公开(公告)号：DE4341400A1

公开(公告)日：1995-06-08

申请号：DE4341400

申请日：1993-12-04

Applicant: BASF AG

Inventor： STEINER GERD DR ,  MUNSCHAUER RAINER DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  HOEGER THOMAS DR

IPC: C07D209/72 ,  A61K31/40 ,  C07D417/06 ,  C07D471/18 ,  C07D487/18 ,  C07D491/18

Abstract: 4,7-Bridged tetra- or hexa hydro-isoindoline derivs. of formula (I) and their acid-addn. salts are new. B = CH2, C2H4, NH, NMe or NCOMe; R1 = H or phenyl, opt. mono- or disubstd. by halo, 1-4C alkyl, CF3, OH, 1-4C alkoxy, NH2, NHMe, NMe2, CN or NO2; n = 0-4; A = H, CR2R4, N(R5)COR4, N(R5)SO2R4, OSO2R4, CH = CHR4, or CH=C(R4)2; R2 = H, OH, or phenyl opt. substd. by F, Cl or Br; R3 = H; or R2 + R3 = O; R4 = phenyl, or thienyl opt. mono- or disubstd. by F, Cl, Br, OH, NO2, NH2, 1-4C alkanoylamino, 1-4C alkylamino, 1-4C alkyl or OMe; R5 = H or Me.

公开(公告)号：DE4338397A1

公开(公告)日：1995-05-11

申请号：DE4338397

申请日：1993-11-10

Applicant: BASF AG

Inventor： STEINER GERD DR ,  MUNSCHAUER RAINER DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  HOEGER THOMAS DR

IPC: C07D403/06 ,  C07D491/18 ,  A61K31/505 ,  A61K31/53 ,  A61K31/54 ,  C07D471/04 ,  C07D513/04 ,  C07D519/00

Abstract: Compounds of the formula I wherein B, R , R , n, A, X, Y, Z and the 5,6 bond have the meaning indicated in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.

公开(公告)号：DE4119756A1

公开(公告)日：1992-12-17

申请号：DE4119756

申请日：1991-06-15

Applicant: BASF AG

Inventor： RENDENBACH-MUELLER BEATRICE DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME

IPC: A61K31/435 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61P9/12 ,  A61P25/16 ,  A61P25/18 ,  C07D277/20 ,  C07D277/40 ,  C07D277/54 ,  C07D417/12 ,  C07D417/14

Abstract: Described are aminoalkyl-substituted 5-mercaptothiazoles of formula (I), in which R , n and A are as defined in the description, as well as their preparation. The compounds are suitable for use in the treatment of illnesses.

公开(公告)号：DE3834861A1

公开(公告)日：1990-04-19

申请号：DE3834861

申请日：1988-10-13

Applicant: BASF AG

Inventor： RENDENBACH BEATRICE DR ,  WEIFENBACH HARALD DR ,  TESCHENDORF HANS-JUERGEN DR ME

IPC: A61K31/00 ,  A61K31/37 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/16 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  C07D311/16

Abstract: Arylalkoxycoumarins of the general formula I I where R1 and R2 independently of one another are each hydrogen, lower alkyl, phenyl or halogen, or the two radicals together form an alkylene bridge of 3 to 5 carbon atoms, R3 is lower alkyl or halogen, n is an integer of from 0 to 3, m is an integer of from 0 to 4, R4 is hydrogen or lower alkyl and Ar is a phenyl ring which is monosubstituted to trisubstituted by halogen, C1-C6-alkyl or C1-C6-alkoxy or monosubstituted by nitro, cyano or trifluoromethyl or is a naphthyl ring, with the proviso that m is not 0 when Ar is unsubstituted phenyl, processes for their preparation, and drugs prepared therefrom.

公开(公告)号：DE3436550A1

公开(公告)日：1985-04-25

申请号：DE3436550

申请日：1984-10-05

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  KROPP RUDOLF ,  REICHENEDER FRANZ DR ,  GRIES JOSEF DR MED ,  HOFMANN HANS PETER DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  TRAUT MARTIN DR

IPC: C07D237/20 ,  A61K31/50

Abstract: 1-Phenyl-4(1H)-pyridazinone imines substituted on the imine nitrogen atom, of the formula (I) and their acid addition salts with a physiologically tolerated acid, process for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs, especially as antidepressants, antiparkinson drugs and antihypotensives.

