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公开(公告)号：SI3551622T1
公开(公告)日：2021-02-26
申请号：SI201730537
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/00 , A61K31/00 , A61P11/00 , C07D231/00
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公开(公告)号：HRP20201603T1
公开(公告)日：2021-02-19
申请号：HRP20201603
申请日：2020-10-07
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
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公开(公告)号：RS61150B1
公开(公告)日：2020-12-31
申请号：RSP20201477
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
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公开(公告)号：MA51828A
公开(公告)日：2020-12-23
申请号：MA51828
申请日：2019-02-14
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ANDERSON COREY DON , BUSCH BRETT B , CHEN WEICHAO GEORGE , CLEMENS JEREMY J , CLEVELAND THOMAS , COON TIMOTHY RICHARD , FRIEMAN BRYAN , GHIRMAI SENAIT G , GROOTENHUIS PETER , GULEVICH ANTON V , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , KANG PING , KHATUYA HARIPADA , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE , SWIFT SARA E , TERMIN ANDREAS , UY JOHNNY , VOGEL CARL V , ZHOU JINGLAN
IPC: A61K31/437 , A61P11/00 , C07D513/22 , C07D515/22
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公开(公告)号：MA41051B1
公开(公告)日：2020-11-30
申请号：MA41051
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
Abstract: La présente invention concerne un composé de formule (i): (i) ou un sel pharmaceutiquement acceptable de celui-ci, où r1, r2, r3, w, x, y, z, n, o, p et q sont tels que définis dans la description, lequel composé est utile pour le traitement de maladies médiées par le cftr, telles que la mucoviscidose. La présente invention concerne également des compositions pharmaceutiques, une méthode de traitement et des kits correspondants.
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Patent Agency Ranking
公开(公告)号：SI3203840T1
公开(公告)日：2020-10-30
申请号：SI201531355
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A61K31/00 , A01N41/00 , C07D209/00 , C07D213/00 , C07D231/00 , C07D235/00 , C07D239/00 , C07D401/00 , C07D403/00 , C07D407/00 , C07D413/00
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公开(公告)号：SG10201913595YA
公开(公告)日：2020-02-27
申请号：SG10201913595Y
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
Abstract: Compounds of Formula I:pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：CR20190211A
公开(公告)日：2019-07-11
申请号：CR20190211
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： MCCARTNEY JASON , ANDERSON COREY , CLEVELAND THOMAS , JOSHI PRAMOD VIRUPAX , ZHOU JINGLAN , BAEK MINSON , FRIEMAN BRYAN A , BUSCH BRETT BRADLEY , SIESEL DAVID ANDREW , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , VAN GOOR FREDRICK , TERMIN ANDREAS P , PARASELLI PRASUNA , GROOTENHUIS PETER , HUGHES ROBERT M , ALCACIO TIMOTHY , HADIDA RUAH SARA SABINA , ZHANG BEILI , KRENITSKY PAUL JOHN , UY JOHNNY , KHATUYA HARIPADA; , MELILLO VITO; , MILLER MARK THOMAS , PIERRE FABRICE JEAN DENIS , ABELA ALEXANDER RUSSELL
IPC: C07D471/14 , A61K31/4439 , A61P11/12 , C07B59/00 , C07D401/14 , C07D498/14
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公开(公告)号：CA3019380A1
公开(公告)日：2017-10-05
申请号：CA3019380
申请日：2017-03-31
Applicant: VERTEX PHARMA
Inventor： BEAR BRIAN , CLEMENS JEREMY , CLEVELAND THOMAS , COON TIMOTHY RICHARD , GROOTENHUIS PETER DIEDERIK JAN , FRIEMAN BRYAN A , HADIDA RUAH SARA S , KHATUYA HARIPADA , KRENITSKY PAUL J , MILLER MARK THOMAS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/44 , A61P11/00 , C07D213/82
Abstract: The present disclosure features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, W, X, Z, n, p, and Rings A and B are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present disclosure also features pharmaceutical compositions, method of treating, and kits thereof.
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公开(公告)号：MA41051A
公开(公告)日：2017-08-16
申请号：MA41051
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , JOSHI PRAMOD VIRUPAX , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MCCARTNEY JASON , MELILLO VITO , MILLER MARK THOMAS , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
Abstract: La présente invention concerne un composé de formule (i): (i) ou un sel pharmaceutiquement acceptable de celui-ci, où r1, r2, r3, w, x, y, z, n, o, p et q sont tels que définis dans la description, lequel composé est utile pour le traitement de maladies médiées par le cftr, telles que la mucoviscidose. La présente invention concerne également des compositions pharmaceutiques, une méthode de traitement et des kits correspondants.
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