Patent search ap:("VERTEX PHARMA") AND inv:"MUDUNURI PRAVEEN" Page 3

21.

发明专利
Inhibitors of influenza viruses replication 未知

公开(公告)号：AU2014348840A1

公开(公告)日：2016-05-26

申请号：AU2014348840

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME W , WALDO MICHAEL , O'NEIL SIMON ADAM , VAN ALSTEN JOHN GREGG , MACIKENAS DAINIUS , MUDUNURI PRAVEEN , SHI YI , LEDEBOER MARK WILLEM , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH MARIE , TSAI WANJUNG

IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04

Abstract: Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1)·1/2&EEgr;

22.

发明专利
Pharmaceutical compositions comprising cftr modulators and administrations thereof 未知

公开(公告)号：NZ603042A

公开(公告)日：2015-02-27

申请号：NZ60304211

申请日：2011-04-22

Applicant: VERTEX PHARMA

Inventor： JOHNSTON STEVEN C , KRAWIEC MARIUSZ , ZAMAN NOREEN TASNEEM , KESHAVARZ-SHOKRI ALI , ZLOKARNIK GREGOR , ALARGOVA ROSSITZA GUEORGUIEVA , AREKAR SNEHA G , ZHANG YUEGANG , VAN GOOR FREDRICK F , MEDEK ALES , ALCACIO TIM EDWARD , ZHANG BEILI , MUDUNURI PRAVEEN , KADIYALA IRINA NIKOLAEVNA , LEE ELAINE CHUNGMIN , SULLIVAN MARK JEFFREY

IPC: A61K31/404 , A61K31/36 , A61K31/47 , C07D209/12 , C07D215/233 , C07D215/56 , C07D317/46

Abstract: Disclosed is a pharmaceutical composition comprising: Compound 1 SDD Formulation and VX-661 in Amorphous Form, wherein: Compound 1 SDD Formulation is a spray dried dispersion of ivacaftor (VX-770), which comprises from about 45 wt% to about 85 wt% of substantially amorphous ivacaftor by weight of the dispersion, from about 14.45 wt% to about 55.55 wt% of hydroxypropylmethylcellulose acetate succinate (HPMCAS) by weight of the dispersion, and from about 0.45 wt% to about 0.55 wt% sodium lauryl sulfate (SLS) by weight of the dispersion. Also disclosed is the use of the pharmaceutical composition as defined above in the manufacture of a medicament for treating a CFTR mediated disease in a human, wherein the CFTR mediated disease is selected from cystic fibrosis, COPD, emphysema, dry-eye disease or osteoporosis.

23.

发明专利
SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 未知

公开(公告)号：CA2699292A1

公开(公告)日：2009-03-26

申请号：CA2699292

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN , FENG YUSHI , HARRISON CRISTIAN , LOOKER ADAM , MUDUNURI PRAVEEN , ROEPER STEFANIE , ZHANG YUEGANG

IPC: A61K31/47 , A61P3/00 , A61P3/10 , A61P25/28 , A61P27/02 , A61P35/00 , C07D215/233

Abstract: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.

24.

发明专利
Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 未知

公开(公告)号：AU2008301907A1

公开(公告)日：2009-03-26

申请号：AU2008301907

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： ZHANG YUEGANG , DEMATTEI JOHN , MUDUNURI PRAVEEN , HARRISON CRISTIAN , LOOKER ADAM , ROEPER STEFANIE , FENG YUSHI

IPC: A61K31/47 , A61P3/00 , A61P3/10 , A61P25/28 , A61P27/02 , A61P35/00 , C07D215/233

25.

发明专利
CO-CRYSTALS OF (S)-N-METHYL-8-(1-((2'-METHYL-[4,5'-BIPYRIMIDIN]-6-YL)AMINO)PROPAN-2-YL)QUINOLINE-4-CARBOXAMIDE AND DEUTERATED DERIVATIVES THEREOF AS DNA-PK INHIBITORS 未知

公开(公告)号：CA2927631C

公开(公告)日：2022-05-17

申请号：CA2927631

申请日：2014-10-17

Applicant: VERTEX PHARMA

Inventor： KADIYALA IRINA NIKOLAEVNA , O'NEIL SIMON ADAM , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , STAVROPOULOS KATHY , MUDUNURI PRAVEEN , SONG BIN , VAN ALSTEN JOHN GREGG , NTI-ADDAE KWAME WIREDU , ZHANG YUEGANG

IPC: C07D401/14 , A61K31/506 , A61P35/00

Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

26.

发明专利
Co-cristales de (S)-N-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il)amino)propan-2-il)quinolin-4-carboxamida y derivados deuterados de la misma como inhibidores de DNA-PK 未知

公开(公告)号：ES2802296T3

公开(公告)日：2021-01-18

申请号：ES18188034

申请日：2014-10-17

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA

IPC: C07D401/14 , A61K31/506 , A61P35/00

Abstract: Un co-cristal que comprende un compuesto de fórmula **(Ver fórmula)** y un formador de co-cristal, en la que el formador de co-cristales es ácido adípico, en la que cada uno de R1 y R2 es independientemente hidrógeno o deuterio, para su uso en la potenciación de un régimen terapéutico para el tratamiento del cáncer, en la que el uso comprende administrar a un individuo que lo necesite una cantidad efectiva de dicho co-cristal, y en la que el régimen terapéutico es la radioterapia.