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    콜치신 유도체를 유효성분으로 포함하는 암의 예방 또는 치료용 조성물
    54.
    发明公开
    콜치신 유도체를 유효성분으로 포함하는 암의 예방 또는 치료용 조성물 有权
    用于预防或治疗包含化合物衍生物的癌症的组合物

    公开(公告)号：KR1020140086355A

    公开(公告)日：2014-07-08

    申请号：KR1020120156713

    申请日：2012-12-28

    Applicant: 한국화학연구원

    Inventor： 민용기 ,  김혜주 ,  최상운 ,  서지희 ,  이규양

    IPC: C07C233/06 ,  A61K31/16 ,  A61P35/00

    Abstract: The present invention relates to a novel colchicine derivative or a pharmaceutically acceptable salt thereof and to a composition for preventing or treating cancer comprising the same as an active ingredient. The novel colchicine derivative of the present invention significantly reduces the expression of polo-like kinase (Plk-1) and stimulates the apoptosis of cancer cells while markedly suppressing the growth of the cancer cells by activating p21 and p53, thereby being capable of being usefully applied to an effective treatment composition on various cancers.

    Abstract translation: 本发明涉及一种新的秋水仙素衍生物或其药学上可接受的盐，以及涉及用于预防或治疗癌症的组合物，其包含其作为活性成分。 本发明的新型秋水仙碱衍生物显着降低了polo样激酶（Plk-1）的表达，刺激癌细胞凋亡，同时通过激活p21和p53显着抑制癌细胞的生长，从而有效地 适用于各种癌症的有效治疗组合物。

    1-［2-（4-니트로-페닐）-벤즈옥사졸-5-일］-프로판-1-온을 유효성분으로 함유하는 톡소포자충 및 콕시디움에 기인한 질환의 예방 및 치료용 조성물
    57.
    发明公开
    1-［2-（4-니트로-페닐）-벤즈옥사졸-5-일］-프로판-1-온을 유효성분으로 함유하는 톡소포자충 및 콕시디움에 기인한 질환의 예방 및 치료용 조성물 有权
    包含1- [2-（4-硝基苯基） - 苯基 - 氧杂环己烯-5-基] - 丙-1-酮（1124JH0013）的组合物，用于预防和治疗由毒素和毒素引起的疾病

    公开(公告)号：KR1020110121143A

    公开(公告)日：2011-11-07

    申请号：KR1020100040600

    申请日：2010-04-30

    Applicant: 원광대학교산학협력단 ,  한국화학연구원

    Inventor： 박현 ,  김성연 ,  김석 ,  이규양 ,  김한영 ,  서지희 ,  김낙정

    IPC: A61K31/423 ,  A61P31/00 ,  A61P43/00

    CPC classification number: A61K31/423 ,  A23K20/137

    Abstract: PURPOSE: A 1-[2-(4-nitro-phenyl)-benzooxazole-5-yl]-propane-1-one compound(1124JH0013) is provided to ensure excellent anti-coccidium effect. CONSTITUTION: A 1-[2-(4-nitro-phenyl)-benzooxazole-5-yl]-propane-1-one compound having anti-coccidium effect or pharmaceutically acceptable salt thereof is denoted by structural formula A. A veterinary composition for preventing or treating diseases caused by coccidium contains the compound of formula A or the salt as an active ingredient. A pharmaceutical composition for preventing and treating diseases caused by coccidium contains the compound as an active ingredient. An animal feed additive contains the compound of formula A as an active ingredient.

    Abstract translation: 目的：提供1- [2-（4-硝基 - 苯基） - 苯并恶唑-5-基] - 丙烷-1-酮化合物（1124JH0013），以确保优异的抗球虫效果。 构成：具有抗球虫作用的1- [2-（4-硝基 - 苯基） - 苯并恶唑-5-基] - 丙烷-1-酮化合物或其药学上可接受的盐由结构式A表示。 预防或治疗由球虫引起的疾病，含有式A化合物或其盐作为活性成分。 用于预防和治疗由球虫引起的疾病的药物组合物含有该化合物作为活性成分。 动物饲料添加剂含有式A化合物作为活性成分。

    항진균 활성을 갖는 플루오로페닐 옥사졸 유도체, 이의 제조방법 및 이의 용도
    59.
    发明公开
    항진균 활성을 갖는 플루오로페닐 옥사졸 유도체, 이의 제조방법 및 이의 용도 有权
    氟代烯氧基衍生物抑制肽合成具有抗真菌活性，其制备方法和包含其的用途

