided are methods for generating polymerases with the aforementioned phenotypes. Provided are methods of using such polymerases to make a DNA or to sequence a DNA template.
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