中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

65 records (took 0.058 seconds)

    HAIR-GROWING INHIBITOR
    21.
    发明专利
    HAIR-GROWING INHIBITOR 失效

    公开(公告)号：JPH11106321A

    公开(公告)日：1999-04-20

    申请号：JP27087497

    申请日：1997-10-03

    Applicant: KAO CORP

    Inventor： TSUJI NAOKO ,  MORIWAKI SHIGERU ,  TAKEMA YOSHINORI ,  KANAZAWA SATOSHI ,  NISHIZAWA YOSHINORI ,  IMOKAWA GENJI

    IPC: A61K8/00 ,  A61K8/97 ,  A61Q7/02 ,  A61Q9/04 ,  A61K7/155

    Abstract: PROBLEM TO BE SOLVED: To obtain a hair-growing inhibitor which shows excellent hair-growing inhibitory activity and is high in the safety by formulating a specific plant extract thereto. SOLUTION: This inhibitor contains an extract from a plant selected from ginger, hydrolyzed almond, burnet, clove, rose fruit, hawthorn, white birch and gambir in an amount of 0.0001-50 wt.%, preferably 0.001-10 wt.%, as the dry solid. The above-stated plant extract other than the hydrolyzed almond is an extract obtained by extracting crushed pieces of the above-stated plants with various solvents or by the use of extraction tools, its diluent, its concentrate or its dried powder, and the hydrolyzed almond is obtained by immersing silk fibers into a mixture of an acid or an alkali and water and/or ethanol usually at 3-100 deg.C and then removing insoluble matters.

    BENZOIC ACID AMIDE DERIVATIVE
    22.
    发明专利
    BENZOIC ACID AMIDE DERIVATIVE 失效

    公开(公告)号：JPH08157436A

    公开(公告)日：1996-06-18

    申请号：JP30486994

    申请日：1994-12-08

    Applicant: KAO CORP

    Inventor： FUJIMORI TAKETOSHI ,  AMANO SHINYA ,  SUZUKI YASUTO ,  OHASHI YUKIHIRO ,  FUJIMURA TSUTOMU ,  TAKEMA YOSHINORI

    IPC: A61K31/165 ,  A61P17/00 ,  C07C235/46 ,  C07C235/48

    Abstract: PURPOSE: To obtain the subject novel compound having a synthesis-accelerating activity to human cutis and an improving activity to wrinkle caused by aging or ultraviolet light, excellent percutaneous absorbency and chemical stability, etc. and useful as a cutaneous external application. CONSTITUTION: This compound is expressed by the formula I [R is an 8-24C hydroxyalkyl or 3,7,11-trimethyl-2,6,10-dodecatrienyl; R and R are each H or an (OH-substituted) 1-3C alkyl], e.g. 4-[(2E,6E)-3,7,11-trimethyl-2,6,10- dodecatrienyloxy] benzamide. The compound of the formula I is obtained by reacting 1 mole a compound of the formula II with 0.5-3 moles a compound of the formula R -Y (Y is a halogen or an eliminating group such as p- toluenesulfonyl) in the presence of a base such as sodium hydride in an inert solvent such as DMF at 0-150 deg.C, especially 20-100 deg.C.

    THREE-DIMENSIONAL SHAPE MEASURING APPARATUS FOR SKIN SURFACE
    23.
    发明专利
    THREE-DIMENSIONAL SHAPE MEASURING APPARATUS FOR SKIN SURFACE 失效

    公开(公告)号：JPH08145639A

    公开(公告)日：1996-06-07

    申请号：JP30952794

    申请日：1994-11-18

    Applicant: KAO CORP

    Inventor： KAZAMA HARUHITO ,  OSANAI TSUKASA ,  TAKEMA YOSHINORI ,  AKASAKI SHUICHI ,  KAWAI MICHIO

    IPC: G01B11/24 ,  A61B5/107 ,  G01C3/06 ,  G06T1/00 ,  G06T7/00

    Abstract: PURPOSE: To measure the three-dimensional shape of wrinkles on the surface of skin accurately and conveniently. CONSTITUTION: The apparatus for measuring the three-dimensional shape on the surface of skin comprises a knife-edge illumination means 1 for projecting a parallel light L to a skin surface S to form a dark and bright pattern thereon, means 2 for receiving the light projected from the knife-edge illumination means 1 and reflected on the skin surface S, a signal processing means for calculating the shape of the skin surface S based on the pattern of light received by the light receiving means 2, and means for shifting the knife-edge illumination means 1 and the light receiving means 2 integrally.

