公开(公告)号：EP2007381A4

公开(公告)日：2010-11-17

申请号：EP07758000

申请日：2007-03-06

Applicant: ABBOTT LAB

Inventor： KEMPF DALE J ,  MARSH KENNAN C

IPC: A61K31/425 ,  A61K31/403 ,  A61K31/497 ,  A61P31/12

CPC classification number: A61K38/212 ,  A61K31/407 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/7056 ,  A61K2300/00

公开(公告)号：EP1993820A4

公开(公告)日：2009-04-15

申请号：EP07757576

申请日：2007-02-27

Applicant: ABBOTT LAB

Inventor： KEMPF DALE J ,  FLENTGE CHARLES A ,  RANDOLPH JOHN T ,  HUANG PEGGY ,  KLEIN LARRY L

IPC: B29D99/00 ,  D01D5/00

CPC classification number: C07D277/30 ,  A61K31/426 ,  A61K31/427 ,  A61K45/06 ,  C07C53/18 ,  C07D213/30 ,  C07D231/12 ,  C07D233/64 ,  C07D263/32 ,  C07D277/24 ,  C07D277/38 ,  C07D277/587 ,  C07D333/16 ,  C07D417/04

Abstract: Novel compounds of formula I, or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.

公开(公告)号：WO2010030359A3

公开(公告)日：2010-05-27

申请号：PCT/US2009005082

申请日：2009-09-10

Applicant: ENANTA PHARJMACEUTICALS INC ,  ABBOTT LAB ,  KU YIYIN ,  MCDANIEL KEITH F ,  CHEN HUI-JU ,  SHANLEY JASON P ,  KEMPF DALE J ,  GRAMPOVNIK DAVID J ,  SUN YING ,  LIU DONG ,  GAI YONGHUA ,  OR YAT SUN ,  WAGAW SABLE H ,  ENGSTROM KEN ,  GRIEME TIM ,  SHEIKH AHMAD ,  MEI JIANZHANG

Inventor： KU YIYIN ,  MCDANIEL KEITH F ,  CHEN HUI-JU ,  SHANLEY JASON P ,  KEMPF DALE J ,  GRAMPOVNIK DAVID J ,  SUN YING ,  LIU DONG ,  GAI YONGHUA ,  OR YAT SUN ,  WAGAW SABLE H ,  ENGSTROM KEN ,  GRIEME TIM ,  SHEIKH AHMAD ,  MEI JIANZHANG

IPC: A61K38/00 ,  A61K38/12

CPC classification number: C07K1/113 ,  C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

Abstract translation: 本发明涉及新的大环化合物及其使用方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。

公开(公告)号：WO2007076034A3

公开(公告)日：2007-10-04

申请号：PCT/US2006049079

申请日：2006-12-20

Applicant: ABBOTT LAB ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  MARING CLARENCE J ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  ROCKWAY TODD W ,  COOPER CURT S ,  ANDERSON DAVID D ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  LIU DACHUN ,  MCDANIEL KEITH F ,  MADIGAN DAROLD L ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE VL ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN ,  GRAMPOVNIK DAVID J

Inventor： BETEBENNER DAVID A ,  DEGOEY DAVID A ,  MARING CLARENCE J ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  ROCKWAY TODD W ,  COOPER CURT S ,  ANDERSON DAVID D ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  LIU DACHUN ,  MCDANIEL KEITH F ,  MADIGAN DAROLD L ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE VL ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN ,  GRAMPOVNIK DAVID J

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：WO0234909A3

公开(公告)日：2003-11-13

申请号：PCT/US0148040

申请日：2001-10-26

Applicant: ABBOTT LAB

Inventor： STEWART KENT D ,  STEFFY KEVIN R ,  KEMPF DALE J ,  HARRIS KEVIN S ,  HUTH JEFFREY R ,  STOLL VINCENT S ,  HARLAN JOHN E ,  NG IOK C ,  BETZ STEPHEN F

IPC: G01N33/566 ,  C07K14/16 ,  C07K16/10 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C40B30/04 ,  G01N33/15 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G01N33/68 ,  C12N15/11

CPC classification number: C40B30/04 ,  C07K14/005 ,  C07K2319/00 ,  C12N2740/16122 ,  G01N33/56988 ,  G01N33/6842 ,  G01N33/6845 ,  G01N2500/04

Abstract: The subject invention encompasses novel proteins related to the human immunodeficiency virus (HIV-1) gp41 protein and to methods of use thereof. For example, the proteins may be utilized in the screening of anti-HIV compounds.

