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公开(公告)号：HK1161259A1
公开(公告)日：2012-08-24
申请号：HK12102075
申请日：2012-02-29
Applicant: VERTEX PHARMA
Inventor： BINCH HAYLEY , FANNING LEV T D , HURLEY DENNIS , SHETH URVI , SILINA ALINA , YANG XIAOQING , BOTFIELD MARTYN , GROOTENHUIS PETER D J , GOOR FREDRICK VAN , NUMA MEHDI MICHEL DJAMEL
IPC: C07D20060101 , A61K20060101 , A61P20060101
Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
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公开(公告)号：ZA201102900B
公开(公告)日：2012-07-25
申请号：ZA201102900
申请日：2011-04-18
Applicant: VERTEX PHARMA
Inventor： BINCH HAYLEY , FANNING LEV T D , HURLEY DENNIS J , SHETH URVI , SILINA ALINA , YANG XIAOQING , BOTFIELD MARTYN C , GROOTENHUIS PETER D J , VAN GOOR FREDERICK , NUMA MEHDI MICHEL DJAMEL
IPC: A61K20060101 , C07D20060101 , A61P20060101 , C12Q20060101
Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
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公开(公告)号：AU2010310612A1
公开(公告)日：2012-06-14
申请号：AU2010310612
申请日：2010-10-21
Applicant: VERTEX PHARMA
Inventor： AMBHAIKAR NARENDRA BHALCHANDRA , HUGHES ROBERT , HURLEY DENNIS JAMES , LEE ELAINE CHUNGMIN , LITTLER BENJAMIN , NUMA MEHDI , ROEPER STEFANIE , SHETH URVI
IPC: C07D215/56 , C07D487/08
Abstract: The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2. 1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A- HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.
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公开(公告)号：CA2783314A1
公开(公告)日：2011-06-16
申请号：CA2783314
申请日：2010-12-10
Applicant: VERTEX PHARMA
Inventor： SHETH URVI , FANNING TEV T D , NUMA MEHDI , BINCH HAYLEY , HURLEY DENNIS JAMES , ZHOU JINGLAN , HADIDA RUAH SARA S , HAZLEWOOD ANNA R , SILINA ALINA , VAIRAGOUNDAR RAJENDRAN , VAN GOOR FREDRICK F , GROOTENHUIS PETER DIEDERIK JAN , BOTFIELD MARTYN C
IPC: C07D215/56 , A61K31/4709 , A61P11/00 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/08
Abstract: The present invention relates to 4-oxo-1H-quinoline-3-carboxamides as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：ZA200804043B
公开(公告)日：2010-01-27
申请号：ZA200804043
申请日：2006-11-13
Applicant: VERTEX PHARMA
Inventor： WILSON DEAN , FANNING LEV T D , KRENITSKY PAUL , TERMIN ANDREAS , JOSHI PRAMOD , SHETH URVI
IPC: A61K20100101 , A61P20100101 , C07D20100101
Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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Patent Agency Ranking
公开(公告)号：NO20082746L
公开(公告)日：2008-08-08
申请号：NO20082746
申请日：2008-06-13
Applicant: VERTEX PHARMA
Inventor： KRENITSKY PAUL , TERMIN ANDREAS , WILSON DEAN , FANNING LEV T D , JOSHI PRAMOD , SHETH URVI
IPC: C07D403/04 , A61K31/505 , A61P29/00
Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：NO20082746A
公开(公告)日：2008-08-08
申请号：NO20082746
申请日：2008-06-13
Applicant: VERTEX PHARMA
Inventor： KRENITSKY PAUL , TERMIN ANDREAS , WILSON DEAN , FANNING LEV T D , JOSHI PRAMOD , SHETH URVI
IPC: C07D403/04 , A61K31/505 , A61P29/00
CPC classification number: C07D403/04
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公开(公告)号：HK1104544A1
公开(公告)日：2008-01-18
申请号：HK07109785
申请日：2007-09-07
Applicant: VERTEX PHARMA
Inventor： WILSON DEAN M , TERMIN ANDREAS P , GONZALEZ JESUS E III , FANNING LEV T D , NEUBERT TIMOTHY D , KRENITSKY PAUL , JOSHI PRAMOD , HURLEY DENNIS J , SHETH URVI , BOGER JOSHUA S
IPC: A61K20100101 , A61P20100101 , C07D20100101
Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：BRPI0919930A2
公开(公告)日：2016-02-16
申请号：BRPI0919930
申请日：2009-10-23
Applicant: VERTEX PHARMA
Inventor： HURLEY DENNIS , GOOR FREDERICK VAN , BINCH HAYLEY , FANNING LEV T D , BOTFIELD MARTYN , NUMA MEHDI MICHEL DJAMEL , GROOTENHUIS PETER D J , SHETH URVI , YANG XIAOQING
IPC: C07D451/02 , A61K31/439 , A61P11/00
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公开(公告)号：ZA201103411B
公开(公告)日：2012-09-26
申请号：ZA201103411
申请日：2011-05-10
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , O'DONNELL MICHAEL , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , PINDER JOANNE , VIRANI ANISA , YOUNG STEPHEN , BINCH HAYLEY , CLEVELAND THOMAS , FANNING LEV T D , HURLEY DENNIS J , JOSHI PRAMOD , SHETH URVI , SILINA ALINA , REAPER PHILIP MICHAEL
IPC: C07D20060101 , A61K20060101 , A61P20060101
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