公开(公告)号：DK0588917T3

公开(公告)日：2001-02-12

申请号：DK92912971

申请日：1992-05-28

Applicant: ABBOTT LAB

Inventor： SHUE YOUE-KONG ,  GARVEY DAVID S ,  CARRERA GEORGE M JR ,  ARNERIC STEPHEN P ,  LIN NAN-HORNG ,  HE YUN

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/422 ,  A61K31/425 ,  A61K31/427 ,  A61K31/44 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.

公开(公告)号：AT197454T

公开(公告)日：2000-11-11

申请号：AT92912971

申请日：1992-05-28

Applicant: ABBOTT LAB

Inventor： GARVEY DAVID S ,  CARRERA GEORGE M JR ,  ARNERIC STEPHEN P ,  SHUE YOUE-KONG ,  LIN NAN-HORNG ,  HE YUN

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/422 ,  A61K31/425 ,  A61K31/427 ,  A61K31/44 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.

公开(公告)号：AU6318898A

公开(公告)日：1998-09-09

申请号：AU6318898

申请日：1998-02-05

Applicant: ABBOTT LAB

Inventor： WASICAK JAMES T ,  GARVEY DAVID S ,  HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/44

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：AU2044495A

公开(公告)日：1996-08-01

申请号：AU2044495

申请日：1995-06-01

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  BAKER WILLIAM R ,  FUNG ANTHONY K L ,  ROSENBERG SAUL H ,  ROCKWAY TODD W ,  FAKHOURY STEPHEN A ,  GARVEY DAVID S ,  DONNER B GREGORY ,  MCCLELLAN WILLIAM J ,  O'CONNOR STEPHEN J ,  PRASAD RAJNANDAN ,  SHEN WANG ,  SULLIVAN GERARD M

IPC: A61K31/19 ,  C07C20060101 ,  C07C69/74 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C233/62 ,  C07C233/63 ,  C07C323/40 ,  C07D207/32 ,  C07D211/16 ,  C07D211/70 ,  C07D217/16 ,  C07D277/34 ,  C07D307/58 ,  C07D307/91 ,  C07D317/64 ,  C07D333/32

公开(公告)号：AU5355794A

公开(公告)日：1994-05-09

申请号：AU5355794

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  GARVEY DAVID S ,  LEBOLD SUZANNE A ,  WASICAK JAMES T

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  A61K31/425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：MX9306274A

公开(公告)日：1994-04-29

申请号：MX9306274

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： ELLIOTT RICHARD L ,  LEBOLD SUZANNE A ,  WASICAK JAMES T ,  GARVEY DAVID S ,  ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG

IPC: C07D403/12

公开(公告)号：ES2196548T3

公开(公告)日：2003-12-16

申请号：ES98907359

申请日：1998-02-05

Applicant: ABBOTT LAB

Inventor： WASICAK JAMES T ,  GARVEY DAVID S ,  HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/44

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：AT237618T

公开(公告)日：2003-05-15

申请号：AT98907359

申请日：1998-02-05

Applicant: ABBOTT LAB

Inventor： WASICAK JAMES T ,  GARVEY DAVID S ,  HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/44 ,  C07D209/00

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：PT663912E

公开(公告)日：2002-06-28

申请号：PT93923826

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： GARVEY DAVID S ,  ABREO MELWYN A ,  LIN NAN-HORNG ,  WASICAK JAMES T ,  LEBOLD SUZANNE A ,  ELLIOTT RICHARD L ,  GUNN DAVID E

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  A61K31/425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  C07D453/02

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：AT210656T

公开(公告)日：2001-12-15

申请号：AT93923826

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  GARVEY DAVID S ,  LEBOLD SUZANNE A ,  WASICAK JAMES T

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  A61K31/425 ,  A61K31/445 ,  A61K31/495

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.