公开(公告)号：DE3243518A1

公开(公告)日：1984-05-30

申请号：DE3243518

申请日：1982-11-25

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  MICHEL ALFRED ,  TESCHENDORF HANS-JUERGEN DR ME ,  KREISKOTT HORST PROF DR ,  HOFMANN HANS PETER DR ,  TRAUT MARTIN DR

IPC: C07C225/18 ,  A61K31/135 ,  A61K31/205 ,  A61K31/395 ,  A61P25/24 ,  A61P25/26 ,  C07D207/08 ,  C07D211/32 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/145 ,  C07C97/10

Abstract: 1-Oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahydronaphthalenes of the formula I I where R1 and R2 are identical or different and are each hydrogen, halogen, trifluoromethyl, C1-C4-alkyl or C1-C4-alkoxy, R3 is C1-C6-alkyl and R4 is hydrogen, C1-C6-alkyl or benzyl, or R3 and R4 together may furthermore be a C2-C5-alkylene chain, and their salts with physiologically tolerated acids, and their preparation, are described. The novel compounds are useful active compounds for treating disorders.

公开(公告)号：DE3242477A1

公开(公告)日：1984-05-24

申请号：DE3242477

申请日：1982-11-18

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  STEINER GERD DR ,  HOFMANN HANS PETER DR ,  MUELLER CLAUS D DR MED ,  TESCHENDORF HANS-JUERGEN DR ME

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/425 ,  A61K31/428 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D209/46 ,  C07D209/48 ,  C07D275/04 ,  C07D275/06 ,  C07D495/04 ,  C07D513/04

公开(公告)号：DE3108427A1

公开(公告)日：1982-09-23

申请号：DE3108427

申请日：1981-03-06

Applicant: BASF AG

Inventor： STEINER GERD DIPL CHEM DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST DR ,  TESCHENDORF HANS-JUERGEN DR ME

IPC: C07D263/20 ,  C07D495/14 ,  C07D413/14 ,  A61K31/42 ,  A61K31/495 ,  A61K31/55 ,  C07D409/14 ,  C07D413/06 ,  C07D495/06

Abstract: The invention relates to tricyclic 3-[2-(1-piperazinyl)ethyl]-2-oxazolidinone derivatives, process for their preparation and therapeutic compositions which contain them and can be used as sedatives, hypnotics, tranquillisers or neuroleptics.

公开(公告)号：DE4427647A1

公开(公告)日：1996-02-08

申请号：DE4427647

申请日：1994-08-04

Applicant: BASF AG

Inventor： STEINER GERD DR ,  MUNSCHAUER RAINER DR ,  HOEGER THOMAS DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME

IPC: C07D409/12 ,  A61K31/40 ,  A61K31/403 ,  A61P25/18 ,  A61P43/00 ,  C07D209/44 ,  C07D209/52 ,  C07D209/90 ,  C07D209/92 ,  C07D403/06 ,  C07D209/80 ,  C07D209/34 ,  A61K31/645

Abstract: New compounds having the formula (I), in which A, R and n have the meanings given in the description, are useful for fighting diseases.

公开(公告)号：DE4425146A1

公开(公告)日：1996-01-18

申请号：DE4425146

申请日：1994-07-15

Applicant: BASF AG

Inventor： HELLENDAHL BEATE DR ,  LANSKY ANNEGRET DR ,  RENDENBACH-MUELLER BEATRICE DR ,  BACH ALFRED DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  WICKE CARSTEN DR

IPC: C07D233/84 ,  A61K31/33 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D213/56 ,  C07D213/64 ,  C07D213/65 ,  C07D213/70 ,  C07D213/73 ,  C07D213/79 ,  C07D213/81 ,  C07D233/90 ,  C07D307/79 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38 ,  C07D471/18 ,  A61K31/52

Abstract: The present invention relates to the use of heterocyclic compounds of formula (I) Het - A - B - Ar in which Het A, B and Ar have the meanings given in the description. The compounds of the invention have a high affinity for the dopamine-D3-receptor and are therefore usable for the treatment of diseases responding to dopamine-D3-ligands.