公开(公告)号：AU2003231801A8

公开(公告)日：2003-12-12

申请号：AU2003231801

申请日：2003-05-19

Applicant: ABBOTT LAB

Inventor： ZHANG HENRY Q ,  KOLASA TEODOZYJ ,  PATEL MEENA V ,  MATULENKO MARK A ,  XIA ZHIREN ,  STEWART ANDREW O ,  BHATIA PRAMILA A ,  WANG XUEQING ,  MORTELL KATHLEEN H ,  DAANEN JEROME F ,  HAKEEM AHMED A

IPC: C07D295/12 ,  A61K31/00 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/427 ,  A61K31/4418 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61P9/00 ,  A61P15/00 ,  A61P15/10 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P29/00 ,  C07D207/06 ,  C07D211/34 ,  C07D211/68 ,  C07D213/74 ,  C07D213/82 ,  C07D213/85 ,  C07D213/89 ,  C07D235/30 ,  C07D239/42 ,  C07D277/20 ,  C07D277/42 ,  C07D277/82 ,  C07D295/14 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04

公开(公告)号：CA2391291A1

公开(公告)日：2001-05-25

申请号：CA2391291

申请日：2000-11-17

Applicant: ABBOTT LAB

Inventor： YI LIN ,  ZHANG HENRY Q ,  CARROLL WILLIAM A ,  HOLLADAY MARK W ,  DRIZIN IRENE

IPC: A61K31/519 ,  A61P1/04 ,  A61P1/14 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  A61P13/10 ,  A61P13/12 ,  A61P15/00 ,  A61P15/06 ,  A61P15/08 ,  A61P15/10 ,  A61P17/14 ,  A61P25/08 ,  A61P25/28 ,  A61P29/00 ,  C07D487/04 ,  C07D491/14 ,  C07D495/14 ,  A61K31/505 ,  C07D231/00 ,  C07D239/00 ,  C07D307/00 ,  C07D335/00

Abstract: Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：BG104594A

公开(公告)日：2001-03-30

申请号：BG10459400

申请日：2000-07-11

Applicant: ABBOTT LAB

Inventor： CARROL WILLIAM A ,  HOLLADAY MARK W ,  SULLIVAN JAMES P ,  DRIZIN IRENE ,  ZHANG HENRY Q

IPC: A61K31/4365 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/00 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  C07C45/29 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14 ,  C07D211/84 ,  A61K31/44 ,  A61K31/38

Abstract: Compounds having the formula are useful in treating diseases prevented by the ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal. 41 claims

公开(公告)号：CA2375282A1

公开(公告)日：2000-12-28

申请号：CA2375282

申请日：2000-06-23

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  ZHANG HENRY Q ,  SULLIVAN JAMES P ,  YI LIN ,  TANG RUI ,  KYM PHILIP R ,  KORT MICHAEL E ,  HOLLADAY MARK W ,  CHEN YIYUAN

IPC: A61K31/4365 ,  A61K31/44 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/00 ,  A61P13/02 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10 ,  A61P25/00 ,  A61P25/06 ,  A61P25/08 ,  A61P43/00 ,  C07C45/00 ,  C07C45/29 ,  C07C45/41 ,  C07C45/63 ,  C07C45/71 ,  C07C205/44 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14 ,  C07D221/00 ,  C07D333/00 ,  C07D335/00 ,  C07D337/00

Abstract: Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：NO20003104L

公开(公告)日：2000-08-17

申请号：NO20003104

申请日：2000-06-16

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  HOLLADAY MARK W ,  SULLIVAN JAMES P ,  DRIZIN IRENE ,  ZHANG HENRY Q

IPC: A61K31/4365 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/00 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  C07C45/29 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14 ,  C07D211/84 ,  A61K31/44

Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：CA2647592C

公开(公告)日：2014-01-28

申请号：CA2647592

申请日：2007-05-24

Applicant: ABBOTT LAB

Inventor： DIEBOLD ROBERT B ,  DJURIC STEVAN W ,  GIRANDA VINCENT L ,  HEXAMER LAURA ,  LIN NAN-HORNG ,  MIYASHIRO JULIE M ,  PENNING THOMAS D ,  PRZYTULINSKA MAGDALENA ,  SOWIN THOMAS ,  SULLIVAN GERARD ,  TAO ZHI-FU ,  TONG YUNSONG ,  VASUDEVAN ANIL ,  WANG LE ,  WOODS KEITH W ,  XIA ZHIREN ,  ZHANG HENRY Q

IPC: C07C225/20 ,  A61K31/132 ,  A61K31/505 ,  A61P35/00 ,  C07D249/14 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, (see formula I) wherein X1, C1, and D1 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting Plk1, Plk1 causes mitotic arrest, and inhibitors of Plk1 are cytotoxic agents that are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.

公开(公告)号：AT292133T

公开(公告)日：2005-04-15

申请号：AT00941678

申请日：2000-06-23

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  CHEN YIYUAN ,  HOLLADAY MARK W ,  KORT MICHAEL E ,  KYM PHILIP R ,  SULLIVAN JAMES P ,  TANG RUI ,  YI LIN ,  ZHANG HENRY Q

IPC: A61K31/4365 ,  A61K31/44 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/00 ,  A61P13/02 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10 ,  A61P25/00 ,  A61P25/06 ,  A61P25/08 ,  A61P43/00 ,  C07C45/00 ,  C07C45/29 ,  C07C45/41 ,  C07C45/63 ,  C07C45/71 ,  C07C205/44 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14 ,  C07D333/00 ,  C07D335/00

公开(公告)号：NO317099B1

公开(公告)日：2004-08-09

申请号：NO20003104

申请日：2000-06-16

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  DRIZIN IRENE ,  HOLLADAY MARK W ,  SULLIVAN JAMES P ,  ZHANG HENRY Q

IPC: A61K31/4365 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/00 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  C07C45/29 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14 ,  C07D211/84 ,  A61K31/44

Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：DK1040097T3

公开(公告)日：2004-08-02

申请号：DK98963249

申请日：1998-12-16

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  SULLIVAN JAMES P ,  DRIZIN IRENE ,  ZHANG HENRY Q ,  HOLLADAY MARK W

IPC: A61K31/4365 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/00 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  C07C45/29 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14 ,  C07D211/84 ,  A61K31/38 ,  A61K31/44

Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：AT264303T

公开(公告)日：2004-04-15

申请号：AT98963249

申请日：1998-12-16

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  HOLLADAY MARK W ,  SULLIVAN JAMES P ,  DRIZIN IRENE ,  ZHANG HENRY Q

IPC: A61K31/4365 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/00 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  C07C45/29 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14 ,  C07D211/84 ,  A61K31/44 ,  A61K31/38

Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.