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公开(公告)号：AT517106T
公开(公告)日：2011-08-15
申请号：AT07751501
申请日：2007-02-22
Applicant: VERTEX PHARMA
Inventor： MAKINGS LEWIS , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE , NAKATANI AKIKO , TERMIN ANDREAS , SILINA ALINA
IPC: C07D471/10 , A61K31/438 , A61K31/46 , A61K31/4747 , A61P25/00 , C07D519/00
Abstract: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：CA2783314A1
公开(公告)日：2011-06-16
申请号：CA2783314
申请日：2010-12-10
Applicant: VERTEX PHARMA
Inventor： SHETH URVI , FANNING TEV T D , NUMA MEHDI , BINCH HAYLEY , HURLEY DENNIS JAMES , ZHOU JINGLAN , HADIDA RUAH SARA S , HAZLEWOOD ANNA R , SILINA ALINA , VAIRAGOUNDAR RAJENDRAN , VAN GOOR FREDRICK F , GROOTENHUIS PETER DIEDERIK JAN , BOTFIELD MARTYN C
IPC: C07D215/56 , A61K31/4709 , A61P11/00 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/08
Abstract: The present invention relates to 4-oxo-1H-quinoline-3-carboxamides as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：NZ553202A
公开(公告)日：2010-12-24
申请号：NZ55320205
申请日：2005-08-19
Applicant: VERTEX PHARMA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
IPC: A61K31/435 , A61K31/438 , A61P25/00 , A61P43/00 , C07D471/00
Abstract: Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt therof wherein the substituent G is a adamantyl, or a bicyclic or a tricyclic group of formula (III) and the remaining substituents are as defined in the specification. Also disclosed is the use of the compounds for treating muscarinic receptor mediated diseases such as CNS derived pathologies, Attention Deficit Hyperactivity Disorder (ADHD), obesity, Alzheimer's disease and dementia.
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公开(公告)号：AU2007221220A1
公开(公告)日：2007-09-07
申请号：AU2007221220
申请日：2007-02-22
Applicant: VERTEX PHARMA
Inventor： SILINA ALINA , NAKATANI AKIKO , BLANCO MIGUEL GARCIA-GUZMAN , DRUTU IOANA , MAKINGS LEWIS R , TERMIN ANDREAS P , BERGERON DANIELE M , RAFFAI GABRIEL , HURLEY DENNIS J
IPC: C07D471/10 , A61K31/438 , A61K31/46 , A61K31/4747 , A61P25/00 , C07D519/00
Abstract: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：AU2020252367B2
公开(公告)日：2025-04-17
申请号：AU2020252367
申请日：2020-04-02
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ABRAHAM SUNNY , ANDERSON COREY DON , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , CLEVELAND THOMAS , DWIGHT TIMOTHY A , FRIEMAN BRYAN A , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , MCCARTNEY JASON , MELILLO VITO , MILLER MARK THOMAS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: C07D239/69 , A61P11/00 , C07D515/08
Abstract: Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.
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Patent Agency Ranking
公开(公告)号：HUE064849T2
公开(公告)日：2024-04-28
申请号：HUE20722087
申请日：2020-04-02
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA SABINA , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , MCCARTNEY JASON , MELILLO VITO , MILLER MARK THOMAS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: A61P11/00 , C07D239/69 , C07D515/08
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公开(公告)号：LT3946595T
公开(公告)日：2023-12-27
申请号：LTUS2020026331
申请日：2020-04-02
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA SABINA , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , MCCARTNEY JASON , MELILLO VITO , MILLER MARK THOMAS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: A61P11/00 , C07D239/69 , C07D515/08
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公开(公告)号：CA2917198C
公开(公告)日：2022-06-07
申请号：CA2917198
申请日：2014-07-08
Applicant: VERTEX PHARMA
Inventor： DENINNO MICHAEL PAUL , ANDERSON COREY , CONROY ERICA LYNN , FRIEMAN BRYAN A , GROOTHENHUIS PETER DIEDERIK JAN , HADIDA-RUAH SARA SABINA , HURLEY DENNIS JAMES , PIERRE FABRICE JEAN DENIS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: C07D221/04 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/472 , A61P25/04 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D487/04 , C07D491/044 , C07D491/048 , C07D491/056
Abstract: The invention relates to fused piperidine amides of formula (I): (see formula I) or a pharmaceutically acceptable salt thereof, useful as inhibitors of ion channels for the treatment of pain. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：UY39458A
公开(公告)日：2022-05-31
申请号：UY39458
申请日：2021-10-07
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER , SARA SABINA HADIDA RUAH , CLEVELAND THOMAS , BRYAN A FRIEMAN , KHATUYA HARIPADA , ZHOU JINGLAN , ALEXANDER RUSSELL ABELA , MARK THOMAS MILLER , MCCARTNEY JASON , ABRAHAM SUNNY , COREY DON ANDERSON , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , TIMOTHY A DWIGHT , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , PIERRE FABRICE , SILINA ALINA , TIMOTHY RICHARD COON , JOE A TRAN , PARASELLI PRASUNA
IPC: A61K31/36 , A61K31/404 , A61K31/443 , A61K31/47 , A61K31/519 , A61P11/00 , C07D515/04 , C07D515/14
Abstract: Esta descripción proporciona moduladores del regulador de conductancia transmembranario de la fibrosis quística (CFTR), composiciones farmacéuticas que contienen al menos uno de tales moduladores, métodos de tratamiento de la fibrosis quística mediante el uso de tales moduladores y composiciones farmacéuticas, y procesos para producir tales moduladores
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公开(公告)号：UY39455A
公开(公告)日：2022-05-31
申请号：UY39455
申请日：2021-10-07
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER , SARA SABINA HADIDA RUAH , CLEVELAND THOMAS , BRYAN A FRIEMAN , ZHOU JINGLAN , ALEXANDER RUSSELL ABELA , MARK THOMAS MILLER , MCCARTNEY JASON , ABRAHAM SUNNY , COREY DON ANDERSON , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , TIMOTHY A DWIGHT , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , PIERRE FABRICE , SILINA ALINA
IPC: A61K31/36 , A61K31/404 , A61K31/443 , A61K31/47 , A61K31/519 , A61P11/00 , C07D513/04 , C07D515/04
Abstract: Esta descripción proporciona moduladores del regulador de conductancia transmembranario de la fibrosis quística (CFTR), composiciones farmacéuticas que contienen al menos uno de tales moduladores, métodos de tratamiento de la fibrosis quística mediante el uso de tales moduladores y composiciones farmacéuticas, y procesos para producir tales moduladores
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