公开(公告)号：CA1057754A

公开(公告)日：1979-07-03

申请号：CA258274

申请日：1976-08-02

Applicant: ABBOTT LAB

Inventor： WINN MARTIN ,  KYNCL JAROSLAV ,  DUNNIGAN DANIEL A ,  JONES PETER H

IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D307/68

Abstract: Described are antihypertensive agents selected from the class consisting of 24(tetrahydro-2-furoyl)-piperazino!-4-amino-6,7-dimethoxyquinazoline and 2-C4(tetra-hydropyran-2-carbonyl)-piperazinyl!-4-amino-6,7-dimethoxy-q uinazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

公开(公告)号：NO139961B

公开(公告)日：1979-03-05

申请号：NO741141

申请日：1974-03-29

Applicant: ABBOTT LAB

Inventor： WINN MARTIN

IPC: A61K31/435 ,  A61P25/04 ,  A61P25/20 ,  C07C37/055 ,  C07C43/205 ,  C07D491/04 ,  C07D491/052

公开(公告)号：DE2646186A1

公开(公告)日：1977-04-28

申请号：DE2646186

申请日：1976-10-13

Applicant: ABBOTT LAB

Inventor： WINN MARTIN ,  KYNCL JAROSLAV ,  DUNNIGAN DANIEL AMBROSE ,  JONES PETER HADLEY

IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14

Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

公开(公告)号：AU6664974A

公开(公告)日：1975-09-18

申请号：AU6664974

申请日：1974-03-14

Applicant: ABBOTT LAB

Inventor： WINN MARTIN

IPC: C07C37/055 ,  C07D295/14 ,  C07D295/15 ,  C07D311/80 ,  C07D311/94 ,  C07D405/12 ,  C07D99/02 ,  A61K27/00

Abstract: Heterocyclic esters of benzopyrans represented by the formula wherein n is 1 or 2; each R and R1 are the same or different members of the group consisting of hydrogen or loweralkyl; R2 is loweralkyl; R3 is WITH Y' being a straight or branched chain alkylene group having from one to eight carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, X is CH2, O, S or NR7 with R7 being hydrogen or loweralkyl, with the limitation that when X is O, S, or NR7, a and b each must be 2; R8 is hydrogen or loweralkyl; Y is a straight or branched chain alkylene group having from one to ten carbon atoms; and each R4 and R5 and R6 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and the pharmaceutically acceptable salts thereof.

公开(公告)号：CA2594098C

公开(公告)日：2014-04-01

申请号：CA2594098

申请日：2006-01-05

Applicant: ABBOTT LAB

Inventor： PATEL JYOTI R ,  SHUAI QI ,  LINK JAMES T ,  ROHDE JEFFREY J ,  DINGES JURGEN ,  SORENSEN BRYAN K ,  WINN MARTIN ,  YONG HONG ,  YEH VINCE S

IPC: C07C235/14 ,  A61K31/4402 ,  A61P3/10 ,  C07C317/16 ,  C07C323/41 ,  C07D207/48 ,  C07D213/64 ,  C07D233/54 ,  C07D257/04 ,  C07D261/08

Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

公开(公告)号：AT555081T

公开(公告)日：2012-05-15

申请号：AT06717418

申请日：2006-01-05

Applicant: ABBOTT LAB

Inventor： PATEL JYOTI ,  SHUAI QI ,  LINK JAMES ,  ROHDE JEFFREY ,  DINGES JURGEN ,  SORENSEN BRYAN ,  WINN MARTIN ,  YONG HONG ,  YEH VINCE

IPC: C07C235/14 ,  C07C317/16 ,  C07C323/41 ,  C07D207/48 ,  C07D213/64 ,  C07D233/54 ,  C07D257/04 ,  C07D261/08

Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

公开(公告)号：HU226888B1

公开(公告)日：2010-01-28

申请号：HU9901580

申请日：1997-02-12

Applicant: ABBOTT LAB

Inventor： BOYD STEVEN A ,  HENRY KENNETH JR ,  HUTCHINS CHARLES W ,  JAE HWAN-SOO ,  KESTER JEFFREY A ,  KING STEVEN A ,  LIU GANG ,  SORENSEN BRYAN K ,  SZCZEPANKIEWICZ BRUCE G ,  TASKER ANDREW S ,  WINN MARTIN ,  WITTENBERGER STEVEN J ,  VON GELDERN THOMAS W

IPC: A61K31/40 ,  A61K31/4025 ,  A61K31/435 ,  A61K31/4439 ,  A61P9/00 ,  A61P35/00 ,  C07D207/04 ,  C07D207/16 ,  C07D211/06 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07F9/572 ,  C07F9/59

公开(公告)号：BRPI0606256A2

公开(公告)日：2009-06-09

申请号：BRPI0606256

申请日：2006-01-05

Applicant: ABBOTT LAB

Inventor： PATEL JYOTI R ,  SHUAI QI ,  LINK JAMES T ,  ROHDE JEFFREY J ,  DINGES JURGEN ,  SORENSEN BRYAN K ,  WINN MARTIN ,  YONG HONG ,  YEH VINCE S

