公开(公告)号：DE10137627A1

公开(公告)日：2003-02-20

申请号：DE10137627

申请日：2001-08-03

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  KNOLL CHRISTIAN ,  MOHRY ANDRE

IPC: C07D213/67 ,  C07D263/42 ,  C07D213/66

Abstract: Continuous production of 5-alkoxy oxazoles (I) comprises heating an alkyl alpha -isocyanoalkanoate ester (II) at a temperature above 80 deg C in the presence of an auxiliary agent and withdrawing the product from the reactor. Continuous production of 5-alkoxy oxazoles of formula (I) comprises heating an alkyl alpha -isocyanoalkanoate ester of formula (II) at a temperature above 80 deg C in the presence of an auxiliary agent and withdrawing the product from the reactor. R1 = optionally substituted 1-6C alkyl; R2 = H or optionally substituted 1-6C alkyl. An Independent claim is also included for a process for producing pyridoxine derivatives of formula (IX), comprising: (1) converting an amino acid of formula (III) to an ester of formula (IV); (2) converting (IV) to a formamido ester of formula (IV); (3) converting (IV) to (II); (4) converting (II) to (I) as above; (5) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (6) converting (VII) to (IX) by acid treatment and deprotection. R3, R4 = protecting groups or together form a protecting group.

公开(公告)号：AT230388T

公开(公告)日：2003-01-15

申请号：AT99941607

申请日：1999-08-13

Applicant: BASF AG

Inventor： KINDLER ALOIS ,  BRUNNER MELANIE ,  TRAGUT CHRISTIAN ,  HENKELMANN JOCHEM

IPC: C07B61/00 ,  C07C29/42 ,  C07C33/044

Abstract: The invention relates to a method for producing alkyne diols by reacting ketones with acetylenic hydrocarbons in an organic solvent in the presence of a base which contains potassium alcoholates of primary and/or secondary alcohols. The alkyne diols are produced while forming adducts which precipitate out of the reaction mixture and which are comprised of alkyne monoalcohols and/or alkyne diols and a base. The stoichiometries of the reaction partners are selected such that gelatinous adducts are formed which comprise a spherical surface, whereby the reaction mixture remains agitable during the entire reaction.

公开(公告)号：DE19907532A1

公开(公告)日：2000-08-31

申请号：DE19907532

申请日：1999-02-22

Applicant: BASF AG

Inventor： BRUNNER MELANIE ,  HENKELMANN JOCHEM ,  KAIBEL GERD ,  KINDLER ALOIS ,  KNOLL CHRISTIAN ,  RUST HARALD ,  TRAGUT CHRISTIAN

IPC: C07C29/17 ,  C07C29/42 ,  C07C29/74 ,  C07C31/18 ,  C07C33/044

Abstract: The invention relates to a method for preparing at least one unsaturated alcohol (B). The method comprises the following steps (I) to (III): (I) reaction of at least one alkali or alkaline earth hydroxide with at least one alcohol (A) in at least one organic solvent (L) so that a mixture (G-I) is obtained which contains at least the alcohol (A), the solvent (L) and an alcoholate (AL); (II) reaction of at least one carbonyl compound of the general structure R-CO-R' with at least one alkine of the general structure R"-CC-H and the mixture (G-I) obtained in step (I) above, so that a mixture (G-II) is obtained which contains at least the alcohol (A), the solvent (L) and an unsaturated alcohol (B); and (III) distillation of the mixture (G-II) obtained in step (II) above so that the at least one alcohol (B) and a mixture (G-III) containing the solvent (L) and the alcohol (A), are obtained. Said method is characterized in that the solvent (L) and the alcohol (A) obtained in step (III) are fed back to step (I) as a mixture.

公开(公告)号：DE19837211A1

公开(公告)日：2000-02-24

申请号：DE19837211

申请日：1998-08-17

Applicant: BASF AG

Inventor： KINDLER ALOIS ,  BRUNNER MELANIE ,  TRAGUT CHRISTIAN ,  HENKELMANN JOCHEM

IPC: C07B61/00 ,  C07C29/42 ,  C07C33/044

Abstract: In the production of alkyne-diols by reaction of ketones with acetylenes in presence of potassium prim. and/or sec. alcoholate, the stoichiometric ratio of the reactants is adjusted so that gel-like alkynol/base adducts with a spherical surface are obtained and the reaction mixture remains able to be stirred throughout. A process for the production of alkyne-diols by reaction of ketones with acetylenic hydrocarbons in organic solvent in presence of a base containing potassium prim. and/or sec. alcoholates, resulting in the formation of adducts of alkynemono- and/or alkynedi-ols and base which are precipitated from the reaction mixture. In this process, the stoichiometric ratio of the reactants is such that gel-like adducts with a spherical surface are obtained and the reaction mixture remains able to be stirred throughout.

公开(公告)号：AT372315T

公开(公告)日：2007-09-15

申请号：AT03778290

申请日：2003-10-28

Applicant: BASF AG

Inventor： DOBLER WALTER ,  BAHR NICOLAUS ,  BREUER KLAUS ,  KINDLER ALOIS

IPC: C07C45/54 ,  C07C45/74 ,  C07C49/203 ,  C07C403/16

Abstract: The invention relates to a continuous process for producing pseudoionones of general formulas (I) and (I') as well as isomers thereof, whereby: R 1 represents CH 3 or (a); R 2 and R 3 represent hydrogen, CH 3 or C 2 H 5 , and; R 4 and R 5 represent hydrogen or CH 3 . These pseudoionones are produced by reacting an aldehyde of formula (II) with an excess of a ketone of general formula (III), whereby R 1 , R 2 and R 3 have the aforementioned meanings, in the presence of water and alkali hydroxide at an increased temperature and in a homogeneous solution. The inventive process is characterized in that: a) the intermixing of the homogeneous solution consisting of aldehyde, ketone and aqueous alkali lye occurs at a temperature ranging from 10 to 120° C.; b) the undissolved water and alkali hydroxide contained in the reaction mixture are subsequently separated out; c) while avoiding back mixing, the homogeneous reaction mixture is then guided through a reactor, which permits a residence time ranging from 2 to 300 minutes, at a temperature that is 10 to 120° C. higher than the boiling point of the lowest-boiling component and under a vapor pressure p ranging from 10 6 to 10 7 Pa; d) the reaction mixture is cooled by expansion; e) ketone is removed from the reaction mixture using vapor flowing in the opposite direction and; f) the raw product is dried and rid from excessive aldehyde and secondary components via a rectification column.