    公开(公告)号：KR1020100093943A

    公开(公告)日：2010-08-26

    申请号：KR1020090013111

    申请日：2009-02-17

    Applicant: 순천대학교 산학협력단 ,  한국화학연구원

    Inventor： 최상기 ,  이규양 ,  백형록 ,  오재현 ,  성치남 ,  임채조 ,  서지희 ,  채종학

    IPC: C07D263/58 ,  C07D263/54

    Abstract: PURPOSE: A fluorophenyl oxazole derivative with antifungal activity is provided to selectively suppress protein synthesis of pathogenic fungus and to use as various antifungal agents. CONSTITUTION: A fluorophenyl oxazole derivative is denoted by chemical formula 1. A method for preparing fluorophenyl oxazole derivative or pharmaceutically acceptable salt thereof comprises: a step of performing nitration of a compound of chemical formula 6 to obtain a compound of chemical formula 7; a step of reducing the nitro compound of chemical formula 7 to obtain hydroxyl amine compound of chemical formula 8; a step of performing acylation of the hydroxy amine compound of chemical formula 8 with a compound of chemical formula 9 to obtain an amide compound of chemical formula 10; and a step of cyclizing the amide compound of chemical formula 10 to obtain the compound of chemical formula 1.

    Abstract translation: 目的：提供具有抗真菌活性的氟苯基恶唑衍生物，以选择性抑制病原真菌的蛋白质合成并用作各种抗真菌剂。 构成：氟苯基恶唑衍生物由化学式1表示。制备氟苯基恶唑衍生物或其药学上可接受的盐的方法包括：对化学式6的化合物进行硝化以获得化学式7化合物的步骤; 降低化学式7的硝基化合物以获得化学式8的羟胺化合物的步骤; 用化学式9的化合物进行化学式8的羟基胺化合物的酰化以获得化学式10的酰胺化合物的步骤; 使化学式10的酰胺化合物环化，得到化学式1的化合物的工序。

    2-설파닐-벤즈이미다졸-4-카르복스아미드 유도체 또는 이의약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 폴리(ＡＤＰ-리보스)폴리머라제-1(ＰＡＲＰ-1)의 과활성에 의해 유발되는 질환의 예방 또는 치료용 약학적 조성물
    60.
    发明公开
    2-설파닐-벤즈이미다졸-4-카르복스아미드 유도체 또는 이의약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 폴리(ＡＤＰ-리보스)폴리머라제-1(ＰＡＲＰ-1)의 과활성에 의해 유발되는 질환의 예방 또는 치료용 약학적 조성물 有权
    2-磺基苯并咪唑-4-羧酰胺衍生物或其药学上可接受的盐，其制备方法和含有该成分的药物组合物作为活性成分用于预防和治疗由多聚（ADP-糖基）聚合酶引起的疾病引起的疾病， 1

    公开(公告)号：KR1020100022618A

    公开(公告)日：2010-03-03

    申请号：KR1020080081209

    申请日：2008-08-20

    Applicant: 한국화학연구원

    Inventor： 이규양 ,  이선경 ,  김낙정 ,  서지희 ,  임채조 ,  이병호 ,  오광석 ,  서호원 ,  유성은 ,  이경희 ,  김유선

    IPC: C07D235/28 ,  A61K31/137 ,  A61K9/20

    Abstract: PURPOSE: A 2-sulfanyl-benzimidazole-4-carboximidazole derivative is provided to repair damaged DNA and suppress poly(ADP-ribose)polymerase-1(PARP-1) which is an enzyme causing cell damage and apoptosis. CONSTITUTION: A 2-sulfanyl-benzimidazole-4-carboximidazole derivative is denoted by chemical formula 1. A 2-sulfanyl-benzimidazole-4-carboximidazole derivative is prepared by performing alkylation of a compound of chemical formula 2 and a compound of chemical formula 3. A basic catalyst is used in the preparation. The basic catalyst is carbonate including sodium carbonate, potassium carbonate, or cesium carbonate; hydroxide including potassium hydroxide or sodium hydroxide; hydride including sodium hydride; alkoxide including sodium methoxide and sodium t-butoxide; triethylamine; or pyridine. A pharmaceutical composition for preventing or treating diseases caused by over-activation contains the 2-sulfanyl-benzimidazole-4-carboximidazole derivative or its pharmaceutically acceptable salt as an active ingredient.

    Abstract translation: 目的：提供2-硫基 - 苯并咪唑-4-甲胺唑衍生物修复损伤的DNA，并抑制作为引起细胞损伤和细胞凋亡的酶的聚（ADP-核糖）聚合酶-1（PARP-1）。 构成：2-硫基 - 苯并咪唑-4-甲胺唑衍生物由化学式1表示。2-硫基 - 苯并咪唑-4-甲胺咪唑衍生物是通过化学式2的化合物和化学式3的化合物的烷基化制备的 在制备中使用碱性催化剂。 碱性催化剂是碳酸钠，碳酸钾或碳酸铯; 氢氧化物包括氢氧化钾或氢氧化钠; 氢化物包括氢化钠; 包括甲醇钠和叔丁醇钠的醇盐; 三乙胺; 或吡啶。 用于预防或治疗由过度活化引起的疾病的药物组合物含有2-硫基 - 苯并咪唑-4-甲胺唑衍生物或其药学上可接受的盐作为活性成分。

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