公开(公告)号：EA018891B1

公开(公告)日：2013-11-29

申请号：EA201170601

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  FANNING LEV T D ,  HURLEY DENNIS ,  SHETH URVI ,  SILINA ALINA ,  YANG XIAOQING ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  NUMA MEHDI MICHEL DJAMEL

IPC: C07D451/02 ,  A61K31/439 ,  A61P11/00

Abstract: Изобретениеотноситсяк модуляторамрегуляторатрансмембраннойпроводимостипримуковисцидозе ("CFTR"), ихкомпозициями способамихприменения. Изобретениетакжеотноситсяк способамлечениязаболеванийприиспользованиимодуляторов CFTR.

公开(公告)号：ZA201200722B

公开(公告)日：2013-05-29

申请号：ZA201200722

申请日：2012-01-30

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER R ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: A61K20060101 ,  A61P20060101

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：MX2011004375A

公开(公告)日：2013-03-07

申请号：MX2011004375

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  FANNING LEV T D ,  HURLEY DENNIS ,  SHETH URVI ,  SILINA ALINA ,  YANG XIAOQING ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  GOOR FREDRICK VAN ,  NUMA MEHDI MICHEL DJAMEL

IPC: A61K31/439 ,  C07D451/02 ,  A61P11/00

Abstract: La presente invención se relaciona con moduladores del regulador de conductancia transmembrana de fibrosis quística ("CFTR"), las composiciones de los mismos, y los métodos con los mismos. La presente invención también se relaciona con los métodos para tratar enfermedades utilizando los moduladores del CFTR (1); o las sales farmacéuticamente aceptables de los mismos, en donde: el anillo A se selecciona de:.

公开(公告)号：AU2010282986A1

公开(公告)日：2012-02-16

申请号：AU2010282986

申请日：2010-02-18

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER R ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: A61K9/14 ,  A61K31/47 ,  A61P19/00 ,  A61P19/10 ,  A61P43/00

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis( 1, 1 -dimethylethyl)-5-hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：AU2009282419A2

公开(公告)日：2011-03-31

申请号：AU2009282419

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K47/32

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：AU2009308284A1

公开(公告)日：2010-04-29

申请号：AU2009308284

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  FANNING LEV T D ,  HURLEY DENNIS ,  SHETH URVI ,  SILINA ALINA ,  YANG XIAOQING ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  GOOR FREDRICK VAN ,  NUMA MEHDI MICHEL DJAMEL

IPC: C07D451/02 ,  A61K31/439 ,  A61P11/00 ,  C07D453/04 ,  C12Q1/02

Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.

公开(公告)号：AU2009308241A1

公开(公告)日：2010-04-29

申请号：AU2009308241

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： ZHANG BEILI ,  KRAWIEC MARIUSZ ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  GOOR FREDRICK VAN

IPC: C07D215/56 ,  A61K31/4704 ,  A61P1/00 ,  A61P11/00

公开(公告)号：AU2009308232A1

公开(公告)日：2010-04-29

申请号：AU2009308232

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  FANNING LEV T D ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  GOOR FREDRICK VAN ,  NUMA MEHDI MICHEL DJAMEL

IPC: C07D487/08 ,  A61K31/4709 ,  A61P11/00 ,  A61P43/00

Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.

公开(公告)号：AU2002359332A1

公开(公告)日：2003-05-12

申请号：AU2002359332

申请日：2002-10-30

Applicant: VERTEX PHARMA

Inventor： BOTFIELD MARTYN ,  PENG JEFFREY W

IPC: G01N24/12 ,  C12P21/04 ,  G01N33/566 ,  G01R33/465 ,  G06F19/00 ,  G06F19/16 ,  G06F19/18 ,  G06F17/00

Abstract: The present invention relates to methods of identifying compounds that can bind to a membrane-bound receptor.

公开(公告)号：CA2450074A1

公开(公告)日：2002-12-27

申请号：CA2450074

申请日：2002-06-13

Applicant: VERTEX PHARMA

Inventor： BOTFIELD MARTYN ,  TOMLINSON RONALD ,  OTTOW ECKARD ,  LAUFFER DAVID

IPC: C07D295/18 ,  A61K31/445 ,  A61K31/495 ,  A61K45/00 ,  A61P3/10 ,  A61P9/10 ,  A61P19/00 ,  A61P19/02 ,  A61P21/00 ,  A61P21/04 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07B61/00 ,  C07D211/16 ,  C07D295/185 ,  C07D241/04 ,  A61K31/395 ,  A61K31/496

Abstract: The present invention relates to acyclic piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.