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公开(公告)号：CA2236773A1
公开(公告)日：1997-05-22
申请号：CA2236773
申请日：1996-11-13
Applicant: ABBOTT LAB
Inventor： SHEPPARD GEORGE S , STEINMAN DOUGLAS H , SUMMERS JAMES B JR , DAVIDSEN STEVEN K , FESIK STEPHEN W , CARRERA GEORGE M JR , HOLMS JAMES H , FLORJANCIC ALAN
IPC: A61K31/16 , A61K31/195 , A61K31/22 , A61K31/275 , A61K31/395 , A61K31/44 , C07C259/06 , C07C317/50 , C07C323/60 , C07C323/62 , C07D213/75 , C07D295/185
Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF.alpha. secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF.alpha. secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF.alpha. secretion.
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公开(公告)号：AU651243B2
公开(公告)日：1994-07-14
申请号：AU2339192
申请日：1992-07-14
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , DAVIDSEN STEVEN K , HOLMS JAMES H , PIREH DAISY , HEYMAN H ROBIN , MARTIN MICHAEL B , STEINMAN DOUGLAS H , SHEPPARD GEORGE S , CARRERA GEORGE M JR
IPC: A61K31/44 , A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00 , A61K31/40
Abstract: PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：PT100698A
公开(公告)日：1993-10-29
申请号：PT10069892
申请日：1992-07-16
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , STEINMAN DOUGLAS H , MARTIN MICHAEL B , CARRERA GEORGE M JR , HOLMS JAMES H , PIREH DAISY , HEYMAN ROBIN H , SHEPPARD GEORGE S , DAVIDSEN STEVE K
IPC: A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61K31/44 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00 , C07D513/00 , C07D498/00 , C07D487/00 , A61K31/40
Abstract: PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：IE920715A1
公开(公告)日：1992-10-07
申请号：IE920715
申请日：1992-03-05
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , STEINMAN DOUGLAS H , GUINN DENISE E , DAVIDSEN STEVEN K , MAY PAUL D
IPC: C07D401/04 , C07D409/04 , C07D417/04 , C07D401/00 , C07D409/00 , C07D417/00
Abstract: Benzoylphenyl derivatives of 2-(3-pyridinyl)-3-alkyl-4-thiazolidinecarboxamide, 2-(3-pyridinyl)-thiazolid-4-ylacetamide, 2-(3-pyridinyl)-4-dithiolanecarboxamide or 2-(3-pyridinyl)dithiolan-4-yl] urea are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：MXPA05013076A
公开(公告)日：2006-03-09
申请号：MXPA05013076
申请日：2004-06-02
Applicant: ABBOTT LAB
Inventor： STEINMAN DOUGLAS H
IPC: A61K31/4035 , A61P35/04 , C07D209/46 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12
Abstract: Los compuestos que tienen la formula (I), son utiles para inhibir proteina tirosinasas. La presente invencion tambien describe metodos para fabricar los compuestos y composiciones que contienen los mismos.
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Patent Agency Ranking
公开(公告)号：CA2553724A1
公开(公告)日：2005-08-18
申请号：CA2553724
申请日：2005-02-03
Applicant: ABBOTT LAB
Inventor： ARNOLD LEE D , TIAN ZHENGPING , FIX-STENZEL SHANNON R , YANG BRYANT , ERICSSON ANNA , STEINMAN DOUGLAS H , HOLMS JAMES H , WITTENBERGER STEVEN J , FRIEDMAN MICHAEL , WISHART NEIL , MICHAELIDES MICHAEL R , QIAN XIAO-DONG
IPC: C07D487/04 , A61K31/519
Abstract: A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.
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37.发明专利
公开(公告)号：BG64307B1
公开(公告)日：2004-09-30
申请号：BG10399599
申请日：1999-12-13
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00
Abstract: The compounds with the formula are inhibitors of matrix metallproteinases. The invention also relates to pharmaceutical compositions and methods for the inhibition of matrix metallproteinases in mammals. 18 claims
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公开(公告)号：ES2196190T3
公开(公告)日：2003-12-16
申请号：ES96940406
申请日：1996-11-13
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , SUMMERS JAMES B JR , DAVIDSEN STEVEN K , SHEPPARD GEORGE S , STEINMAN DOUGLAS H , CARRERA GEORGE M JR
IPC: A61P19/02 , A61K31/185 , A61K31/275 , A61P29/00 , A61P35/04 , A61P43/00 , C07C259/06 , C07C323/60 , A61K31/16
Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.
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公开(公告)号：SI1001930T1
公开(公告)日：2003-08-31
申请号：SI9830356
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07C259/00
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公开(公告)号：PT874808E
公开(公告)日：2003-08-29
申请号：PT96940406
申请日：1996-11-13
Applicant: ABBOTT LAB
Inventor： STEINMAN DOUGLAS H , FESIK STEPHEN W , SHEPPARD GEORGE S , CARRERA GEORGE M JR , SUMMERS JAMES B JR , DAVIDSEN STEVEN K , HOLMS JAMES H , FLORJANCIC ALAN
IPC: A61P19/02 , A61K31/185 , A61K31/275 , A61P29/00 , A61P35/04 , A61P43/00 , C07C259/06 , C07C323/60 , A61K31/16
Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.
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