公开(公告)号：DE3542994A1

公开(公告)日：1987-06-11

申请号：DE3542994

申请日：1985-12-05

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  BALDINGER VERENA DR ,  GRIES JOSEF DR MED ,  LENKE DIETER PROF DR ,  RASCHACK MANFRED DR ,  RUEBSAMEN KLAUS DR

IPC: A61K31/135 ,  A61P1/04 ,  A61P9/00 ,  A61P9/12 ,  C07C223/02 ,  C07D317/58 ,  C07D319/18 ,  C07D325/00 ,  C07C95/08

公开(公告)号：AT12099T

公开(公告)日：1985-03-15

申请号：AT82102699

申请日：1982-03-31

Applicant: BASF AG

Inventor： EHRMANN OSKAR DR ,  RASCHACK MANFRED DR ,  GRIES JOSEF DR ,  KRETZSCHMAR ROLF DR ,  LEHMANN HANS DIETER DR ,  FRIEDRICH LUDWIG DR ,  WUPPERMANN DIRK DR ,  ZIMMERMANN FRANK DR ,  SEITZ WERNER DR ,  TREIBER HANS JOERG DR ,  DENGEL FERDINAND DR ,  FRANK WOLFRAM DR ,  KURBJUWEIT HANS-GEORG DR ,  MUELLER CLAUS D DR

IPC: A61K31/275 ,  A61K31/335 ,  C07D317/60 ,  C07D319/08 ,  C07C121/75 ,  C07C121/66 ,  C07C149/42

公开(公告)号：DE2960324D1

公开(公告)日：1981-08-13

申请号：DE2960324

申请日：1979-09-18

Applicant: BASF AG

Inventor： ALBRECHT HANS PETER DR ,  VON PHILIPSBORN GERDA DR ,  SIEBENEICK HANS ULRICH DR ,  RASCHACK MANFRED DR

IPC: A61K31/704 ,  A61P9/04 ,  C07J19/00 ,  C07J53/00 ,  A61K31/705

Abstract: 4,5-methano-bufadienolide-rhamnosides of the formula I I where R1 is hydrogen or alkyl or acyl of 1 to 4 carbon atoms, R2 and R3 are identical or different and each is hydrogen or alkyl or acyl of 1 to 4 carbon atoms, or both together are where R4 and R5 are identical or different and each is hydrogen or alkyl or alkoxy of 1 or 2 carbon atoms. The novel compounds may be used for counteracting cardiac insufficiency.

公开(公告)号：CZ9800641A3

公开(公告)日：1998-09-16

申请号：CZ64198

申请日：1996-08-29

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  KLING ANDREAS DR ,  KLINGE DAGMAR DR ,  REICHERS HARTMUT DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  HERGENRODER STEFAN ,  ELGER BERND ,  SCHULT SABINE DR

IPC: C07D317/02 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/35 ,  A61K31/352 ,  A61K31/357 ,  A61K31/36 ,  A61K31/435 ,  A61K31/44 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  C07C53/134 ,  C07C57/30 ,  C07C57/32 ,  C07C57/38 ,  C07C59/64 ,  C07C69/616 ,  C07C69/734 ,  C07C255/00 ,  C07D213/55 ,  C07D213/64 ,  C07D221/04 ,  C07D239/26 ,  C07D239/34 ,  C07D239/52 ,  C07D239/70 ,  C07D257/04 ,  C07D307/79 ,  C07D317/50 ,  C07D317/60 ,  C07D319/02 ,  C07D319/18

CPC classification number: C07D213/64 ,  C07C57/30 ,  C07C57/38 ,  C07C59/64 ,  C07C69/616 ,  C07C69/734 ,  C07D213/55 ,  C07D221/04 ,  C07D239/26 ,  C07D239/34 ,  C07D239/52 ,  C07D239/70 ,  C07D307/79 ,  C07D317/60 ,  C07D319/18

公开(公告)号：CZ64198A3

公开(公告)日：1998-09-16

申请号：CZ64198

申请日：1996-08-29

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  KLING ANDREAS DR ,  KLINGE DAGMAR DR ,  REICHERS HARTMUT DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  HERGENRODER STEFAN ,  ELGER BERND ,  SCHULT SABINE DR

IPC: C07D317/02 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/35 ,  A61K31/352 ,  A61K31/357 ,  A61K31/36 ,  A61K31/435 ,  A61K31/44 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  C07C53/134 ,  C07C57/30 ,  C07C57/32 ,  C07C57/38 ,  C07C59/64 ,  C07C69/616 ,  C07C69/734 ,  C07C255/00 ,  C07D213/55 ,  C07D213/64 ,  C07D221/04 ,  C07D239/26 ,  C07D239/34 ,  C07D239/52 ,  C07D239/70 ,  C07D257/04 ,  C07D307/79 ,  C07D317/50 ,  C07D317/60 ,  C07D319/02 ,  C07D319/18

Abstract: PCT No. PCT/EP96/03793 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09294 PCT Pub. Date Mar. 13, 1997Carboxylic acid derivatives of the formula I here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the meaning explained in the description.

