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公开(公告)号：ZA9806828B
公开(公告)日：1999-01-29
申请号：ZA9806828
申请日：1998-07-30
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE R , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C , A61K , C07D
CPC classification number: C07D207/404 , C07C311/05 , C07C311/18 , C07C317/28 , C07C323/47 , C07C323/62 , C07D207/408 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
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公开(公告)号：ZA9820B
公开(公告)日：1998-07-02
申请号：ZA9820
申请日：1998-01-02
Applicant: ABBOTT LAB
Inventor： DAVIDSEN STEVEN K , SHEPPARD GEORGE S , HOLMS JAMES H , FLORJANCIC ALAN S , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , XU LIANHONG , GUO YAN , SUMMERS JAMES B
IPC: A61K31/395 , A61K31/40 , A61K31/404 , A61K31/4188 , A61K31/427 , A61K31/4427 , A61K31/4523 , A61K31/553 , A61K38/00 , A61K38/55 , A61P1/02 , A61P7/00 , A61P11/06 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D225/06 , C07D245/02 , C07D245/06 , C07D267/00 , C07D273/01 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D487/08 , C07K5/078 , C07D , A61K
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公开(公告)号：PT100443A
公开(公告)日：1993-08-31
申请号：PT10044392
申请日：1992-04-30
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , GUINN DENISE E , STEINMAN DOUGLAS H , DAVIDSEN STEVEN K , MARTIN MICHAEL B , PHILLIPS JAMES G
IPC: C07D401/04 , C07D409/04 , C07D417/04 , C07D401/00 , A61K31/435
Abstract: Benzoylphenyl derivatives of 2-(3-pyridinyl)-3-alkyl-4-thiazolidinecarboxamide, 2-(3-pyridinyl)-thiazolid-4-ylacetamide, 2-(3-pyridinyl)-4-dithiolanecarboxamide or 2-(3-pyridinyl)dithiolan-4-yl]urea-group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：IE920801A1
公开(公告)日：1992-11-04
申请号：IE920801
申请日：1992-03-12
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , STEINMAN DOUGLAS H , MARTIN MICHAEL B , DAVIDSEN STEVEN K , PHILLIPS JAMES G , GUINN DENISE E
IPC: C07D401/04 , C07D409/04 , C07D417/04 , C07D401/00 , C07D409/00 , C07D417/00
Abstract: Benzoylphenyl derivatives of 2-(3-pyridinyl)-3-alkyl-4-thiazolidinecarboxamide, 2-(3-pyridinyl)-thiazolid-4-ylacetamide, 2-(3-pyridinyl)-4-dithiolanecarboxamide or 2-(3-pyridinyl)dithiolan-4-yl]urea-group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：IE920365A1
公开(公告)日：1992-08-26
申请号：IE920365
申请日：1992-02-04
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , SHEPPARD GEORGE S , PHILLIPS JAMES G , PIREH DAISY , STEINMAN DOUGLAS H , MAY PAUL D , GUINN DENISE E , HEYMAN H ROBIN , JR GEORGE M CARRERA , DAVIDSEN STEVEN K
IPC: A61K31/44 , A61K31/4427 , A61K31/4433 , A61P7/02 , A61P11/00 , A61P29/00 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14 , C07D409/00 , C07D417/00
Abstract: Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.
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Patent Agency Ranking
公开(公告)号：CA2100682A1
公开(公告)日：1992-08-21
申请号：CA2100682
申请日：1992-02-14
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , SHEPPARD GEORGE S , PHILLIPS JAMES G , PIREH DAISY , STEINMAN DOUGLAS H , MAY PAUL D , GUINN DENISE E , HEYMAN H ROBIN , CARRERA GEORGE M JR , DAVIDSEN STEVEN K
IPC: A61K31/44 , A61K31/4427 , A61K31/4433 , A61P7/02 , A61P11/00 , A61P29/00 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14 , C07D413/14
Abstract: 2100682 9214732 PCTABS00015 Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：SI1147101T1
公开(公告)日：2003-06-30
申请号：SI200030041
申请日：2000-01-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , HEYMAN HOWARD R , HOLMES JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H
IPC: A61K31/335 , A61P35/04 , C07D207/09 , C07D207/48 , C07D263/04 , C07D307/14 , C07D317/28
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公开(公告)号：DK1147101T3
公开(公告)日：2003-03-10
申请号：DK00905758
申请日：2000-01-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , HEYMAN HOWARD R , HOLMES JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H
IPC: A61K31/341 , A61K31/357 , A61K31/40 , A61K31/421 , A61P1/02 , A61P1/04 , A61P17/02 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D207/09 , C07D207/14 , C07D207/48 , C07D263/04 , C07D307/14 , C07D317/28 , A61K31/335
Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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69.发明专利
公开(公告)号：NZ512372A
公开(公告)日：2003-01-31
申请号：NZ51237200
申请日：2000-01-27
Applicant: ABBOTT LAB
Inventor： HOLMES JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , HEYMAN HOWARD R
IPC: A61K31/341 , A61K31/357 , A61K31/40 , A61K31/421 , A61P1/02 , A61P1/04 , A61P17/02 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D207/09 , C07D207/14 , C07D207/48 , C07D263/04 , C07D307/14 , C07D317/28
Abstract: Compounds having formula (I) are matric metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting pharmaceutical compositions and uses of the compounds of formula (I) in inhibiting matrix metalloproteinase in a mammal. In formula (I): W1 is -O-, -CH20- or -CH2- wherein each group is drawn with its left-hand end being the end which attaches to the carbon containing R1 and R2, and its right-hand end being the end which attaches to the carbon containing R3 and R4. X is -O- or -N (R7)-, wherein R7 is hydrogen, alkyl, -SO2-alkyl, or alkanoyl. R1 and R2 are independently selected hydrogen, alkyl or hydroxyalkyl. R3 and R4 are independently selected hydrogen or alkyl or R3 and R4 taken together are oxo, or R3 and R4, taken together with the carbon atom to which they are attached, form a cycloalkyl ring. R5 and R6 are independently selected from hydrogen, alkyl, perfluoroalkyl, halo, haloalkyl, alkoxy, hydroxy, hydroxyalkyl, alkoxyalkyl or nitro. Y1 is a covalent bond, -O-, alkylene of two to four carbon atoms, piperidineneyl, alkenylene of two carbon atoms, alkynylene of two carbon atoms, SO2- or -C(O)-. Ar is phenyl, pyridyl, pyrazinyl, pyridazinyl, furyl, thienyl, isoxazolyl, oxazolyl, thiazolyl or isothiazolyl, which can be optionally substituted with one, two, or three substituents.
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公开(公告)号：PL349771A1
公开(公告)日：2002-09-09
申请号：PL34977100
申请日：2000-01-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , HEYMAN HOWARD R , HOLMES JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H
IPC: A61K31/341 , A61K31/357 , A61K31/40 , A61K31/421 , A61P1/02 , A61P1/04 , A61P17/02 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D207/09 , C07D207/14 , C07D207/48 , C07D263/04 , C07D307/14 , C07D317/28 , A61K31/335
Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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