公开(公告)号：NO995035A

公开(公告)日：1999-12-15

申请号：NO995035

申请日：1999-10-15

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/505

CPC classification number: C07D471/04

公开(公告)号：AU7098198A

公开(公告)日：1998-11-11

申请号：AU7098198

申请日：1998-04-16

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  LEE CHIH-HUNG ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/10 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/505

Abstract: A compound having formula (I), wherein R , R , R and R are defined variables selected from the groups as specified herein which include alkyl, aryl, heteroaryl and heterocyclic and substituted versions thereof, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, nociperception, pain, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods of preparation thereof.

公开(公告)号：CA2287465A1

公开(公告)日：1998-10-22

申请号：CA2287465

申请日：1998-04-16

Applicant: ABBOTT LAB

Inventor： LEE CHIH-HUNG ,  BHAGWAT SHRIPAD S ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/10 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/505

Abstract: A compound having formula (I), wherein R1, R2, R3 and R4 are defined variables selected from the groups as specified herein which include alkyl, aryl, heteroaryl and heterocyclic and substituted versions thereof, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, nociperception, pain, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods of preparation thereof.

公开(公告)号：ZA9803175B

公开(公告)日：1998-10-21

申请号：ZA9803175

申请日：1998-04-15

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  C07D ,  A61K

CPC classification number: C07D471/04

公开(公告)号：AU744528B2

公开(公告)日：2002-02-28

申请号：AU7098198

申请日：1998-04-16

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  LEE CHIH-HUNG ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/10 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/505

Abstract: A compound having formula (I), wherein R , R , R and R are defined variables selected from the groups as specified herein which include alkyl, aryl, heteroaryl and heterocyclic and substituted versions thereof, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, nociperception, pain, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods of preparation thereof.

公开(公告)号：NZ337844A

公开(公告)日：2001-11-30

申请号：NZ33784498

申请日：1998-04-16

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  LEE CHIH-HUNG ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/10 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/505

Abstract: Compounds of formula (I) wherein, R1 and R2 are independently selected from hydrogen and loweralkyl; R3 is selected from alkenyl, alkyl, alkynyl, aryl, arylalkyl and heterocycle; and R4 is selected from aryl and heterocycle; wherein each of the foregoing aryl, heterocycle, and aryl part of the arylalkyl is unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of F, Cl, Br, I, cyano, carboxamido, hydroxy, loweralkoxy, loweralkyl, loweralkenyl, loweralkynyl, amino, loweralkylamino, di(loweralkyl)amino, N-loweralkyl-N-loweralkoxyamino, trifluoromethyl, and methoxymethyl. The compounds act to inhibit adenosine kinase and are useful in treating ischemia, neurological disorders, nociperception, inflammation, immunosuppression, gastrointestinal disfunctions, diabetes and sepsis.

公开(公告)号：PL343678A1

公开(公告)日：2001-08-27

申请号：PL34367899

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40 ,  C07D407/04

公开(公告)号：BG104962A

公开(公告)日：2001-07-31

申请号：BG10496200

申请日：2000-11-17

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-JU ,  CHEN YCANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40 ,  C07D407/04

Abstract: Disclosed are compounds of formula which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminodase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes. 56 claims

公开(公告)号：NO995033L

公开(公告)日：1999-12-15

申请号：NO995033

申请日：1999-10-15

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  LEE CHIH-HUNG ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/10 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/505

Abstract: A compound having formula (I), wherein R , R , R and R are defined variables selected from the groups as specified herein which include alkyl, aryl, heteroaryl and heterocyclic and substituted versions thereof, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, nociperception, pain, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods of preparation thereof.

公开(公告)号：NO995033A

公开(公告)日：1999-12-15

申请号：NO995033

申请日：1999-10-15

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  LEE CHIH-HUNG ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/10 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/505

CPC classification number: C07D471/04