公开(公告)号：CA2329422A1

公开(公告)日：1999-10-28

申请号：CA2329422

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： MADIGAN DAROLD L ,  LIN ZHEN ,  KRUEGER ALLAN C ,  MARING CLARENCE J ,  DEGOEY DAVID A ,  XU YIBO ,  YEUNG MING C ,  FLOSI WILLIAM J ,  ZHAO CHEN ,  KENNEDY APRIL ,  MUCHMORE STEVEN W ,  STEWART KENT D ,  KEMPF DALE J ,  SHAM HING L ,  GRAMPOVNIK DAVID J ,  STOLL VINCENT S ,  KATI WARREN M ,  WANG GARY T ,  GU YU-GUI ,  SUN MINGHUA ,  WANG SHELDON ,  MCDANIEL KEITH F ,  GIRANDA VINCENT L ,  KLEIN LARRY L ,  CHEN YUANWEI ,  CHEN HUI-JU

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40 ,  C07D407/04

Abstract: Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

公开(公告)号：ZA983175B

公开(公告)日：1998-10-21

申请号：ZA983175

申请日：1998-04-15

Applicant: ABBOTT LAB

Inventor： BHAGWAT SHRIPAD S ,  PERNER RICHARD J ,  GU YU-GUI

IPC: A61P25/04 ,  A61K31/519 ,  A61P1/00 ,  A61P3/10 ,  A61P9/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P29/00 ,  A61P31/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  C07D ,  A61K

Abstract: A compound having formula (II) wherein R , R , R , R and R are defined, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, pain, nociperception, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods for preparation thereof.