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公开(公告)号：CR10473A
公开(公告)日：2009-01-12
申请号：CR10473
申请日：2008-11-28
Applicant: ABBOTT LAB
Inventor： DART MICHAEL J , CARROL WILLIAM A , FLORJANCIC ALAN S , FROST JENNIFER M , GALLAGHER MEGAN E , LI TONGMEI , NELSON DEREK W , PATEL MEENA V , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , RYTHER KEITH B , TIETJE KARIN ROSEMARIE , KOLASA TEODOZYJ
IPC: A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , A61P29/00 , C07D277/46 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: Compuestos de la formula (I), o sales farmaceuticas, prodrogas, sales de prodrogas, o combinaciones de los mismos, donde R1, R2, R3, R4 y L1 se definen en la memoria descriptiva, composiciones que comprenden dichos compuestos, y metodos para tratar condiciones y trastornos usando dichos compuestos y composiciones. La presente invencion tambien se refiere a compuestos de formula (II) o sales farmaceuticas, prodrogas, sales de prodrogas, o combinaciones de los mismos, donde R1a, R2a y Rxn tienen los valores definidos en la memoria descriptiva, composiciones que comprenden dichos compuestos, y metodos para tratar condiciones y trastornos usando dichos compuestos y composiciones.
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公开(公告)号：NO20085385L
公开(公告)日：2008-12-29
申请号：NO20085385
申请日：2008-12-29
Applicant: ABBOTT LAB
Inventor： RYTHER KEITH B , KOLASA TEODOZYJ , PATEL MEENA V , DART MICHAEL J , CARROLL WILLIAM A , FLORJANCIC ALAN S , FROST JENNIFER M , GALLAGHER MEGAN E , LI TONGMEI , NELSON DEREK W , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , TIETJE KARIN ROSEMARIE
IPC: C07D277/28
Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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公开(公告)号：AT394401T
公开(公告)日：2008-05-15
申请号：AT03017562
申请日：2000-01-25
Applicant: ABBOTT LAB
Inventor： BUNNELLE WILLIAM H , BARLOCCO CRISTINA DANIELA , DAANEN JEROME F , DART MICHAEL J , MEYER MICHAEL D , RYTHER KEITH B , SCHRIMPF MICHAEL R , SIPPY KEVIN B , TOUPENCE RICHARD B
IPC: C07D487/08 , A61K31/00 , A61K31/395 , A61K31/407 , A61K31/4355 , A61K31/4365 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/502 , A61P9/10 , A61P15/10 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D401/08 , C07D471/08 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.
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公开(公告)号：CA2592378A1
公开(公告)日：2006-06-29
申请号：CA2592378
申请日：2005-12-21
Applicant: ABBOTT LAB
Inventor： FROST JENNIFER M , TIETJE KARIN , DART MICHAEL J , MEYER MICHAEL D
IPC: C07D417/06 , A61K31/404 , A61K31/422 , A61K31/428 , A61K31/435 , A61K31/454 , A61K31/496 , A61K31/55 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06
Abstract: The present invention provides novel compounds of Formula (I) which are CB2 selective ligands useful for the treatment of pain.
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公开(公告)号：CA2502906A1
公开(公告)日：2004-05-06
申请号：CA2502906
申请日：2003-10-22
Applicant: ABBOTT LAB
Inventor： BUNNELLE WILLIAM H , CHANG SOU-JEN , DART MICHAEL J , FERNANADO DILINIE P , CHEMBURKAR SANJAY R , BENNANI YOUSSEF L , LOCKWOOD MARK , WANG LEI , KU YI-YIN , CHEN JINHUA
IPC: A61P25/00 , A61P29/00 , C07C61/13 , C07C61/135 , C07C69/753 , C07C233/58 , C07C233/60 , C07C233/63 , A61K31/16 , A61K31/19 , C07C61/00 , C07C229/00 , C07C233/00
Abstract: The present invention relates to the use of compounds of Formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.
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Patent Agency Ranking
公开(公告)号：BG64196B1
公开(公告)日：2004-04-30
申请号：BG10355699
申请日：1999-07-06
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT S , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The invention relates to a method for pain control in mammals, including humans where selected compounds are applied with the formula or their pharmaceutically acceptable salts, the meaning of the substituents being listed in the description. The invention also relates to selected (R) and (S) compounds with formula I which can be used as analgetics, as means for the prevention of dying of neuron cells and as antiphlogistic preparations. 39 claims, 6 figures
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公开(公告)号：DK1147112T3
公开(公告)日：2004-02-23
申请号：DK00906998
申请日：2000-01-25
Applicant: ABBOTT LAB
Inventor： BUNNELLE WILLIAM H , CRISTINA DANIELA BARLOCCO , DAANEN JEROME F , DART MICHAEL J , MEYER MICHAEL D , RYTHER KEITH B , SCHRIMPF MICHAEL R , SIPPY KEVIN B , TOUPENCE RICHARD B
IPC: A61K31/00 , A61K31/407 , A61K31/4355 , A61K31/4365 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/502 , A61P9/10 , A61P15/10 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/048 , C07D495/04 , C07D519/00 , A61K31/395
Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.
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公开(公告)号：AT253067T
公开(公告)日：2003-11-15
申请号：AT00906998
申请日：2000-01-25
Applicant: ABBOTT LAB
Inventor： BUNNELLE WILLIAM H , CRISTINA DANIELA BARLOCCO , DAANEN JEROME F , DART MICHAEL J , MEYER MICHAEL D , RYTHER KEITH B , SCHRIMPF MICHAEL R , SIPPY KEVIN B , TOUPENCE RICHARD B
IPC: A61K31/00 , A61K31/407 , A61K31/4355 , A61K31/4365 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/502 , A61P9/10 , A61P15/10 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/048 , C07D495/04 , C07D519/00 , A61K31/395 , C07D209/00
Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.
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公开(公告)号：AT227717T
公开(公告)日：2002-11-15
申请号：AT97952392
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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公开(公告)号：HK1043116A1
公开(公告)日：2002-09-06
申请号：HK02102948
申请日：2002-04-18
Applicant: ABBOTT LAB
Inventor： BUNNELLE WILLIAM H , CRISTINA DANIELA BARLOCCO , DAANEN JEROME F , DART MICHAEL J , MEYER MICHAEL D , RYTHER KEITH B , SCHRIMPF MICHAEL R , SIPPY KEVIN B , TOUPENCE RICHARD B
IPC: A61K31/00 , A61K31/407 , A61K31/4355 , A61K31/4365 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/502 , A61P9/10 , A61P15/10 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/048 , C07D495/04 , C07D519/00 , C07D , A61K , A61P
Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.
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