Patent search ap:("ABBOTT LAB") AND inv:"BOYD STEVEN A" Page 6

51.

发明专利
Cell adhesion-inhibiting antiinflammatory compounds 未知

公开(公告)号：AU4838899A

公开(公告)日：2000-12-28

申请号：AU4838899

申请日：1999-06-28

Applicant: ABBOTT LAB

Inventor： ARENDSEN DAVID L , BHATIA PRAMILA , BOYD STEVEN A , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STEWART ANDREW O , STOUT DAVID M , ZHU GUI-DONG

IPC: A61K31/415 , A61K31/425 , A61K31/44 , A61K31/50 , A61K31/505 , C07D221/00 , C07D239/00 , C07D333/00 , C07D471/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04

52.

发明专利
CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS 未知

公开(公告)号：CA2356320A1

公开(公告)日：2000-07-06

申请号：CA2356320

申请日：1999-12-29

Applicant: ABBOTT LAB

Inventor： LINK JAMES , PEI ZHONGHUA , GUNAWARDANA INDRANI W , LIU GANG , FREEMAN JENNIFER C , ZHU GUI-DONG , BOYD STEVEN A , JAE HWAN-SOO , XIN ZHILI , WINN MARTIN , LYNCH JOHN K , VON GELDERN TOM , STAEGER MICHAEL A

IPC: C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/10 , C07D295/20 , A61K31/33

Abstract: The present invention relates to novel cinnamide compounds that are useful f or treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

53.

发明专利
4-(benzo-1, 3-dioxolyl)-pyrrolidine-3-carboxylic acid derivatives as endothelin antagonists 未知

公开(公告)号：NZ331124A

公开(公告)日：2000-05-26

申请号：NZ33112497

申请日：1997-02-10

Applicant: ABBOTT LAB

Inventor： TASKER ANDREW S , BOYD STEVEN A , SORENSEN BRYAN K , WINN MARTIN , JAE HWAN-SOO , VON GELDERN THOMAS W , HENRY KENNETH J

IPC: A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/675 , A61P1/00 , A61P7/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61P25/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07F9/572

Abstract: A compound of above formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof. The compounds have use in and a method of antagonizing endothelin and therefore in the treatment of hypertension, congestive heart failure cerebral or myocardial ischemia and artherosclerosis. Specific compounds claimed are exemplified by: Trans,trans-2-(4-propoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1((2,6-diethyl)phenylaminocarbonylmethyl)-pyrrolidine-3-carboxylic acid; [2R,3R,4S]2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(N-((2,6-diethyl)phenylaminocarbonylmethyl)-pyrrolidine-3-carboxylic acid; [2R,3R,4S]2-(4-propoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(N-((2,6-diethyl)phenylaminocarbonylmethyl)-pyrrolidine-3-carboxylic acid; and [2R,3R,4S]2-(4-ethoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(N-((2,6-diethyl)phenylaminocarbonylmethyl)-pyrrolidine-3-carboxylic acid;

54.

发明专利
Benzo-1, 3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists 未知

公开(公告)号：NZ330818A

公开(公告)日：2000-05-26

申请号：NZ33081897

申请日：1997-02-12

Applicant: ABBOTT LAB

Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN SOO , TASKER ANDREW S , VON GELDERN THOMAS W , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A

IPC: A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/506 , A61K31/675 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P25/06 , A61P43/00 , C07D207/16 , C07D211/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07D471/04 , C07D491/04 , C07F9/572

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin. Endothelin has been shown to constrict arteries and veins, increase mean arterial blood pressure, decrease cardiac output, increase cardiac contractility in vitro, stimulate mitogenesis in vascular smooth muscle including guinea pig trachea, human urinary bladder strips and rat uterus in vitro, induce formation of gastric ulcers, stimulate release of atrial natriuretic factor in vitro and in vivo, increase plasma levels of vasopressin, aldosterone and catecholamines, inhibit release of renin in vitro and stimulate release of gonadotropins in vitro. The compound of formula (I) wherein, Z is -C(R18)(R19)-or -C(O)- wherein R18 and R19 are independently selected from hydrogen and lower alkyl; n is 0 or 1; R is (CH2)m-W wherein m is an integer from 0-6 and W is (a) -C(O)2-G wherein G is H or a carboxy protecting group, (b) -PO3H2, (c) -P(O)(OH)E wherein E is hydrogen, lower alkyl or arylalkyl, (d) -CN, (e) -C(O)NHR17 wherein R17 is lower alkyl, (f) alkylaminocarbonyl, (g) dialkylaminocarbonyl, (h) tetrazolyl, (i) hydroxy, (j) alkoxy, (k) sulfonamido, (l) -C(O)NHS(O)2R16 wherein R16 is loweralkyl, haloalkyl, aryl or dialkylamino, (m) -S(O)2NHC(O)R16, (n)-(u) are represented in the figures provided; R1-R25 are selected from common hydrocarbon groups.