Patent search ap:("ABBOTT LAB") AND inv:"LIN ZHEN" Page 1

1.

发明申请
PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES 审中-公开
Title translation: 吡咯啉衍生物，其制备及其作为神经酰胺酶抑制剂的用途

公开(公告)号：WO0128996A3

公开(公告)日：2001-11-29

申请号：PCT/US0027910

申请日：2000-10-10

Applicant: ABBOTT LAB , MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , HANESSIAN STEPHEN , WANG GARY T , KRUEGER ALLAN C , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , KATI WARREN M , KENNEDY APRIL L , KLEIN LARRY L , LIN ZHEN , MADIGAN DAROLD L

Inventor： MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , HANESSIAN STEPHEN , WANG GARY T , KRUEGER ALLAN C , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , KATI WARREN M , KENNEDY APRIL L , KLEIN LARRY L , LIN ZHEN , MADIGAN DAROLD L

IPC: C07D401/12 , A61K31/357 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/405 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K31/66 , A61K31/662 , A61P31/00 , A61P31/12 , A61P31/16 , A61P43/00 , C07D20060101 , C07D207/00 , C07D207/12 , C07D207/16 , C07D207/26 , C07D207/32 , C07D207/327 , C07D207/38 , C07D207/46 , C07D303/16 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D407/06 , C07D407/12 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/40 , C07F9/572

CPC classification number: C07D207/16 , C07D207/26 , C07D207/327 , C07D207/38 , C07D207/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/16 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06

Abstract: Enantiomerically enriched compounds having the absolute stereochemistry of the formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

2.

发明申请
INHIBITORS OF NEURAMINIDASES 审中-公开
Title translation: 神经酰胺酶抑制剂

公开(公告)号：WO0128979A3

公开(公告)日：2001-12-27

申请号：PCT/US0027938

申请日：2000-10-10

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , WANG GARY T , KRUEGER ALLAN C , CHEN YUANWEI , DEGOEY DAVID A , GRAMPOVNIK DAVID J , KATI WARREN M , KENNEDY APRIL L , LIN ZHEN , MADIGAN DONALD L , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , WANG SHELDON , YEUNG MING C

IPC: A61K31/195 , C07C233/48 , C07C237/24 , C07C271/22 , C07C271/24 , C07C279/16 , C07D233/54 , C07D263/32 , C07D307/24 , C07D317/30 , C07D405/04 , A61K31/325 , A61K31/34 , A61K31/415 , A61K31/42 , A61P31/00

CPC classification number: C07D233/64 , C07B2200/07 , C07B2200/09 , C07C233/48 , C07C237/24 , C07C271/22 , C07C271/24 , C07C279/16 , C07C2601/08 , C07C2601/10 , C07D263/32 , C07D307/24 , C07D317/30 , C07D405/04

Abstract: Disclosed are compounds of formula (I), (II) or (III) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

Abstract translation: 公开了可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶的式（I），（II）或（III）的化合物。还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。