公开(公告)号：TR9902550T2

公开(公告)日：2000-04-21

申请号：TR9902550

申请日：1998-04-13

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  PERNER RICHARD J ,  GU YU GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/505

CPC classification number: C07D471/04

公开(公告)号：TR199902550T2

公开(公告)日：2000-04-21

申请号：TR9902550

申请日：1998-04-13

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  PERNER RICHARD J ,  GU YU GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/505

Abstract: A compound having formula (II) wherein R , R , R , R and R are defined, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, pain, nociperception, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods for preparation thereof.

公开(公告)号：CA2641673A1

公开(公告)日：2007-08-23

申请号：CA2641673

申请日：2007-02-15

Applicant: ABBOTT LAB

Inventor： GU YU GUI ,  SHAM HING L ,  KEYES ROBERT F

IPC: C07D277/68 ,  A61K31/428 ,  A61P3/10 ,  C07D417/12

Abstract: The present invention relates to compounds of formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

公开(公告)号：BR0010525A

公开(公告)日：2002-11-26

申请号：BR0010525

申请日：2000-09-22

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN ,  GU YU GUI ,  HANESSIAN STEPHEN ,  STEWART KENT D ,  WANG GARY T ,  WANG JIANCHIO ,  MADIGAN DAROLD L

IPC: A61K31/16 ,  A61K31/19 ,  C07C233/52 ,  C07C247/12 ,  C07D303/38

公开(公告)号：AU741033B2

公开(公告)日：2001-11-22

申请号：AU7108098

申请日：1998-04-13

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  PERNER RICHARD J ,  GU YU GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/505

Abstract: A compound having formula (II) wherein R , R , R , R and R are defined, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, pain, nociperception, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods for preparation thereof.

公开(公告)号：SK140099A3

公开(公告)日：2000-05-16

申请号：SK140099

申请日：1998-04-13

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  PERNER RICHARD J ,  GU YU GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/505

Abstract: A compound having formula (II) wherein R , R , R , R and R are defined, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, pain, nociperception, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods for preparation thereof.

公开(公告)号：CZ9903508A3

公开(公告)日：2000-04-12

申请号：CZ350899

申请日：1998-04-13

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  PARNER RICHARD J ,  GU YU GUI

IPC: A61K31/505 ,  A61P9/00 ,  A61P25/08 ,  C07D471/04

公开(公告)号：BR0010555A

公开(公告)日：2003-09-23

申请号：BR0010555

申请日：2000-10-10

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN ,  GU YU GUI ,  HANESSIAN STEPHEN ,  WANG GARY T ,  KRUEGER ALLAN C ,  CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KENNEDY APRIL L ,  KLEIN LARRY L ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  TU NOAH P ,  WAGENAAR FRANK L ,  WANG SHELDON ,  WIEDEMAN PAUL E ,  XU YIBO ,  YEUNG MING C ,  BAYRAKDARIAN MALKEN ,  LUO XUEHONG

IPC: C07D401/12 ,  A61K31/357 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4025 ,  A61K31/405 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/42 ,  A61K31/422 ,  A61K31/425 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/66 ,  A61K31/662 ,  A61P31/00 ,  A61P31/12 ,  A61P31/16 ,  A61P43/00 ,  C07D20060101 ,  C07D207/00 ,  C07D207/12 ,  C07D207/16 ,  C07D207/26 ,  C07D207/32 ,  C07D207/327 ,  C07D207/38 ,  C07D207/46 ,  C07D303/16 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D407/06 ,  C07D407/12 ,  C07D409/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/40 ,  C07F9/572

公开(公告)号：AU7608100A

公开(公告)日：2001-04-30

申请号：AU7608100

申请日：2000-09-22

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN ,  GU YU GUI ,  HANESSIAN STEPHEN ,  STEWART KENT D ,  WANG GARY T ,  WANG JIANCHIO ,  MADIGAN DAROLD L

IPC: A61K31/16 ,  A61K31/19 ,  C07C233/52 ,  C07C247/12 ,  C07D303/38