    WRINKLE IMPROVER AND KERATINIZATION IMPROVER
    24.
    发明专利
    WRINKLE IMPROVER AND KERATINIZATION IMPROVER 失效

    公开(公告)号：JPH06271448A

    公开(公告)日：1994-09-27

    申请号：JP6060293

    申请日：1993-03-19

    Applicant: KAO CORP

    Inventor： OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  KUSUOKU HIROSHI ,  KAWAMATA AKIRA ,  TAKEMA YOSHINORI ,  OSU HIROYUKI ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  IMOKAWA GENJI

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61P17/16 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE:To obtain a wrinkle improver and keratinization improver excellent in action capable of suppressing occurrence of wrinkle and removing wrinkle and suppressing parakeratosis of skin, hyperplasia of epidermis and abnormality of lipometabolism and excellent in recovery of normal function and retention of homeostasis. CONSTITUTION:The wrinkle improver and keratinization improver consists of an amine derivative of formula I (R is 8-40C straight-chain or branched chain hydrocarbon group which may have OH; R to R are H or 1-7C hydrocarbon group which may have OH; R is 2-6C hydrocarbon group which may have OH; X is OR , CO2R or CONR R (R to R are H or 1-20C hydrocarbon which contains O) or its acid addition salt or quaternary compound, e.g. 1-(2 hydroxyethylamino)-2,16-hexadecanediol. This compound has action capable of suppressing DNA synthesis of an epidermic cell, promoting differential induction and suppressing hyperplasia of epidermis. The compound of formula I is obtained by subjecting an alcohol of formula 2 to halogenation or sulfonic acid esterification and adding an amine of formula 4 to the resultant compound of formula 3.

    EXTERNAL PREPARATION COMPOSITION
    25.
    发明专利
    EXTERNAL PREPARATION COMPOSITION 失效

    公开(公告)号：JPH01213213A

    公开(公告)日：1989-08-28

    申请号：JP3922688

    申请日：1988-02-22

    Applicant: KAO CORP

    Inventor： OKAMURA NORIKO ,  SAITO KAZUMI ,  TAKEMA YOSHINORI ,  SUZUKI TOSHIYUKI

    IPC: A61K36/18 ,  A61K8/00 ,  A61K8/72 ,  A61K8/73 ,  A61K8/96 ,  A61K8/97 ,  A61K31/715 ,  A61K36/00 ,  A61P17/00 ,  A61Q5/00 ,  A61Q19/00 ,  C08B37/00

    Abstract: PURPOSE:To obtain external preparation composition having excellent effects for skin such as keeping wet, protect, softening and smoothing, containing acidic heteropolysaccharides obtained from a plant belonging to Polianthes L. CONSTITUTION:An external preparation composition is mixed with 0.00001-10wt.%, preferably 0.001-5wt.% acidic heteropolysaccharides containing arabinose, mannose, galactose, xylose and glucuronic acid obtained from a plant belonging to Polianthes L., especially Polianthes tuberosa L. The acidic heteropolysaccharides is obtained by following process; A part of a flower of Polianthes tuberosa L., etc., is used as an explant piece. Callus is derived using a medium comprising a fundamental medium, phytohormone and sugar as a carbon source. Then, the callus is transferred to a liquid medium and subjected to shake culture. Cells are removed from said cultured substance by centrifugation or filtration and condensed. Ethanol is added to the condensed liquid and a precipitate occurs. The precipitate is freeze-dried to afford the aimed composition.