IPC: C07C235/14 ,  A61K31/4402 ,  A61P3/10 ,  C07C233/54 ,  C07C257/04 ,  C07C317/16 ,  C07C323/41 ,  C07D207/48 ,  C07D213/64 ,  C07D261/08

Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

公开(公告)号：EA009052B1

公开(公告)日：2007-10-26

申请号：EA200401528

申请日：2000-04-03

Applicant: ABBOTT LAB

Inventor： LINK JAMES ,  LIU GANG ,  PEI ZHONGHUA ,  VON GELDERN TON ,  WINN MARTIN ,  XIN ZHILI ,  WANG SHELDON ,  BOYD STEVEN A ,  ZHU GUI-DONG ,  FREEMAN JENNIFER C ,  GUNAWARDANA INDRANI W ,  STAEGER MICHAEL A ,  JAE HWAN-SOO ,  LYNCH JOHN K

IPC: C07D211/62 ,  C07D243/08 ,  A61K20060101 ,  A61K31/10 ,  A61K31/165 ,  A61K31/33 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/41 ,  A61K31/417 ,  A61K31/438 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/472 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61P20060101 ,  A61P29/00 ,  A61P37/06 ,  C07C20060101 ,  C07C323/60 ,  C07C323/62 ,  C07D20060101 ,  C07D205/04 ,  C07D207/09 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D207/273 ,  C07D209/08 ,  C07D209/12 ,  C07D211/20 ,  C07D211/22 ,  C07D211/32 ,  C07D211/46 ,  C07D211/60 ,  C07D211/64 ,  C07D211/66 ,  C07D211/70 ,  C07D213/40 ,  C07D213/74 ,  C07D213/81 ,  C07D215/24 ,  C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D233/61 ,  C07D239/42 ,  C07D241/04 ,  C07D241/24 ,  C07D257/04 ,  C07D279/12 ,  C07D295/18 ,  C07D295/185 ,  C07D295/20 ,  C07D295/205 ,  C07D295/22 ,  C07D295/26 ,  C07D307/24 ,  C07D307/52 ,  C07D307/68 ,  C07D317/58 ,  C07D317/66 ,  C07D319/18 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D471/20 ,  C07D487/04 ,  C07D491/113 ,  C07D521/00

Abstract: Настоящееизобретениеотноситсяк новымпроизводнымдиарилсульфидовформулы (I), вкоторыхпокрайнеймереодиниз R-Rпредставляет "цис-циннамид" (а) или "транс-циннамид" (b), адругиерадикалыопределеныв формулеизобретенияи которыемогутбытьиспользованыдлялечениявоспалительныхи иммунныхзаболеваний; кспособамполучениязаявленныхсоединенийи промежуточнымсоединениям, используемымв указанныхспособах.

公开(公告)号：BG65177B1

公开(公告)日：2007-05-31

申请号：BG10573201

申请日：2001-07-25

Applicant: ABBOTT LAB

Inventor： LINK JAMES ,  LIU GANG ,  PEI ZHONGHUA ,  VON GELDERN TOM ,  WINN MARTIN ,  XIN ZHILI ,  BOYD STEVEN ,  JAE HWAN-SOO ,  LYNCH JOHN ,  ZHU GUI-DONG ,  FREEMAN JENNIFER ,  GUNAWARDANA INDRANI ,  STAEGER MICHAEL

IPC: C07C323/62 ,  C07D295/12 ,  A61K31/10 ,  A61K31/16 ,  A61K31/164 ,  A61K31/165 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/404 ,  A61K31/407 ,  A61K31/417 ,  A61K31/438 ,  A61K31/44 ,  A61K31/443 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/4468 ,  A61K31/45 ,  A61K31/453 ,  A61K31/454 ,  A61K31/472 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/541 ,  A61P29/00 ,  A61P37/02 ,  C07C323/00 ,  C07C323/63 ,  C07D207/08 ,  C07D207/09 ,  C07D207/12 ,  C07D207/14 ,  C07D207/20 ,  C07D207/22 ,  C07D207/26 ,  C07D207/263 ,  C07D207/27 ,  C07D207/273 ,  C07D207/34 ,  C07D207/36 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D209/30 ,  C07D209/38 ,  C07D211/22 ,  C07D211/26 ,  C07D211/42 ,  C07D211/44 ,  C07D211/46 ,  C07D211/54 ,  C07D211/60 ,  C07D211/62 ,  C07D211/66 ,  C07D211/74 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D215/04 ,  C07D215/36 ,  C07D217/06 ,  C07D233/61 ,  C07D235/26 ,  C07D239/42 ,  C07D241/04 ,  C07D241/18 ,  C07D241/24 ,  C07D243/08 ,  C07D265/30 ,  C07D295/13 ,  C07D295/16 ,  C07D295/18 ,  C07D295/185 ,  C07D295/20 ,  C07D295/205 ,  C07D295/215 ,  C07D295/26 ,  C07D295/32 ,  C07D307/52 ,  C07D307/68 ,  C07D311/22 ,  C07D317/58 ,  C07D317/62 ,  C07D319/18 ,  C07D319/20 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D411/04 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/10 ,  C07D487/08 ,  C07D491/10

Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.