Abstract translation: 本发明涵盖与人免疫缺陷病毒（HIV-1）gp41蛋白相关的新型蛋白质及其使用方法。 例如，蛋白质可用于筛选抗HIV化合物。

公开(公告)号：WO0129020A9

公开(公告)日：2002-10-03

申请号：PCT/US0027090

申请日：2000-10-02

Applicant: ABBOTT LAB

Inventor： STEWART KENT D ,  KEMPF DALE J ,  KLEIN LARRY L ,  MARING CLARENCE J ,  STOLL VINCENT S

IPC: A61K31/35 ,  A61P31/16 ,  C07D309/28

CPC classification number: C07D309/28

Abstract: The present invention provides compounds which are neuraminidase inhibitors characterized by a unique three-dimensional conformation and orientation relative to the Sites of Occupation 1-4 of the enzyme. Also provided are pharmaceutical compositions containing said compounds, as well as methods of using said compounds and compositions.

Abstract translation: 本发明提供了作为神经氨酸酶抑制剂的化合物，其特征在于相对于酶的占位位置1-4的独特的三维构象和取向。 还提供含有所述化合物的药物组合物，以及使用所述化合物和组合物的方法。

公开(公告)号：WO0128979A3

公开(公告)日：2001-12-27

申请号：PCT/US0027938

申请日：2000-10-10

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN ,  GU YU GUI ,  WANG GARY T ,  KRUEGER ALLAN C ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KENNEDY APRIL L ,  LIN ZHEN ,  MADIGAN DONALD L ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  WANG SHELDON ,  YEUNG MING C

IPC: A61K31/195 ,  C07C233/48 ,  C07C237/24 ,  C07C271/22 ,  C07C271/24 ,  C07C279/16 ,  C07D233/54 ,  C07D263/32 ,  C07D307/24 ,  C07D317/30 ,  C07D405/04 ,  A61K31/325 ,  A61K31/34 ,  A61K31/415 ,  A61K31/42 ,  A61P31/00

CPC classification number: C07D233/64 ,  C07B2200/07 ,  C07B2200/09 ,  C07C233/48 ,  C07C237/24 ,  C07C271/22 ,  C07C271/24 ,  C07C279/16 ,  C07C2601/08 ,  C07C2601/10 ,  C07D263/32 ,  C07D307/24 ,  C07D317/30 ,  C07D405/04

Abstract: Disclosed are compounds of formula (I), (II) or (III) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

Abstract translation: 公开了可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶的式（I），（II）或（III）的化合物。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。

公开(公告)号：AU2013205039A1

公开(公告)日：2013-05-16

申请号：AU2013205039

申请日：2013-04-13

Applicant: ABBOTT LAB ,  ENANTA PHARM INC

Inventor： KU YIYIN ,  MCDANIEL KEITH F ,  CHEN HUI-JU ,  SHANLEY JASON P ,  KEMPF DALE J ,  GRAMPOVNIK DAVID J ,  SUN YING ,  LIU DONG ,  YONGHUA GAI ,  OR YAT SUN ,  WAGAW SABLE H ,  ENGSTROM KEN ,  GRIEME TIM ,  SHEIKH AHMAD ,  MEI JIANZHANG

IPC: A61K38/00 ,  A61K38/12

Abstract: MACROCYCLIC HEPATITIS C SERINE PROTEASE Abstract The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutical acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutical carrier or excipient.

公开(公告)号：PT1560827E

公开(公告)日：2011-03-17

申请号：PT03768559

申请日：2003-10-31

Applicant: ABBOTT LAB

Inventor： KEMPF DALE J ,  PRATT JOHN K ,  BETEBENNER DAVID A ,  DONNER PAMELA L ,  GREEN BRIAN E ,  MCDANIEL KEITH F ,  MARING CLARENCE J ,  STOLL VINCENT S ,  ZHANG RONG

IPC: C07D471/04 ,  A61K31/554 ,  A61P31/00 ,  C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00

公开(公告)号：ZA200700101B

公开(公告)日：2009-10-28

申请号：ZA200700101

申请日：2007-01-03

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  GRAMPOVNIK DAVID J ,  KEMPF DALE J ,  FLOSI WILLIAM J ,  KLEIN LARRY L ,  WANG XIU C

IPC: A61K20100101 ,  A61P20100101 ,  C07F20100101

Abstract: A compound of the formula I, II or III is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions of inhibiting HIV protease activity and treating HIV infection are also disclosed.