公开(公告)号：DE59102245D1

公开(公告)日：1994-08-25

申请号：DE59102245

申请日：1991-10-04

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58 ,  C07D401/12

Abstract: Phenylpiperidylamines of the formula I I R1 is H, NO2, R4SO2NH, N=C, CF3, CF3O, F, Cl, Br, C1-C4-alkyl, R3O, CO2R3, CHO, CH=NOR3, CH3OR3 and R2 is H, F, Cl, Br, C1-C4-alkyl or R4O, where R1 and R2 are not both H, R3 is H or R4, R4 is C1-C4-alkyl or phenyl, n is 1, 2, 3 or 4 and Ar is and the physiologically tolerated salts thereof, are used as active ingredients in drugs.

公开(公告)号：ES2053455T3

公开(公告)日：1994-08-01

申请号：ES87100995

申请日：1987-01-24

Applicant: BASF AG

Inventor： UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  BALDINGER VERENA DR ,  DENGEL FERDINAND DR ,  EHRMANN OSKAR DR ,  TREIBER HANS JOERG DR ,  SEITZ WERNER DR

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61P7/02 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/43 ,  C07C255/53 ,  C07C255/58 ,  C07D317/58 ,  C07D319/08 ,  C07D319/18 ,  C07D321/12 ,  C07D325/00

公开(公告)号：DE4216942A1

公开(公告)日：1993-11-25

申请号：DE4216942

申请日：1992-05-22

Applicant: BASF AG

Inventor： HELLENDAHL BEATE DR ,  SCHLECKER RAINER DR ,  ROEHL FRANZ DR ,  ZIPPLIES MATTHIAS DR ,  RASCHACK MANFRED DR ,  HAFNER MATTHIAS DR

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P31/04 ,  C07D217/04 ,  C07D217/06

Abstract: Medicament for oral administration which contains as active substance per individual dose, besides the customary galenic auxiliaries, 10 to 1000 mg of a compound of general formula (I) or (II) in which W is a carbonyl group or a single bond, R is a hydrogen atom or a group of the general formula R CO in which R is a lower alkyl, lower alkoxy, mono lower alkylamino or di lower alkylamino group, R is an alkyl residue with 3 to 20 carbon atoms which may be branched or unbranched and contain 1 to 3 double bonds, a saturated cycle of 3 to 7 carbon atoms integrated into the chain or as substituent, or may be substituted by one or more aromatic rings or contain an oxygen or sulphur atom, as a racemate and as isolated enantiomers; or the addition salt thereof with a physiologically acceptable acid, and the active substances themselves insofar as they are novel.

公开(公告)号：AT87907T

公开(公告)日：1993-04-15

申请号：AT87100995

申请日：1987-01-24

Applicant: BASF AG

Inventor： UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  BALDINGER VERENA DR ,  DENGEL FERDINAND DR ,  EHRMANN OSKAR DR ,  TREIBER HANS JOERG DR ,  SEITZ WERNER DR

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61P7/02 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/43 ,  C07C255/53 ,  C07C255/58 ,  C07D317/58 ,  C07D319/08 ,  C07D319/18 ,  C07D321/12 ,  C07D325/00

公开(公告)号：DE3869273D1

公开(公告)日：1992-04-23

申请号：DE3869273

申请日：1988-08-06

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  RASCHACK MANFRED DR ,  GRIES JOSEF DR

IPC: A61K31/34 ,  A61K31/343 ,  A61K31/40 ,  A61K31/44 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  C07D307/86 ,  C07D405/06 ,  C07D405/12

Abstract: Benzofuram derivs.of formula (I) are new: R = R' = H or R + R' = a bond; R1 and R2 = H, 1-4C alkyl or phenyl(1-4C)alkyl; Ar = phenyl with 0.3 substits. selected from benzyloxy, F, Cl, Br, OH, 1-6C alkoxy, NH2, mono- or or di(1-4C alkyl)amino, 1-4C acylamino, NO2, CH2OH and 1-4C alkyl or two adjacent substits. are linked to form CH=CH-NH; R4 and R5 = H, 1-4C alkyl or phenyl(1-4C)alkyl, where the phenyl gp. is opt. mono- or disubstd. by F, Cl, Br, 1-4C alkoxy, NH2, mono-or di(1-4C alkyl)amino or NO2, or R4 + R5 = a 3- to 6-membered chain opt. contg. an O or N atom and opt. fused with a benzene ring opt. substd. by F, Ce, Br, 1-4C alkoxy, NH2, mono-or di(1-4C alkyl)amino or NO2; X = COCH=CH, COCH2CH2 or CH(OH)CH2CH2; n = 2 or 3; provided that when R1 = R2 = Me, then R4 = H or alkyl and R5 = opt. substd. phenylakyl or R4+R5 = a 3- to -6 membered chain (opt. contg. O or N) fused with an opt. substd. benzene ring.