公开(公告)号：CA2518443A1

公开(公告)日：2004-09-30

申请号：CA2518443

申请日：2003-03-12

Applicant: ABBOTT LAB

Inventor： HANSEN TODD MATTHEW ,  TUFANO MICHAEL ,  CLARK RICHARD ,  WAGNER ROLF ,  HINMAN MIRA ,  LARSON DANIEL P ,  WEITZBERG MOSHE ,  KALVIN DOUGLAS ,  SANDERS WILLIAM ,  BOSSE TODD D ,  ROSENBERG TERESA ,  DANDLIKER PETER ,  MOTTER CHRISTOPHER ,  MA ZHENKUN ,  ANDERSON DAVID ,  PALAZZO FABIO ,  DAVID CAROLINE ,  COOPER CURT ,  BEUTEL BRUCE ,  GU YU-GUI ,  REHM TAMARA ,  LYNCH LINDA ,  YONG HONG ,  ZHANG TIANYUAN

IPC: A61P31/04 ,  C07D471/04 ,  A61K31/435

Abstract: Antibacterials having formula (I), and salts, prodrugs, and salts of prodrug s thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：NO20005301L

公开(公告)日：2000-12-08

申请号：NO20005301

申请日：2000-10-20

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40

公开(公告)号：CZ20003872A3

公开(公告)日：2001-03-14

申请号：CZ20003872

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-YU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/40 ,  A61P31/16 ,  C07D207/16 ,  C07D401/12 ,  C07D403/04 ,  C07D407/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04

公开(公告)号：BR9909870A

公开(公告)日：2000-12-19

申请号：BR9909870

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40 ,  C07D407/04

公开(公告)号：TR9902456T2

公开(公告)日：2000-07-21

申请号：TR9902456

申请日：1998-04-16

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  LEE CHIH-HUNG ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/10 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/505

CPC classification number: C07D471/04

公开(公告)号：CA2329660A1

公开(公告)日：1999-10-28

申请号：CA2329660

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  SUN MINGHUA ,  SHAM HING L ,  ZHAO CHEN ,  CHEN YUANWEI ,  WANG GARY T ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KENNEDY APRIL ,  YEUNG MING ,  MUCHMORE STEVEN W ,  MADIGAN DAROLD L ,  LIN ZHEN ,  STEWART KENT D ,  GU YU-GUI ,  WANG SHELDON ,  STOLL VINCENT S ,  MARING CLARENCE J ,  KEMPF DALE J ,  KATI WARREN M

IPC: A61K31/196 ,  A61K31/215 ,  A61K31/341 ,  A61K31/4164 ,  A61K31/421 ,  A61P31/16 ,  A61P43/00 ,  C07C233/47 ,  C07C233/52 ,  C07C237/24 ,  C07C271/22 ,  C07C271/24 ,  C07D233/54 ,  C07D263/32 ,  C07D307/24 ,  C07D317/32 ,  C07D405/04 ,  C07D493/08 ,  A61K31/16 ,  A61K31/33

Abstract: Disclosed are compounds of formula (I), (II) or (III), which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

公开(公告)号：NO995035D0

公开(公告)日：1999-10-15

申请号：NO995035

申请日：1999-10-15

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  C07D

Abstract: A compound having formula (II) wherein R , R , R , R and R are defined, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, pain, nociperception, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods for preparation thereof.

公开(公告)号：NO995033D0

公开(公告)日：1999-10-15

申请号：NO995033

申请日：1999-10-15

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  LEE CHIH-HUNG ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/10 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  C07D

Abstract: A compound having formula (I), wherein R , R , R and R are defined variables selected from the groups as specified herein which include alkyl, aryl, heteroaryl and heterocyclic and substituted versions thereof, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, nociperception, pain, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods of preparation thereof.

公开(公告)号：ZA982912B

公开(公告)日：1998-10-09

申请号：ZA982912

申请日：1998-04-06

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  LEE CHIH-HUNG ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/10 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  C07D ,  A61K

Abstract: A compound having formula (I), wherein R , R , R and R are defined variables selected from the groups as specified herein which include alkyl, aryl, heteroaryl and heterocyclic and substituted versions thereof, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, nociperception, pain, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods of preparation thereof.

公开(公告)号：HU0101224A2

公开(公告)日：2001-08-28

申请号：HU0101224

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  GU YU-GUI ,  KATI WARREN M ,  KEMPF DALE J ,  KENNEDY APRIL ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MARING CLARENCE J ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572