-
公开(公告)号：ECSP21085481A
公开(公告)日：2022-01-31
申请号：ECDI202185481
申请日：2021-11-25
Applicant: VERTEX PHARMA
Inventor： GIACOMETTI ROBERT DANIEL , MEDEK ALES , GARCIA BARRANTES PEDRO MANUEL , HOOD SARAH CAROL , LOOKER ADAM , NUHANT PHILIPPE MARCEL , SAWANT RUPA , CLARK MICHAEL PHILIP , SPOSATO MARISA , KESAVAN SARATHY , STAVROPOULOS KATHY , SHRESTHA MUNA , TANG QING , HALL AMY BETH , SHI YI , BOUCHER DIANE , RODAY SETU , LAI MEI-HSIU , FANNING LEV TYLER DEWEY , GREY JR RONALD LEE , ZAKY MARIAM , TAPLEY TIMOTHY LEWIS , RONKIN STEVEN M , MAXWELL BRAD , JONES PETER , JOHNSON JR MAC ARTHUR , HURLEY DENNIS JAMES , THOMSON STEPHEN , BLIGH CAVAN MCKEON , BOYD MICHAEL JOHN , MAXWELL JOHN PATRICK , BANDARAGE UPUL KEERTHI , GAGNON KEVIN JAMES , FLEMING GABRIELLE SIMONE , LIU SIYING , BRODNEY MICHAEL AARON , XU JINWANG , ROEPER STEFANIE , GUIDO SAMANTHA , DAMAGNEZ VERONIQUE , OVERHOFF KIRK ALAN , SWETT REBECCA JANE , FIMOGNARI ROBERT FRANCIS , GIROUX SIMON
IPC: A61P11/00 , A61K31/4162 , A61K31/429 , A61P1/16 , C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: La descripción proporciona compuestos útiles para tratar la deficiencia de alfa-1 antitripsina (AATD), de acuerdo con la fórmula (I), tautómeros de estos, sales farmacéuticamente aceptables de los compuestos, sales farmacéuticamente aceptables de los tautómeros, derivados deuterados de los compuestos, derivados deuterados de los tautómeros y derivados deuterados de las sales, formas sólidas de esos compuestos y procesos para preparar esos compuestos. (LA FORMULA SE OBSERVA EN LA MEMORIA TECNICA)
-
公开(公告)号：SG11202112414UA
公开(公告)日：2021-12-30
申请号：SG11202112414U
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM , COTTRELL KEVIN MICHAEL
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I):tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
-
公开(公告)号：MX2021013993A
公开(公告)日：2021-12-10
申请号：MX2021013993
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM , ROEPER STEFANIE , FANNING LEV TYLER DEWEY , HURLEY DENNIS JAMES , JONES PETER , SHI YI , COTTRELL KEVIN MICHAEL , MAXWELL JOHN PATRICK , RONKIN STEVEN M , GIROUX SIMON , STAVROPOULOS KATHY , BRODNEY MICHAEL AARON , MEDEK ALES , SHRESTHA MUNA , ZAKY MARIAM , NUHANT PHILIPPE MARCEL , BLIGH CAVAN MCKEON , GAGNON KEVIN JAMES , HOOD SARAH CAROL , RODAY SETU , SAWANT RUPA , TANG QING , BANDARAGE UPUL KEERTHI , DAMAGNEZ VERONIQUE , GREY JR RONALD LEE , HALL AMY BETH , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , XU JINWANG , BOUCHER DIANE , BOYD MICHAEL JOHN , CLARK MICHAEL PHILIP , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GUIDO SAMANTHA , JOHNSON JR MAC ARTHUR , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , MAXWELL BRAD , OVERHOFF KIRK ALAN , SPOSATO MARISA , THOMSON STEPHEN , GARCIA BARRANTES PEDRO , GIACOMETTI ROBERT
IPC: A61K31/429 , A61K31/4162 , A61P1/16 , A61P11/00 , C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: La descripción proporciona compuestos útiles para tratar la deficiencia de alfa-1 antitripsina (AATD), de acuerdo con la fórmula (I), tautómeros de estos, sales farmacéuticamente aceptables de los compuestos, sales farmacéuticamente aceptables de los tautómeros, derivados deuterados de los compuestos, derivados deuterados de los tautómeros y derivados deuterados de las sales, formas sólidas de esos compuestos y procesos para preparar esos compuestos. (ver Fórmula).
-
公开(公告)号：SI3551622T1
公开(公告)日：2021-02-26
申请号：SI201730537
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/00 , A61K31/00 , A61P11/00 , C07D231/00
-
公开(公告)号：RS61150B1
公开(公告)日：2020-12-31
申请号：RSP20201477
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
-
Patent Agency Ranking
公开(公告)号：UY38696A
公开(公告)日：2020-11-30
申请号：UY38696
申请日：2020-05-13
Applicant: VERTEX PHARMA
Inventor： JONES PETER , NUHANT PHILIPPE MARCEL , BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , GAGNON KEVIN JAMES , BOYD MICHAEL JOHN , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR , KESAVAN SARATHY , LOOKER ADAM , MAXWELL JOHN PATRICK , MEDEK ALES , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , XU JINWANG , BOUCHER DIANE , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GUIDO SAMANTHA , LAI MEI-HSIU , LIU SIYING , MAXWELL BRAD , OVERHOFF KIRK ALAN , RONKIN STEVEN M , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , THOMSON STEPHEN , ZAKY MARIAM , BRODNEY MICHAEL AARON
IPC: A61P1/16 , A61K31/4162 , A61P11/00 , C07D487/14 , C07D498/18
Abstract: La descripción proporciona compuestos útiles para tratar la deficiencia de alfa-1 antitripsina (AATD), de acuerdo con la fórmula (I), tautómeros de estos, sales farmacéuticamente aceptables de los compuestos, sales farmacéuticamente aceptables de los tautómeros, derivados deuterados de los compuestos, derivados deuterados de los tautómeros y derivados deuterados de las sales, formas sólidas de esos compuestos y procesos para preparar esos compuestos.
-
公开(公告)号：AU2020257041A1
公开(公告)日：2020-11-12
申请号：AU2020257041
申请日：2020-10-20
Applicant: BIOMED VALLEY DISCOVERIES INC , VERTEX PHARMA
Inventor： DECRESCENZO GARY , WELSCH DEAN , VLAHOVA PETINKA I , BOERRIGTER STEPHAN X M , ARONOV ALEXANDER , KESHAVARZ-SHOKRI ALI , SCANGAS ALEXANDER N , STAVROPOULOS KATHY , LITTLER BENJAMIN , KADIYALA IRINA NIKOLAEVNA , ALARGOVA ROSSITZA GUEORGUIEVA
IPC: C07D401/04
Abstract: : The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.
-
公开(公告)号：LT3424920T
公开(公告)日：2020-08-10
申请号：LT18188034
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , O`NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
-
公开(公告)号：HUE041877T2
公开(公告)日：2019-06-28
申请号：HUE14799578
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , O'NEIL SIMON , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: A61P35/00
-
公开(公告)号：ES2705342T3
公开(公告)日：2019-03-22
申请号：ES14799578
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , O'NEIL SIMON , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
Abstract: Un co-cristal que comprende un compuesto de la fórmula:**Fórmula** un formador de co-cristal, en la que el formador de co-cristal es ácido adípico, en la que cada uno de R1 y R2 es independientemente hidrógeno o deuterio.
-
-
-
-
-
-
-
-
-
Search Results
87
records
(took 0.022 seconds)