公开(公告)号：ES2279577T3

公开(公告)日：2007-08-16

申请号：ES98932150

申请日：1998-06-10

Applicant: BASF AG

Inventor： STAMM ARMIN ,  JULIUS MANFRED ,  KINDLER ALOIS ,  HENNINGSEN MICHAEL ,  BOTZEM JORG

IPC: C07D233/60 ,  C07D233/56 ,  C07D233/80

Abstract: La invención se refiere a carbonildiimidazoles que tienen la fórmula general (Ia), (Ib), (Ic) o sus mezclas. En estas fórmulas R{sup,1} representa un radical alquilo C{sub,1}-C{sub,4} y R{sup,2} es un hidrógeno o un radical metilo. La invención también se refiere a los ésteres tercbtilo derivados de estos carbonildiimidazoles.

公开(公告)号：CA2548262A1

公开(公告)日：2005-06-23

申请号：CA2548262

申请日：2004-12-10

Applicant: BASF AG

Inventor： DOBLER WALTER ,  MILLER CHRISTIAN ,  KINDLER ALOIS ,  BAHR NICOLAUS ,  SALDEN AXEL

IPC: C07C49/04 ,  C07C45/62 ,  C07C45/74 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D231/18 ,  C07D231/38 ,  C07D231/56 ,  C07D233/54 ,  C07D235/06 ,  C07D249/12 ,  C07D257/04 ,  C07D311/72 ,  C07D401/12 ,  C07D403/12 ,  C07D409/04 ,  C07D473/34

Abstract: The invention relates to a method for the production of tetrahydrogeranylacetone (tetrahydropseudoionone) by means of aldolcondensation of citral with acetone and subsequent hydrogenation. The invention also relates to the utilization of the tetrahydrogeranylacetone th us obtained for the production of phytol, isophytol, tocopherol and/or tocopher ol derivatives. The invention further relates to methods for the production of tocopherols and/or tocopherol derivatives.

公开(公告)号：DE10123066A1

公开(公告)日：2002-11-14

申请号：DE10123066

申请日：2001-05-11

Applicant: BASF AG

Inventor： ANSMANN ANDREAS ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  ETZRODT HEINZ ,  OOST CARSTEN ,  STUTZ SUSANNE ,  TRAGUT CHRISTIAN ,  BOCKSTIEGEL BERNHARD ,  REIMER KLAUS ,  STROEZEL MANFRED ,  DOBLER WALTER

IPC: B01J23/44 ,  B01J23/50 ,  B01J35/04 ,  B01J35/06 ,  B01J37/02 ,  C07B61/00 ,  C07C29/17 ,  C07C29/32 ,  C07C29/42 ,  C07C33/02 ,  C07C33/048 ,  C07C45/48 ,  C07C45/62 ,  C07C45/67 ,  C07C49/203

公开(公告)号：HU0003361A2

公开(公告)日：2001-02-28

申请号：HU0003361

申请日：1998-06-10

Applicant: BASF AG

Inventor： BOTZEM JOERG ,  HENNINGSEN MICHAEL ,  JULIUS MANFRED ,  KINDLER ALOIS ,  STAMM ARMIN

IPC: C07D233/56 ,  C07D233/60 ,  C07D233/80

Abstract: Carbonyldiimidazoles of the formulae Ia, Ib, Ic or mixtures thereofwhere R1 is C1-4-alkyl and R2 is hydrogen or methyl, and tert-butyl esters derived therefrom are described.

公开(公告)号：DE10209447A1

公开(公告)日：2003-09-18

申请号：DE10209447

申请日：2002-03-05

Applicant: BASF AG

Inventor： KINDLER ALOIS ,  RUST HARALD ,  BURKART KIRSTEN ,  KNOLL CHRISTIAN ,  HENKELMANN JOCHEM

IPC: C07D213/66 ,  B01D3/14 ,  B01J14/00 ,  C07D213/67 ,  C07D263/42 ,  C07B37/12

Abstract: Continuous production of 5-alkoxy oxazoles (I) comprises heating an alkyl alpha-isocyanoalkanoate ester (II) at a temperature above 80 degreesC in the presence of an auxiliary agent and withdrawing the product from the reactor. Continuous production of 5-alkoxy oxazoles of formula (I) comprises heating an alkyl alpha-isocyanoalkanoate ester of formula (II) at a temperature above 80 degreesC in the presence of an auxiliary agent and withdrawing the product from the reactor. R1 = optionally substituted 1-6C alkyl; R2 = H or optionally substituted 1-6C alkyl. An Independent claim is also included for a process for producing pyridoxine derivatives of formula (IX), comprising: (1) converting an amino acid of formula (III) to an ester of formula (IV); (2) converting (IV) to a formamido ester of formula (IV); (3) converting (IV) to (II); (4) converting (II) to (I) as above; (5) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (6) converting (VII) to (IX) by acid treatment and deprotection. R3, R4 = protecting groups or together form a protecting group.