    EXTERNAL APPLICATION FOR SKIN
    28.
    发明专利
    EXTERNAL APPLICATION FOR SKIN 失效

    公开(公告)号：JPH06321766A

    公开(公告)日：1994-11-22

    申请号：JP2018494

    申请日：1994-02-17

    Applicant: KAO CORP

    Inventor： OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  KAWAMATA AKIRA ,  TAKEMA YOSHINORI ,  OSU HIROYUKI ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  IMOKAWA GENJI ,  KUSUOKU HIROSHI ,  FUJIMURA TSUTOMU

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/41 ,  A61K31/13 ,  A61P17/00 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE:To obtain a medicine for external application for skin expressing antidandruff effect and improving effect after sunburn, excellent in preventing and improving effects on plication, capable of keeping the normal function of skin by containing an amine derivative as an effective component. CONSTITUTION:This medicine contains a compound of the formula (R is 1-3C hydrocarbon or 1-5C hydrocarbon containing a hetero atom; R -R are H, 1-20C hydrocarbon capable of being substituted with OH) or its acid adduct salt as an effective component. The compounding ratio is 0.0001-5wt.% for the external medicine for skin of emulsion type and 0.0001-10wt.% for an oily external medicine for skin using a liquid hydrocarbon such as squalane, etc., as a substrate. 1-(2-Hydroxyethylamino)-3-methoxy-2-propanol is an example of a compound of the formula. The external medicine for skin controls occurrence of plication, expresses marked effect on disappearing plication, further expresses marked controlling action on parakeratosis, acanthosis, abnormal lipids metabolism, etc., and contributes to recover the normal function of skin and maintain its homeostasis.

    WRINKLE IMPROVER
    29.
    发明专利
    WRINKLE IMPROVER 失效

    公开(公告)号：JPH06271446A

    公开(公告)日：1994-09-27

    申请号：JP6059993

    申请日：1993-03-19

    Applicant: KAO CORP

    Inventor： TAKEMA YOSHINORI ,  OGAWA AYUMI ,  FUJIMURA TSUTOMU ,  KUSUOKU HIROSHI ,  OHASHI YUKIHIRO ,  KAWAMATA AKIRA ,  IMOKAWA GENJI

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/40 ,  A61K8/41 ,  A61K8/44 ,  A61K8/55 ,  A61K8/58 ,  A61K8/68 ,  A61P17/16 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE:To obtain a wrinkle improver having excellent action capable of suppressing occurrence of wrinkle and removing wrinkle. CONSTITUTION:The wrinkle improver contains a sphingosine analogue of the formula [R is 1-40C straight-chain, branched chain or cyclic hydrocarbon group which may have OH; X is CH2OH, CO2H, CH2OP(=0) (OH)2; Y is NH2, NHCH3, N(CH3)2 or N (CH3)3, e.g. D-erythrosphingosine as an active ingredient. Although the wrinkle improver can be administered by oral, external or other any method, the improver is preferably applied as a skin external preparation, e.g. ointment and the blend amount of the compound of the formula is preferably 0.0001-5wt.%, especially preferably 0.0001-1wt.% in an emulsion type skin external preparation and preferably 0.001-10wt.%, especially preferably 0.005-2wt.% in an oily skin external preparation.

    SKIN EXTERNAL PREPARATION
    30.
    发明专利
    SKIN EXTERNAL PREPARATION 失效

    公开(公告)号：JPH06271444A

    公开(公告)日：1994-09-27

    申请号：JP5725193

    申请日：1993-03-17

    Applicant: KAO CORP

    Inventor： OHASHI YUKIHIRO ,  KAWAMATA AKIRA ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  TAKEMA YOSHINORI ,  OSU HIROYUKI ,  IMOKAWA GENJI

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K8/63 ,  A61K31/13 ,  A61K31/16 ,  A61K31/215 ,  A61P17/00 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE:To obtain a skin external preparation excellent in action capable of suppressing occurrence of wrinkle and removing wrinkle and suppressing parakeratosis of skin, hyperplasia of epidermis and abnormality of lipometabolism and excellent in the recovery of normal function and retention of homeostasis. CONSTITUTION:The skin external preparation contains an amine derivative of formula I (R is 1-40C straight-chain, branched chain or cyclic hydrocarbon group which may contain a hetero atom; R and R are H or 1-10C hydrocarbon groups whose hydrogen atom may be substituted with OH; R is 2-10C hydrocarbon group which may be substituted with OH; A is CO2, S or formula 4) or its acid addition salt or quaternary compound, e.g. 3-(2-hydroxyethylamino)-1- tetradecylthio-2-propanol. This compound has action capable of suppressing DNA synthesis of an epidermic cell, promoting differential induction and suppressing hyperplasia of epidermis and is preferably blended in this external preparation in an amount of 0.0001-0.1wt.%. The compound of formula I is obtained by adding an amine of formula 3 to an epoxide of formula 2.

Patent Agency Ranking